RESEARCH AND DEVELOPMENT IN WOUND MANAGEMENT PRODUCTS: A BRIEF REVIEW

Authors

  • Surya Geetha V Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, JSS Medical Institutions Campus, Sri Shivarathreeshwara Nagara, Mysore - 570 015, Karnataka, India.
  • Vishal Gupta N Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, JSS Medical Institutions Campus, Sri Shivarathreeshwara Nagara, Mysore - 570 015, Karnataka, India.
  • Gowda Dv Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, JSS Medical Institutions Campus, Sri Shivarathreeshwara Nagara, Mysore - 570 015, Karnataka, India.
  • Kulkarni Pk Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, JSS Medical Institutions Campus, Sri Shivarathreeshwara Nagara, Mysore - 570 015, Karnataka, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i6.23541

Keywords:

Topical wound care, Wet dressings, Sulfadiazine, Flamazine silvadene, Staphylococcus aureus

Abstract

Wound can be defined as any process which leads to the disruption of the normal architecture of a tissue. They may be closed or open, for example, abrasions, lacerations, avulsions, ballistic and excised, or surgical wounds. Successful wound care includes advancing patient local and systemic conditions in conjunction with a perfect injury healing condition. Numerous wide assortments of dressing materials are accessible both for extreme and persistent non-healing wounds. A wide range of wound healing products have been produced to impact this injury condition to give a non-pathogen, ensured, and clammy region for healing to happen. A perfect injury dressing ought to limit loss of protein, electrolytes, and liquids from twisted and to diminish pain and contamination alongside wound healing. More current products are as of now being utilized to supplant or enlarge different substrates in the injury healing period. There is a sharp complexity to prior routine of wound administration, where the injury is permitted to dry, yet the present advancement was to move forward to the idea of wet injury recovering. This review of the present wounding periphery in wound recovery occurs at the most recent utilizations of silver and the employments of negative pressure wound gadgets, propelled dressings and skin substitutes, and biologic injury items including development of hydrogels and hyperbaric oxygen as an aid in wound mending. With the advancement of accessible dressings, the objective is to locate the most proper methodology or blend of modalities to optimize wound healing.

Downloads

Download data is not yet available.

Author Biography

Surya Geetha V, Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, JSS Medical Institutions Campus, Sri Shivarathreeshwara Nagara, Mysore - 570 015, Karnataka, India.

Professor

References

Santram L, Gautam PV. Relevance and perspectives of experimental wound models in wound healing research. Asian J Pharm Clin Res 2017;10:57-62.

Priyadarshni CK, Mahalingam PU. Antimicrobial and anticancer activity of silver nanoparticles from edible mushroom: A review. Asian J Pharm Clin Res 2017;10:37-40.

Mostafalu P, Akbari M, Alberti KA, Xu Q, Khademhosseini A, Sonkusale SR. A toolkit of thread-based microfluidics, sensors, and electronics for 3D tissue embedding for medical diagnostics. Microsyst Nanoeng 2016;39:317-22.

Mchugh GL, Moellering R, Hopkins C, Swartz M. Salmonella typhimurium resistant to silver nitrate, chloramphenicol, and ampicillin. Lancet 2012;305:235-40.

Demidova-Rice TN, Hamblin MR, Herman IM. Acute and impaired wound healing: Pathophysiology and current methods for drug delivery, Part 1: Normal and chronic wounds: Biology, causes, and approaches to care. Int J Adv Skin Wound Care 2012;25:304.

Suzuki Y, Nishimura Y, Tanihara M, Suzuki K, Nakamura T, Shimizu Y, et al. Evaluation of a novel alginate gel dressing: Cytotoxicity to fibroblasts in vitro and foreign body reaction in pig skin in vivo. J Biomed Mater Res A 2010;39:317-22.

Brem H, Balledux J, Bloom T, Kerstein MD, Hollier L. Healing of diabetic foot ulcers and pressure ulcers with human skin equivalent: A new paradigm in wound healing. Arch Surg 2000;135:627-34.

Sprung P, Hou Z, Ladin DA. Hydrogels and hydrocolloids: An objective product comparison. Ostomy Int J Wound Manage 2010;44:36-42.

Cianfarani F, Tommasi R, Failla CM, Viviano MT, Annessi G, Papi M, et al. Granulocyte/macrophage colony stimulating factor treatment of human chronic ulcers promotes angiogenesis associated with de novo vascular endothelial growth factor transcription in the ulcer bed. Br J Dermtol 2006;154:34-41.

Da Costa RM, Jesus FM, Aniceto C, Mendes M. Randomized, double blind, placebo controlled, dose ranging study of granulocyte macrophage colony stimulating factor in patients with chronic venous leg ulcers. J Wound Repair Reg 2011;7:17-25.

Cruciani M, Lipsky BA, Mengoli C, De Lalla F. Are granulocyte colony-stimulating factors beneficial in treating diabetic foot infections? Diabetes Care 2005;28:454-60.

