MECHANISTIC INSIGHT INTO MEDICINAL PROPERTIES OF INDONESIAN DIVERSE MANGROVE SPECIES: A REVIEW
DOI:
https://doi.org/10.22159/ijap.2024v16s5.52488Keywords:
Mangrove ecosystems, Pharmacological, Diversity, Mangrove speciesAbstract
Mangrove ecosystems in Indonesia harbor a rich diversity of plant species, some of which have been traditionally recognized for their medicinal properties. This study aims to provide mechanistic insights into the medicinal potential of various mangrove species found in Indonesian coastal regions. Through a comprehensive analysis of pharmacological activities and underlying mechanisms, our research seeks to elucidate the therapeutic properties of these diverse mangrove plants. The key terms "Mangrove", "Pharmacological", and "Indonesia" used for searching in three online databases: Science Direct, PubMed, and Google Scholar. The investigation into the pharmacological properties of mangrove species revealed versatile mechanisms of action. Notably, a convergence is observed in their antioxidant mechanisms, as exemplified by Aegiceras corniculatum, Avicennia marina, and Rhizophora mucronata, showcasing robust effects in DPPH, ABTS, and FRAP assays. Additionally, the study highlights significant findings in the realm of anti-inflammatory activities. Mangrove species like Aegialitis rotundifolia, Ceriops decandra, and Rhizophora apiculata demonstrate notable anti-inflammatory effects by inhibiting enzymes like LOX and responding positively to carrageenan induction. A commonality is unveiled in antibacterial effects, with species like Avicennia marina, Ceriops tagal, and Excoecaria agallocha exhibiting potent antibacterial properties in agar diffusion assays. These findings underscore the potential of mangrove species in combating microbial infections through distinct antibacterial mechanisms. Furthermore, understanding the mechanisms behind the medicinal properties of Indonesian mangrove species is crucial for both conservation efforts and the development of novel pharmaceuticals.
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References
Kathiresan K, Bingham BL. Biology of mangroves and mangrove ecosystems. Adv Mar Biol. 2001;40:81-251. doi: 10.1016/S0065-2881(01)40003-4.
Awuku Sowah EM, Graham NA, Watson NM. Investigating mangrove human health relationships: a review of recently reported physiological benefits. Dialogues Health. 2022;1:100059. doi: 10.1016/j.dialog.2022.100059, PMID 38515922.
Dahibhate NL, Saddhe AA, Kumar K. Mangrove plants as a source of bioactive compounds: a review. Nat Prod J. 2019;9(2):86-97. doi: 10.2174/2210315508666180910125328.
Mahmud I, Islam MK, Saha S, Barman AK, Rahman MM, Anisuzzman M. Pharmacological and ethnomedicinal overview of heritiera fomes: future prospects. Int Sch Res Notices. 2014;2014:938543. doi: 10.1155/2014/938543, PMID 27382611.
Spalding M. World atlas of mangroves. Routledge; 2010.
Arbiastutie Y, Diba F, Masriani M. Short communication: ethnobotanical and ecological studies of medicinal plants in a mangrove forest in Mempawah District west Kalimantan Indonesia. Biodiversitas. 2021;22(6). doi: 10.13057/biodiv/d220619.
Zhang W, Zeng Y, Jiao M, YE C, LI Y, Liu C. Integration of high throughput omics technologies in medicinal plant research: the new era of natural drug discovery. Front Plant Sci. 2023;14:1073848. doi: 10.3389/fpls.2023.1073848, PMID 36743502.
Janmanchi H, Raju A, Degani MS, Ray MK, Rajan MG. Antituberculosis antibacterial and antioxidant activities of aegiceras corniculatum a mangrove plant and effect of various extraction processes on its phytoconstituents and bioactivity. S Afr J Bot. 2017;113:421-7. doi: 10.1016/j.sajb.2017.09.019.
Biswas R, Rahman SM, Didarul Islam KM, Billah MM, Aunjum A, Nurunnabi TR. Antioxidant anti-inflammatory and anticoagulation properties of Aegiceras corniculatum and acanthus ilicifolius. Pharm Biomed Res. 2019;5(3):35-44. doi: 10.18502/pbr.v5i3.2117.
Santos MJ. Biological research marks its 50th y by joining bio med central. Biol Res. 2014 Mar 26;47(1):1. doi: 10.1186/0717-6287-47-1, PMID 25026971.
