IMPROVEMENT OF GLICLAZIDE'S DISSOLUTION RATE BY USING SURFACE SOLID DISPERSION WITH AVICEL PH 101
Keywords:
Gliclazide, Avicel PH 101, Surface solid dispersion, Dissolution rateAbstract
Objective: The aim of this study was to improve the dissolution rate of gliclazide by developing a surface solid dispersion (SSD) with Avicel PH 101 as a carrier.
Methods: Solid dispersions of gliclazide were prepared, with various ratios of gliclazide and Avicel PH 101, using the solvent evaporation method. Evaluations of the dissolution rate for each ratio were carried out in order to find the optimal formula. The physical characteristic of solid dispersions was evaluated using Fourier transform infrared (FTIR), powder X-ray diffractometry (PXRD), and Scanning Electron Microscopy (SEM). The pure gliclazide powder and its solid dispersions were then blended with excipients and compressed into tablets by using the direct compression method.
Results: The optimum solid dispersion, which consists of gliclazide and Avicel PH 101 at ratio 1:5, showed the highest dissolution rate. The infrared spectrum of the solid dispersion showed that the spectrum was a combination of gliclazide and Avicel PH 101, and that there is no differences between the spectrum of the solid dispersion and its physical mixture. The diffractogram of PXRD showed that there was a change in the gliclazide's crystalline state in solid dispersion compared to its physical mixture. Whereas, SEM characterization indicated that the solid dispersion had an adsorption of gliclazide particles on the surface of Avicel PH 101 particles in the form of small particles.
Conclusion: The preparation of surface solid dispersion with Avicel PH 101 can be used to increase the dissolution rate of gliclazide. The compression process did not alter the dissolution profile of gliclazide solid dispersion.
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References
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