Bennett SA, Birnboim HC. Receptor-mediated and protein kinase-dependent growth enhancement of primary human fibroblasts by platelet activating factor. Mol Carcinog 2012;20:366-75.

Steed DL. Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity ulcers. Ind J Plastic Reconstruct Surg 2006;117:143S-9S.

Margolis DJ, Bartus C, Hoffstad O, Malay S, Berlin JA. Effectiveness of recombinant human platelet derived growth factor for the treatment of diabetic neuropathic foot ulcers. J Wound Repair Reg 2005;13:531- 6.

Hom DB, Manivel JC. Promoting healing with recombinant human platelet derived growth factor-bb in a previously irradiated problem wound. Laryngoscope 2003;113:1566-71.

Langemo DK, Black J. Pressure ulcers in individuals receiving palliative care: A national pressure ulcer advisory panel. Adv Skin Wound Care 2010;23:59-72.

Boykin JV. Hyperbaric oxygen therapy: A physiological approach to selected problem wound healing. J Wound Repair Reg 2005;13:531-6.

Bauer SM, Bauer RJ, Velazquez OC. Angiogenesis, vasculogenesis, and induction of healing in chronic wounds. J Vasc Endovasc Surg 2005;39:293-306.

Velazquez OC. Angiogenesis and vasculogenesis: Inducing the growth of new blood vessels and wound healing by stimulation of bone marrow-derived progenitor cell mobilization and homing. J Vasc Surg 2007;45:A39-47.

Bradley M, Cullum N, Nelson EA, Petticrew M, Sheldon T, Torgerson D. Systematic reviews of wound care management:(2) dressings and topical agents used in the healing of chronic wounds. Int J Wound Care 2011;3:305-56.

Rubin JR, Alexander J, Plecha EJ, Marman C. Unna’s boot Vs polyurethane foam dressings for the treatment of venous ulceration: A randomized prospective study. Arch Surg 2009;125:489-90.

Kannon GA, Garrett AB. Moist wound healing with occlusive dressings. J Dermtol Surg 2013;21:583-90.

Agren MS. Four alginate dressings in the treatment of partial thickness wounds: A comparative experimental study. Br J Plastic Surg 2009;49:129, 34.

Doyle JW, Roth TP, Smith RM, Li YQ, Dunn RM. Effect of calcium alginate on cellular wound healing processes modeled in vitro. J Biomed Mater Res A 2011;32:561-8.

Suzuki Y, Nishimura Y, Tanihara M, Suzuki K, Nakamura T, Shimizu Y, et al. Evaluation of a novel alginate gel dressing: Cytotoxicity to fibroblasts in vitro and foreign body reaction in pig skin in vivo. J Biomed Mater Res A 2010;39:317-22.

Sprung P, Hou Z, Ladin DA. Hydrogels and hydrocolloids: An objective product comparison. Ostomy Int J Wound Manage 2010;44:36-42.

Banks V, Hagelstein S, Thomas N, Bale S, Harding KG. Comparing hydrocolloid dressings in management of exuding wounds. Br J Nurs 2013;8:6406.

Sarabahi S. Recent advances in topical wound care. Ind J Plastic Surg 2012;45:379.

Marga F, Neagu A, Kosztin I, Forgacs G. Developmental biology and tissue engineering. Birth Defects Res C Embryo Today 2007;81:320-8.

Sarabahi S. Recent advances in topical wound care. Ind J Plastic Surg 2012;45:379.

Demidova-Rice TN, Hamblin MR, Herman IM. Acute and impaired wound healing: Pathophysiology and current methods for drug delivery, Part 1: Normal and chronic wounds: Biology, causes, and approaches to care. Int J Adv Skin Wound Care 2012;25:304.

Liesenfeld B, Toreki W, Moore DN, Leander S, Schultz G, Lane D. Development of a novel peroxide based antimicrobial hydrocolloid for wound dressings. Int J Repair Reg 2016;24:345.

Luo X, Zhang H, Cao Z, Cai N, Xue Y, Yu F. A simple route to develop transparent doxorubicin-loaded nanodiamonds/cellulose nanocomposite membranes as potential wound dressings. Carbohydr Polym 2016;143:231-8.

Bonn D. Maggot therapy: An alternative for wound infection. Lancet 2000;356:1174.

Thomas S, Andrews A, Jones M. The use of larval therapy in wound management. J Wound Care 2009;7:521.

Higley HR, Ksander GA, Gerhardt CO, Falanga V. Extravasation of macromolecules and possible trapping of transforming growth factor-beta in venous ulceration. Br J Dermatol 1995;132:79-85.

Trengove NJ, Stacey MC, Macauley S, Bennett N, Gibson J, Burslem F, et al. Analysis of the acute and chronic wound environments: The role of proteases and their inhibitors. Int J Wound Repair Reg 2014;7:442- 52.

