MORONIC ACID: A REVIEW
DOI:
https://doi.org/10.22159/ijcpr.2021v13i5.1903Keywords:
Moronic acid, Triterpene, Synonyms, Structure, Pharmacological effectsAbstract
Moronic acid is a pentacyclic triterpenoid made up of olean-18-ene with an oxo group at position 3 and a carboxy group at position 28. It's made from an oleanane hydride. A few investigations have demonstrated that Moronic acid a wide scope of pharmacological effects such as Antidiabetic activity, Anti-AIDS agents, Chemotherapeutic agents, Virus lytic, Anti-HIV, Cytotoxic activity, Anti-herpes, Antimicrobial activity, Ribosome-loaded mRNAs.
Downloads
References
National Center for Biotechnology Information. PubChem Compound Summary for CID 489941. Available from: https://moronicacid.ncbi.nlm.gov/compound/Moronic-acid. [Last accessed on 17 Jul 2021]
Yu D, Sakurai Y, Chen CH, Chang FR, Huang L, Kashiwada Y, Lee KH. Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents. J Med Chem. 2006;49(18):5462-9. doi: 10.1021/jm0601912, PMID 16942019.
Ramírez-Espinosa JJ, Rios MY, López-Martínez S, López-Vallejo F, Medina-Franco JL, Paoli P, Camici G, Navarrete-Vázquez G, Ortiz-Andrade R, Estrada-Soto S. Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches. Eur J Med Chem. 2011;46(6):2243-51. doi: 10.1016/j.ejmech.2011.03.005, PMID 21453996.
Ramírez-Espinosa JJ, García-Jiménez S, Rios MY, Medina-Franco JL, López-Vallejo F, Webster SP, Binnie M, Ibarra-Barajas M, Ortiz-Andrade R, Estrada-Soto S. Antihyperglycemic and sub-chronic antidiabetic actions of morolic and moronic acids, in vitro and in silico inhibition of 11β-HSD. Phytomedicine. 2013;20(7):571-6. doi: 10.1016/j.phymed.2013.01.013, PMID 23453304.
Qian K, Kuo RY, Chen CH, Huang L, Morris-Natschke SL, Lee KH. Anti-AIDS agents 81. Design, synthesis, and structure–activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors. J Med Chem. 2010;53(8):3133-41. doi: 10.1021/jm901782m, PMID 20329730.
Ito J, Chang FR, Wang HK, Park YK, Ikegaki M, Kilgore N, Lee KH. Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis. J Nat Prod. 2001;64(10):1278-81. doi: 10.1021/np010211x, PMID 11678650.
Lee KH. Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. J Nat Prod. 2010;73(3):500-16. doi: 10.1021/np900821e, PMID 20187635.
Chang FR, Hsieh YC, Chang YF, Lee KH, Wu YC, Chang LK. Inhibition of the Epstein–Barr virus lytic cycle by moronic acid. Antiviral Res. 2010;85(3):490-5. doi: 10.1016/j.antiviral.2009.12.002, PMID 19969023.
Gu Q, Wang RR, Zhang XM, Wang YH, Zheng YT, Zhou J, Chen JJ. A new benzofuranone and anti-HIV constituents from the stems of Rhus chinensis. Planta Med. 2007;73(3):279-82. doi: 10.1055/s-2007-967113, PMID 17290322.
Zhang P, Hao J, Liu J, Zhang L, Sun H. Efficient synthesis of morolic acid and related triterpenes starting from betulin. Tetrahedron. 2009;65(22):4304-9. doi: 10.1016/j.tet.2009.03.100.
Cao S, Guza RC, Miller JS, Andriantsiferana R, Rasamison VE, Kingston DG. Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest. J Nat Prod. 2004;67(6):986-9. doi: 10.1021/np040058h, PMID 15217279.
Rios MY, Salina D, Villarreal ML. Cytotoxic activity of moronic acid and identification of the new triterpene 3, 4-seco-olean-18-ene-3, 28-dioic acid from Phoradendron reichenbachianum. Planta Med. 2001;67(5):443-6. doi: 10.1055/s-2001-15823, PMID 11488459.
Kurokawa M, Basnet P, Ohsugi M, Hozumi T, Kadota S, Namba T, Kawana T, Shiraki K. Anti-herpes simplex virus activity of moronic acid purified from Rhus javanica in vitro and in vivo. J Pharmacol Exp Ther. 1999;289(1):72-8. PMID 10086989.
Hostettmann-Kaldas M, Nakanishi K. Moronic acid, a simple triterpenoid keto acid with antimicrobial activity isolated from Ozoroa mucronata. Planta Med. 1979;37(4):358-60. doi: 10.1055/s-0028-1097349, PMID 538108.
Gehrke IT, Neto AT, Pedroso M, Mostardeiro CP, Da Cruz IB, Silva UF, Ilha V, Dalcol II, Morel AF. Antimicrobial activity of Schinus lentiscifolius (Anacardiaceae). J Ethnopharmacol. 2013;148(2):486-91. doi: 10.1016/j.jep.2013.04.043, PMID 23684720.
Kakegawa T, Yoshida LS, Takada M, Noguchi M, Yasukawa K, Takano-Ohmuro H. Comparison of the effects of pachymic acid, moronic acid and hydrocortisone on the polysome loading of RNAs in lipopolysaccharide-treated THP-1 macrophages. J Nat Med. 2019;73(1):190-201. doi: 10.1007/s11418-018-1260-4, PMID 30414015.
Published
How to Cite
Issue
Section
Copyright (c) 2021 RITU RANI, AJEET PAL SINGH, AMAR PAL SINGH
This work is licensed under a Creative Commons Attribution 4.0 International License.