Reddy A, Grace JR. Anticancer activity of methanolic extracts of selected mangrove plants. Int J Pharm Sci Res. 2016;7(9):3852. doi: 10.13040/IJPSR.0975-8232.7(9).3852-56.
Hasan I, Hussain MS, Millat MS, Sen N, Rahman MA, Rahman MA. Ascertainment of pharmacological activities of Allamanda neriifolia hook and aegialitis rotundifolia roxb used in Bangladesh: an In vitro study. J Tradit Complement Med. 2018;8(1):107-12. doi: 10.1016/j.jtcme.2017.03.005, PMID 29321997.
Hossain ML. Medicinal activity of Avicennia officinalis: evaluation of phytochemical and pharmacological properties. Saudi J Med Pharm Sci. 2016;2:250-5.
Eswaraiah G, Peele KA, Krupanidhi S, Kumar RB, Venkateswarulu TC. identification of bioactive compounds in leaf extract of avicennia alba by GC-MS analysis and evaluation of its In vitro anticancer potential against MCF7 and hela cell lines. J King Saud Univ Sci. 2020;32(1):740-4. doi: 10.1016/j.jksus.2018.12.010.
Rahman M, Biswas S, Bala V, Shill A, Bose U. Antidiarrhoeal and antinociceptive activities of leafs avicennia alba. Pharmacologyonline. 2011;1:492-500.
Karami L, Majd A, Mehrabian S, Nabiuni M, Salehi M. Irian s: antimutagenic and anticancer effects of Avicennia marina leaf extract on salmonella typhimurium TA100 bacterium and human promyelocytic leukaemia HL-60 cells. Sci Asia. 2012;38(3):349-55.
Das SK, Dash S, Thatoi H, Patra JK. In vitro α-amylase and α-glucosidase inhibition antioxidant anti-inflammatory activity and GC-MS profiling of Avicennia alba blume. Comb Chem High Throughput Screen. 2020;23(9):945-54. doi: 10.2174/1386207323666200428081748, PMID 32342807.
Illian D, Basyuni M, Wati R, Zaitun Hasibuan P. Polyisoprenoids from avicennia marina and Avicennia lanata inhibit WiDr cells proliferation. Phcog Mag. 2018;14(58):513-8. doi: 10.4103/pm.pm_201_18.
Sharief M, Srinivasulu A, Chittibabu B, Umamaheswararao V. Identifcation of bioactive principles of Avicennia officinalis fruit extract in methanol and screening for antibacterial activity. Int J Pharm Sci Drug Res. 2015;7(1):73-7.
Shafie M, Forghani A, Moshtaghiyan J. Anti-inflammatory effects of hydro-alcoholic extracts of mangrove (Avicennia marina) and vitamin C on arthritic rats. Boll Environ Pharmacol Life Sci. 2013;2:32-7.
Beula JM, Gnanadesigan M, Rajkumar PB, Ravikumar S, Anand M. Antiviral antioxidant and toxicological evaluation of mangrove plant from South East Coast of India. Asian Pac J Trop Biomed. 2012;2(1):S352-7. doi: 10.1016/S2221-1691(12)60187-7.
Thirunavukkarasu P, Ramanathan T, Ramkumar L, Shanmugapriya R, Renugadevi G. The antioxidant and free radical scavenging effect of Avicennia officinalis. J Med Plants Res. 2011;5(19):4754-8.
Bakshi M, Chaudhuri P. Antimicrobial potential of leaf extracts of ten mangrove species from Indian Sundarban. Int J Pharm Biol Sci. 2014;5(1):294-304.
Sura S, Anbu J, Sultan M, Uma B. Antiulcer effect of ethanolic leaf extract of Avicennia officinalis. Pharmacologyonline. 2011;3:12-9.
Hossain MH, Howlader MS, Dey SK, Hira A, Ahmed A. Evaluation of diuretic and neuropharmacological properties of the methanolic extract of Avicennia officinalis l leaves from Bangladesh. Int J Pharm Phytopharmacol Res. 2012;2:2-6.
Das SK, Samantaray D, Sahoo SK, Patra JK, Samanta L, Thatoi H. Bioactivity-guided isolation and structural characterization of the antidiabetic and antioxidant compound from bark extract of Avicennia officinalis l. S Afr J Bot. 2019;125:109-15. doi: 10.1016/j.sajb.2019.07.011.
