ANTI-INFLAMMATORY ACTIVITY OF HMG CO A REDUCTASE INHIBITORS: A COMPARATIVE STUDY
Keywords:Atorvastatin, Rosuvastatin, Membrane stabilizing, Anti-inflammatory
Objective: The purpose of the present study was to reveal the potential pleotropic anti-inflammatory activity of two hmg-co Reductase inhibitors, Rosuvastatin and atorvastatin in comparison with standard drug diclofenac.
Methods: The method used for screening anti-inflammatry activity was In vitro human red blood cell membrane stabilization method.
Results: The results of our study revealed that atorvastatin and rosuvastatin showed effective in vitro(500mcg/ml) anti-inflammatory activity when compared with the standard drug diclofenac.
Conclusion: The rosuvastatin was more potent anti-inflamatory drug when compared with atorvastatin.
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