• Aminah Dalimunthe Faculty of Pharmacy, University of Sumatera Utara
  • Urip Harahap
  • Rosidah .
  • Pandapotan Nasution M


Objective: The aims of this study was to evaluate the diuretic activity of different leaves extract of Picria fel-terrae using n-hexane, ethylacetate and ethanol as solvents.


Methods: The diuretic activity of the extracts were evaluated by determining urine volume and electrolyte (Na+, K+) concentration in male Wistar rats at a various dose extract of  400 and 800 mg/kg bw. Furosemide (10 mg/kb bw) was used as reference drug and cmc-Na 1% was as normal control.


Results: Urine volume was significan increase by n-hexane extract at dose 800 mg/kg bw in comparison to normal control groups. The excretion of sodium was also increase by the all extract. The n-hexane extract showed better diuretic effect in comparison to other extract.


Conclusion: The leaves extracts of Picria fel-terrae have diuretic activity


Keyword: Picria fel-terrae Lour, diuresis, urine electrolyte



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How to Cite

Dalimunthe, A., U. Harahap, R. ., and P. Nasution M. “EVALUATION OF DIURETIC ACTIVITY OF PICRIA FEL-TERRAE LOUR LEAVES EXTRACTS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 8, no. 4, July 2015, pp. 204-5, https://journals.innovareacademics.in/index.php/ajpcr/article/view/6405.



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