Gawali P, Jadhav B. Antioxidant activity and antioxidant phytochemical analysis of mangrove species Sonneratia alba and Bruguiera cylindrica. Asian J Microbiol Biotechnol Environ Sci. 2011;13(2):257-61.
Pitchaipillai R, Ponniah T. In vitro antidiabetic activity of ethanolic leaf extract of Bruguiera cylindrica l glucose uptake by yeast cells method. Int Biol Biomed J. 2016;2(4):171-5.
Audah K, Amsyir J, Almasyhur F, Hapsari A, Sutanto H. Development of extract library from Indonesian biodiversity: exploration of antibacterial activity of mangrove Bruguiera cylindrica leaf extracts. IOP Conf S Earth Environ Sci. 2018;130(1):012025. doi: 10.1088/1755-1315/130/1/012025.
Karimulla S, Kumar BP. Antidiabetic and antihyperlipidemic activity of bark of Bruguiera gymnorrhiza on streptozotocin-induced diabetic rats. Asian J Pharm Sci Technol. 2011;1(1):4-7. doi: 10.13140/RG.2.2.10470.04163.
Seepana R, Perumal K, Kada NM, Chatragadda R, Raju M, Annamalai V. Evaluation of antimicrobial properties from the mangrove rhizophora apiculata and Bruguiera gymnorrhiza of burmanallah coast South Andaman India. J Coast Life Med. 2016;4(6):475-8. doi: 10.12980/jclm.4.2016J6-52.
Barik R, Sarkar R, Biswas P, Bera R, Sharma S, Nath S. 5,7-dihydroxy-2-(3-hydroxy-4, 5-dimethoxy-phenyl)-chromen-4-one-a flavone from Bruguiera gymnorrhiza displaying anti-inflammatory properties. Indian J Pharmacol. 2016;48(3):304-11. doi: 10.4103/0253-7613.182890, PMID 27298502.
Karim MA, Islam MA, Islam MM, Rahman MS, Sultana S, Biswas S. Evaluation of antioxidant anti-hemolytic cytotoxic effects and antibacterial activity of selected mangrove plants (Bruguiera gymnorrhiza and Heritiera littoralis) in Bangladesh. Clin Phytosci. 2020;6(1):1-12.
Sur TK, Hazra A, Hazra AK, Bhattacharyya D. Antioxidant and hepatoprotective properties of Indian sunderban mangrove Bruguiera gymnorrhiza l leave. J Basic Clin Pharm. 2016;7(3):75-9. doi: 10.4103/0976-0105.183262, PMID 27330259.
Bunyapraphatsara N, Jutiviboonsuk A, Sornlek P, Therathanathorn W, Aksornkaew S, Fong HH. Pharmacological studies of plants in the mangrove forest. Thai J Phytopharmacy. 2003:10(2):2.
Abeysinghe PD. Antibacterial activity of some medicinal mangroves against antibiotic-resistant pathogenic bacteria. Indian J Pharm Sci. 2010;72(2):167-72. doi: 10.4103/0250-474X.65019, PMID 20838519.
Hossain H, Moniruzzaman S, Nimmi I, Kawsar H, Hossain A, Islam A. Anti-inflammatory and antioxidant activities of the ethanolic extract of Ceriops decandra (Griff.) ding hou bark. Orient Pharm Exp Med. 2011;11(4):215-20. doi: 10.1007/s13596-011-0037-z.
Krishnamoorthy M, Sasikumar JM, Shamna R, Pandiarajan C, Sofia P, Nagarajan B. Antioxidant activities of bark extract from mangroves Bruguiera cylindrica (l.) Blume and Ceriops decandra Perr. Indian J Pharmacol. 2011;43(5):557-62. doi: 10.4103/0253-7613.84972, PMID 22022000.
Saravanan D, Radhakrishnan M. Antimicrobial activity of mangrove leaves against drug-resistant pathogens. Int J PharmTech Res. 2016;9(1):141-6.
Zhou HC, Tam NF, Lin YM, Ding ZH, Chai WM, Wei SD. Relationships between degree of polymerization and antioxidant activities: a study on proanthocyanidins from the leaves of a medicinal mangrove plant Ceriops tagal. Plos One. 2014;9(10):e107606. doi: 10.1371/journal.pone.0107606, PMID 25313980.
