PHYSICAL AND CHEMICAL CHARACTERISTICS OF AQUEOUS COLLOIDAL INFUSIONS OF MEDICINAL PLANTS CONTAINING HUMIC ACIDS

GLEB V. PETROV; IVAN A. GAIDASHEV; ANTON V. SYROESHKIN

doi:10.22159/ijap.2024v16i1.49339

Authors

GLEB V. PETROV Department of Pharmaceutical and Toxicological Chemistry, Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow-117198, Russian Federation https://orcid.org/0009-0004-1123-7393
IVAN A. GAIDASHEV Department of Pharmaceutical and Toxicological Chemistry, Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow-117198, Russian Federation https://orcid.org/0009-0009-2197-8861
ANTON V. SYROESHKIN Department of Pharmaceutical and Toxicological Chemistry, Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow-117198, Russian Federation https://orcid.org/0000-0003-3279-7520

DOI:

https://doi.org/10.22159/ijap.2024v16i1.49339

Keywords:

Humic acids, Supramolecular complexes, Thermal radio emission, SARS-CoV-2, DLS, Dynamic laser scattering

Abstract

Objective: Study of physical and chemical activity of biologically active substances containing humic complexes (HCs). Comparison of various preparations available on the market. Development of a modern express method of quality control.

Methods: Preparations containing HCs manufactured by Biotechnology System, BIODORON, Faberlic, etc. Built-in flux density sensor TES-92 (TES Electrical Electronic Corp., Taipei, Taiwan), which was used to determine the flux density of radio thermal emission in the gigahertz range. Zetasizer Nano ZSP (Malvern Panalytical, Worcestershire, UK) was used to determine the size of nanoparticles in preparations containing the HCs and MP with humic acids (HAs).

Results: In the course of experiments for studying the intrinsic radiothermal emission of HAs preparations, differences were found between HAs from different manufacturers; for example, HAs produced by a biotechnology system with a flux density of 35±5 µW/m² at 37 °C differs several times from similar preparations produced by other companies. When diluting HAs from Biotechnology System 10, 100 and 1000 times, the emissivity of the preparations is preserved. Also, with the expiration of the 2 y shelf life of the preparation, as stated by the manufacturer, a sharp drop in emissivity of 20 times is observed.

Conclusion: The radiothermal activity of HAs preparations revealed during the experiments allows the developing a method that can be utilized to control the quality of manufactured products, as well as control the expiration dates of preparations without opening the primary package.

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