THE INFLUENCE OF MEDICATION THERAPY MANAGEMENT (MTM) ON CLINICAL OUTCOMES AND TREATMENT COMPLIANCE IN DIABETES MELLITUS PATIENTS: A SYSTEMATIC REVIEW
DOI:
https://doi.org/10.22159/ijap.2024v16s5.52471Keywords:
Pharmacist, Medication therapy management, Clinical outcomes, Medication adherenceAbstract
Objective: This systematic review aims to determine the effect of MTM carried out by pharmacists on achieving medication adherence and clinical outcomes in diabetes mellitus patients.
Methods: The journal search method was taken from PUBMED, Scopus, and Google Scholar using the keywords "diabetes mellitus", "DM", "medication therapy management", "MTM", "clinical outcome", "clinical results", "adherence", and " treatment compliance”. The research identified came from Indonesia, the United States, Ethiopia, Brazil, New Zealand, Japan, Lebanon, and Malaysia.
Results: Of the 169 studies identified, twenty-five met the inclusion and exclusion criteria, consisting of 5 RCTs, seven cohorts, and 13 quasi-experiments. MTM improves compliance and clinical outcomes of DM patients. Compliance increased from 80.5% to 87.5% (p<0.05). The average HbA1c value decreased from 10.5 to 8.2 (p<0.05), the average systolic blood pressure (SBP) decreased from 142.7 mmHg to 135.6 mmHg (p<0.05), mean diastolic blood pressure (DBP) decreased from 89.9 mmHg to 83.6 mmHg (p<0.05), and mean fasting plasma glucose (FPG) decreased from 218.5 mg/dl to 142.4 mg/dl (p<0.05).
Conclusion: Overall, this research shows that pharmacist-provided MTM services can improve clinical outcomes and medication adherence in patients with diabetes
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