Sachithanandam V, Parthiban A, Lalitha P, Muthukumaran J, Jain M, Elumalai D. Biological evaluation of gallic acid and quercetin derived from Ceriops tagal: insights from extensive In vitro and in silico studies. J Biomol Struct Dyn. 2022;40(4):1490-502. doi: 10.1080/07391102.2020.1828173, PMID 32996435.
Arivuselvan N, Durai Silambarasan T, Govindan, K Kathiresan. antibacterial activity of mangrove leaf and bark extracts against human pathogens. Adv Biol Res. 2011 Jan;5(5):251-4.
Biswas B, Golder M, Abid MA, Mazumder K, Sadhu SK. Terpenoids-enriched ethanol extracts of aerial roots of Ceriops decandra (Griff.) and Ceriops tagal (Perr.) promote diuresis in mice. Heliyon. 2021;7(7):e07580. doi: 10.1016/j.heliyon.2021.e07580, PMID 34337186.
Plant LM. In vitro antioxidant analysis and the DNA damage protective activity of leaf extract of the Excoecaria agallocha. Int J Agric Chem. 2012;1(4).
Babuselvam M, Ravikumar S, Farook KM, Abideen S, Mohamed MP, Uthiraselvam M. Evaluation of anti-inflammatory and analgesic effects on the extracts of different parts of Excoecaria agallocha l. J App Pharm Sci. 2012;2(9):108-12. doi: 10.7324/JAPS.2012.2921.
Mondal S, Ghosh D, Ramakrishna K. A complete profile on blind your eye mangrove Excoecaria agallocha l (Euphorbiaceae): ethnobotany phytochemistry and pharmacological aspects. Pharmacogn Rev. 2016;10(20):123-38. doi: 10.4103/0973-7847.194049, PMID 28082796.
Patil R, Manohar SM, Upadhye MV, Katchi V, Rao AJ, Mule A. Anti reverse transcriptase and anticancer activity of stem ethanol extracts of Excoecaria agallocha (Euphorbiaceae). Ceylon J Sci (Biol Sci). 2011;40(2):147-55. doi: 10.4038/cjsbs.v40i2.3931.
Christopher R, Nyandoro SS, Chacha M, de Koning CB. A new cinnamoylglycoflavonoid antimycobacterial and antioxidant constituents from Heritiera littoralis leaf extracts. Nat Prod Res. 2014;28(6):351-8. doi: 10.1080/14786419.2013.863202, PMID 24443810.
Lin G, LI M, XU N, WU X, Liu J, WU Y. Anti-inflammatory effects of Heritiera littoralis fruits on dextran sulfate sodium (DSS-) induced ulcerative colitis in mice by regulating gut microbiota and suppressing NF-κB pathway. BioMed Res Int. 2020;2020:8893621. doi: 10.1155/2020/8893621, PMID 33354574.
Dat LD, Thao NP, Tai BH, Luyen BT, Yang SY, Kim S. Anti-inflammatory triterpenes and glyceryl glycosides from Kandelia candel (L.) druce. Nat Prod Sci. 2015;21(3):150-4.
Madagi SB, Hoskeri JH, Vedamurthy AB. Phytochemical profiling In vitro antioxidant and anti-inflammatory activities of Hopea ponga Kandelia candel Vitex leucoxylon and Rhizophora apiculata. J Pharmacogn Phytochem. 2018;7(6):1425-40.
Shettar AK, Vedamurthy AB. An In vitro approach for evaluating anthelmintic activity of Kandelia candel and Rhizophora apiculata. J Pharmacogn Phytochem. 2017;6(1):5-9.
Paul T, Ramasubbu S. The antioxidant anticancer and anticoagulant activities of acanthus ilicifolius l roots and Lumnitzera racemosa willd leaves from southeast coast of India. J Appl Pharm Sci. 2017;7(3):81-7.
Ravikumar S, Gnanadesigan M. Hepatoprotective and antioxidant activity of a mangrove plant Lumnitzera racemosa. Asian Pac J Trop Biomed. 2011;1(5):348-52. doi: 10.1016/S2221-1691(11)60078-6, PMID 23569791.
Paswan R, Jadhav B, Dhavan P, Patel P. In vitro antidiabetic activity and phytochemical analysis of Lumnitzera racemosa leaves. Education. 2015;2020.
Yusoff NA, Yam MF, Beh HK, Abdul Razak KN, Widyawati T, Mahmud R. Antidiabetic and antioxidant activities of Nypa fruticans Wurmb vinegar sample from Malaysia. Asian Pac J Trop Med. 2015;8(8):595-605. doi: 10.1016/j.apjtm.2015.07.015, PMID 26321511.
