• CICI MATHEW College of Pharmaceutical Sciences, Government Medical College, Thiruvananthapuram 695011 (India)
  • BINDU SARASWATI Corporate Research and Development Centre, HLL Lifecare Limited, Thiruvananthapuram 695017 (India)
  • NAND LAL Corporate Research and Development Centre, HLL Lifecare Limited, Thiruvananthapuram 695017 (India)
  • JOYAMMA VARKEY College of Pharmaceutical Sciences, Government Medical College, Thiruvananthapuram 695011 (India)



Anti-fungal, Rhodanine, Microdilution, Anti-bacterial


Objective: The principal objective of the study was to synthesize and evaluate the biological activities of a novel class of 5-benzylidene substituted rhodanine derivatives as antimicrobial agents.

Methods: All the synthesized compounds (D1-D10) were screened for their antimicrobial activities using microdilution methods as per the reported procedure. All compounds were evaluated as potential antimicrobial agents against gram-positive bacteria: Bacillus cereus, Staphylococcus aureus, gram negative bacteria: Escherichia coli Pseudomonas aeruginosa and Klebsiella pneumoniae Fungal cultures used in the study were Aspergillus niger, Candida albicans, Candida parapsilosis, Candida tropicalis and Candida glabrata.

Results: Compound D6 showed good antifungal activity in the MIC range 16μg/ml against Candida tropicalis and Compound D10 showed good antifungal activity in the MIC range 16μg/ml against Candida glabrata. Compounds D2 and D5 showed good antibacterial activity at 32μg/ml. all the other compounds showed moderate antibacterial activity.

Conclusion: Based on the above results, it can be concluded that the compounds may lead to the development of more potent antimicrobial drug candidates in the near future.


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How to Cite

MATHEW, C., B. SARASWATI, N. LAL, and J. VARKEY. “DESIGN, SYNTHESIS AND ANTIMICROBIAL STUDIES OF 5-BENZYLIDENE SUBSTITUTED RHODANINE CONTAINING HETEROCYCLES”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 13, no. 5, May 2021, pp. 28-34, doi:10.22159/ijpps.2021v13i5.40106.



Original Article(s)