EVALUATION OF THE DETERMINATION AND IMPLEMENTATION OF BEYOND-USE DATE (BUD) TO NON-STERILE EXTEMPORANEOUS COMPOUNDED MEDICINES BY PHARMACISTS IN SUKOHARJO INDONESIA

HIDAYAH KARUNIAWATI; MARSILIA ROSA SINENSIS HI

doi:10.22159/ijap.2024.v16s6.52775

Authors

HIDAYAH KARUNIAWATI Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Indonesia
MARSILIA ROSA SINENSIS HI Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Indonesia

DOI:

https://doi.org/10.22159/ijap.2024.v16s6.52775

Keywords:

Extemporaneous compounding, Beyond use date, Pharmacist, Expired date

Abstract

Objective: This research aims to evaluate pharmacists' determination and implementation of Beyond-Use Date (BUD) for extemporaneously compounded medicines from non-sterile drugs and the factors that influence it.

Methods: This research is a non-experimental cross-sectional study that used a validated questionnaire with the cluster sampling method applied to select pharmacists. The data were analyzed statistically using the Mann-Whitney, Kruskal Wallis tests and Spearman Correlation.

Results: Of the 181 pharmacists who participated, 161 (89.0%) were aged 26–45 years, 160 (88.4%) were women, 118 (65.2%) were married, and 173 (95.6%) had a bachelor's degree with a profession. Around 75%–77% of respondents calculate BUD on the extemporaneous compounded and mark BUD on the drug label or medicine packaging. Around 80% of pharmacists inform patients about BUD, but only 65% ensure patients understand it. Age, marital status, education level, length of work experience, and income significantly influence the determination and implementation of BUD (P<0.05). Knowledge has a significant relationship with pharmacists' attitudes (r = 0.836) and behavior (r = 0.646) towards BUD

Conclusion: The role of pharmacists in determining and implementing BUD in extemporaneously compounded medicines needs to be improved to ensure maximum drug quality, safety, and optimal therapy

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