Gao M, Xiao H. Activity guided isolation of antioxidant compounds from rhizophora apiculata. Molecules. 2012;17(9):10675-82. doi: 10.3390/molecules170910675, PMID 22955456.
Prabhu VV, Guruvayoorappan C. Anti-inflammatory and anti-tumor activity of the marine mangrove Rhizophora apiculata. J Immunotoxicol. 2012;9(4):341-52. doi: 10.3109/1547691X.2012.660997, PMID 22800297.
Hong LS, Ibrahim D, Kassim J. Assessment of in vivo and In vitro cytotoxic activity of hydrolysable tannin extracted from Rhizophora apiculata barks. World J Microbiol Bio Technol. 2011;27(11):2737-40. doi: 10.1007/s11274-011-0727-1.
Laith AA. Phytochemical analysis and antimicrobial activities of mangrove plant (Rhizophora apiculata) against selected fish pathogenic bacteria. IOP Conf Ser: Earth Environ Sci. 2021;718(1):012076. doi: 10.1088/1755-1315/718/1/012076.
Chakraborty K, Raola VK. Two rare antioxidant and anti-inflammatory oleanenes from loop root asiatic mangrove Rhizophora mucronata. Phytochemistry. 2017;135:160-8. doi: 10.1016/j.phytochem.2016.12.013, PMID 28062072.
Suganthy N, Devi KP. In vitro antioxidant and anti-cholinesterase activities of Rhizophora mucronata. Pharm Biol. 2016;54(1):118-29. doi: 10.3109/13880209.2015.1017886, PMID 25856713.
Hardoko ES, Puspitasari Y, Amalia R. Study of ripe Rhizophora mucronata fruit flour as a functional food for antidiabetic. Int Food Res J. 2015;22(3):953-9.
Sur TK, Hazra AK, Bhattacharyya D, Hazra A. Antiradical and antidiabetic properties of standardized extract of sunderban mangrove Rhizophora mucronata. Pharmacogn Mag. 2015;11(42):389-94. doi: 10.4103/0973-1296.153094, PMID 25829780.
Gurudeeban S, Ramanathan T, Satyavani K. Antimicrobial and radical scavenging effects of alkaloid extracts from Rhizophora mucronata. Pharm Chem J. 2015;49(1):34-7. doi: 10.1007/s11094-015-1218-8.
Wahyuni WT, Darusman LK, Surya NK. Potency of rhizopora spp extracts as antioxidant and inhibitor of acetylcholinesterase. Procedia Chem. 2015;16:681-6. doi: 10.1016/j.proche.2015.12.009.
Miranti DI, Ichiura H, Ohtani Y. The bioactive compounds and antioxidant activity of food products of Rhizophora stylosa fruit (coffee and tea mangrove). Int J For Res. 2018;2018:1-6. doi: 10.1155/2018/2315329.
Saad S, Taher M, Susanti D, Qaralleh H, Awang AF. In vitro antimicrobial activity of mangrove plant Sonneratia alba. Asian Pac J Trop Biomed. 2012;2(6):427-9. doi: 10.1016/S2221-1691(12)60069-0, PMID 23569943.
Milon MA, Muhit MA, Goshwami D, Masud MM, Begum B. Antioxidant cytotoxic and antimicrobial activity of Sonneratia alba bark. Int J Pharm Sci Res. 2012;3(7):2233.
Morada NJ, Metillo EB, Uy MM, Oclarit JM. Antidiabetic polysaccharide from mangrove plant Sonneratia alba Sm. In: Proceedings of the international conference on Asia agriculture and animal international proceedings of chemical biological and environmental engineering; 2011. p. 197-200.
Simlai A, Rai A, Mishra S, Mukherjee K, Roy A. Antimicrobial and antioxidative activities in the bark extracts of Sonneratia caseolaris a mangrove plant. Excli J. 2014;13:997-1010. PMID 26417316.
Wetwitayaklung P, Limmatvapirat C, Phaechamud T. Antioxidant and anticholinesterase activities in various parts of Sonneratia caseolaris (l.). Indian J Pharm Sci. 2013;75(6):649-56. PMID 24591739.
Barman A, Ahmed T, Das H, Biswas B, Ali M, Acharyya R. Evaluation of antidiabetic potential of extract of Sonneratia caseolaris (l.) engl leaves against alloxan-induced diabetes in mice. TJNPR. 2021;5(1):77-83. doi: 10.26538/tjnpr/v5i1.9.
