EVALUATION OF ANTI-THYROID ACTIVITY OF FICUS RACEMOSA LINN BARK IN MALE RATS
Keywords:
Thyroxine, Hyperthyroidism, Ficus racemosa, Ethanolic extractAbstract
Objective: The present study was formulated in order to evaluate the Antithyroid potential of Ficus racemosa Linn bark in Albino rats.
Methods: Ficus racemosa (L.) (Family: Moraceae), is used in the mythical system for abortion, diabetes and urinary disorders. The genus of Ficus exhibited the presence of tyrosine which is responsible for the formation of T3 and T4 hormones. Hyperthyroidism was induced in experimental rats by administering Thyroxine (600µ/kg/ml) orally for 14 days. Hyper thyroid male albino rats weighing 150-200 g were treated with oral doses of 250 mg/kg, 350 mg/kg and 450 mg/kg of Ficus racemosa ethanolic extract for a period of 21 days. Methimazole 0.04% w/v for 21 days served as the standard.
Results: In this study, morphological assessment demonstrated that thyroxine treated gathering demonstrates increased levels of Triiodo-L-thyronine and L-thyroxine. Simultaneous administration of ethanolic extracts of Ficus racemosa bark lowered the increased levels. The decrease in the levels of T3 and T4 by the extracts was compared with the reference drug Methimazole.
Conclusion: The Antithyroid activity is evident from the decreased T3 and T4 levels. It can be said that Ficus racemosa significantly by virtue of the presence of tyrosine, which may be useful for further molecular studies to determine the exact mechanism for its Antithyroid activity.
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