Munira MS, Islam MA, Islam MS, Koly SF, Nesa ML, Muhit MA. Phytochemical screening and comparative antioxidant activities of fractions isolated from Sonneratia caseolaris (Linn.) bark extracts. Eur J Med Plants. 2019;28(4):1-9. doi: 10.9734/ejmp/2019/v28i430141.
Bokshi B. Bioactivities of Sonneratia caseolaris (linn.) leaf and stem using different solvent systems. BJSTR. 2020 Nov;31(5):24578-82. doi: 10.26717/BJSTR.2020.31.005175.
Bokshi B, Zilani MN, Malakar A, Roy DN, Shilpi JA, Sadhu SK. Study of analgesic and antidiarrhoeal activities of Sonneratia caseolaris (linn.) leaf and stem using different solvent system. Indonesian J Pharm. 2013;24(4):253-8. doi: 10.14499/indonesianjpharm0iss0pp253-258.
Lakshmi V, Srivastava S, Mishra SK, Srivastava MN, Srivastava K, Puri SK. Antimalarial activity in Xylocarpus granatum (Koen). Nat Prod Res. 2012;26(11):1012-5. doi: 10.1080/14786419.2010.535000, PMID 21787243.
Ren JL, Zou XP, LI WS, Shen L, WU J. Limonoids containing a C1-o-C29 moiety: isolation structural modification and antiviral activity. Drugs. 2018;16(11):434. doi: 10.3390/md16110434, PMID 30400349.
Simlai A, Roy A. Biological activities and chemical constituents of some mangrove species from sundarban estuary: an overview. Pharmacogn Rev. 2013;7(14):170-8. doi: 10.4103/0973-7847.120518, PMID 24347925.
Misra S, Verma M, Mishra SK, Srivastava S, Lakshmi V, Misra Bhattacharya S. Gedunin and photogedunin of Xylocarpus granatum possess anti-filarial activity against human lymphatic filarial parasite brugia malayi in experimental rodent host. Parasitol Res. 2011;109(5):1351-60. doi: 10.1007/s00436-011-2380-x, PMID 21523424.
Uddin SJ, Grice ID, Tiralongo E. Cytotoxic effects of Bangladeshi medicinal plant extracts. Evid Based Complement Alternat Med. 2011;2011:578092. doi: 10.1093/ecam/nep111, PMID 19706693.
Prihanto AA. Cytotoxic antioxidant and antibacterial activity of methanol extract of Xylocarpus moluccensis fruit husk. In: Proceeding of the international conference on basic science held at malang indonesia. Galaxy Science Publisher; 2011. p. 2-5.
Eldeen IM, Mohamed H, Tan WN, Siong JY, Andriani Y, Tengku Muh TS. Cyclooxygenase 5-lipoxygenase and acetylcholinesterase inhibitory effects of fractions containing α-guaiene and oil isolated from the root of Xylocarpus moluccensis. Res J Med Plants. 2016;10(4):286-94. doi: 10.3923/rjmp.2016.286.294.
Chaudhry GE, Sohimi NK, Mohamad H, Zafar MN, Ahmed A, Sung YY. Xylocarpus moluccensis induces cytotoxicity in human hepatocellular carcinoma HepG2 cell line via activation of the extrinsic pathway. Asian Pac J Cancer Prev. 2021;22 Suppl 1:17-24. doi: 10.31557/APJCP.2021.22.S1.17, PMID 33576208.
Srivastava AK, Tiwari P, Srivastava SP, Srivastava R, Mishra A, Rahuja N. Antihyperglycaemic and antidyslipidemic activities in ethyl acetate fraction of fruits of marine mangrove Xylocarpus moluccensis. Int J Pharm Pharm Sci. 2014;6(1):809-26.
Muhtadi SA, Nurcahyanti W, Sutrisna EM. The potential of salam leaves (syzigium polyanthum walp.) and black cumin seed (nigella sativa linn) as candidate standarized herbal medicine of uric acid. Pharmacon. 2012;13(1):30-6.
Saroyo H, Saputri NF. Cytotoxicity of mangrove leaves (rhizophora) ethanolic extract on cancer cells. J Nutraceuticals Herb Med. 2021;4(1):43-52. doi: 10.23917/jnhm.v4i1.15657.
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