Trengove NJ, Ohmann HB, Stacey MC. Mitogenic activity and cytokine levels in non-healing and healing chronic leg ulcers. Int J Wound Repair Reg 2009;8:13-25.

Greenhalgh DG. The role of growth factors in wound healing. J Trauma 1996;41:159-67.

Mouës CM, Heule F, Hovius SE. A review of topical negative pressure therapy in wound healing: Sufficient evidence? Am J Surg 2011;201:544-56.

Brem H, Balledux J, Bloom T, Kerstein MD, Hollier L. Healing of diabetic foot ulcers and pressure ulcers with human skin equivalent: Int J Wound Healing Arch Surg 2010;135:627-34.

Margolis DJ, Bartus C, Hoffstad O, Malay S, Berlin JA. Effectiveness of recombinant human platelet derived growth factor for the treatment of diabetic neuropathic foot ulcers. J Wound Repair Reg 2005;13:531-6.

Mian M, Beghe F, Mian E. Collagen as a pharmacological approach in wound healing. Int J Tissue React 1992;14:1-9.

Wilson JM, Baines R, Babu ED, Kelley CJ. A role for topical insulin in the management problematic surgical wounds. J Wound Care 2008;90:160.

Zhang XJ, Wu X, Wolf SE, Hawkins HK, Chinkes DL, Wolfe RR. Local insulin-zinc injection accelerates skin donor site wound healing. J Surg Res 2007;142:906.

Greenway SE, Filler LE, Greenway FL. Topical insulin in wound healing: A randomised, double-blind, placebo-controlled trial. J Wound Care 2012;10:526-8.

Rezvani O, Shabbak E, Aslani A, Bidar R, Jafari M, Safarnezhad S, et al. A randomized, double-blind, placebo-controlled trial to determine the effects of topical insulin on wound healing. Ostomy Wound Manage 2009;55:22-8.

Chen X, Liu Y, Zhang X. Topical insulin application improves healing by regulating the wound inflammatory response. Int J Wound Repair Reg 2012;20:42534.

Baumann LS, Md JS. The effects of topical vitamin E on the cosmetic appearance of scars. Int J Dermotol Surg 1999;25:311-5.

Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, et al. Regeneration of fat cells from myofibroblasts during wound healing. J Sci Tech 2017;36:ai8792.

Mostafalu P, Akbari M, Alberti KA, Xu Q, Khademhosseini A, Sonkusale SR. A toolkit of thread-based microfluidics, sensors, and electronics for 3D tissue embedding for medical diagnostics. Microsyst Nanoeng 2016;39:317-22.

Xiao Y, Reis LA, Feric N, Knee EJ, Gu J, Cao S, et al. Diabetic wound regeneration using peptide-modified hydrogels to target re-epithelialization. J Natl Acad Life Sci 2016;113:E5792-801.

Hansen SL, Voigt DW, Wiebelhaus P, Paul CN. Using skin replacement products to treat burns and wounds. J Adv Skin Wound Care 2009;14:37- 46.

Pham C, Greenwood J, Cleland H, Woodruff P, Maddern G. Bioengineered skin substitutes for the management of burns: A systematic review. J Burn Care Res 2014;33:946-57.

Noordenbos J, Doré C, Hansbrough JF. Safety and efficacy of trans cyte for the treatment of partial-thickness burns. J Burn Care Res 2013;20:275-81.

Demling RH, DeSanti L. Closure of partial-thickness facial burns with a bioactive skin substitute in the major burn population decreases the cost of care and improves outcome. J Clin Res Pract 2012;14:230-4.

Bonn D. Maggot therapy: An alternative for wound infection. Lancet 2000;356:1174.

Thomas S, Andrews A, Jones M. The use of larval therapy in wound management. J Wound Care 2009;7:521.

Higley HR, Ksander GA, Gerhardt CO, Falanga V. Extravasation of macromolecules and possible trapping of transforming growth factor-beta in venous ulceration. Br J Dermatol 1995;132:79-85.

Trengove NJ, Stacey MC, Macauley S, Bennett N, Gibson J, Burslem F, et al. Analysis of the acute and chronic wound environments: The role of proteases and their inhibitors. Int J Wound Repair Reg 2014;7:442- 52.

Trengove NJ, Ohmann HB, Stacey MC. Mitogenic activity and cytokine levels in non-healing and healing chronic leg ulcers. Int J Wound Repair Reg 2009;8:13-25.

Greenhalgh DG. The role of growth factors in wound healing. J Trauma 1996;41:159-67.

Mouës CM, Heule F, Hovius SE. A review of topical negative pressure therapy in wound healing: Sufficient evidence? Am J Surg 2011;201:544-56.

Brem H, Balledux J, Bloom T, Kerstein MD, Hollier L. Healing of diabetic foot ulcers and pressure ulcers with human skin equivalent: Int J Wound Healing Arch Surg 2010;135:627-34.

Margolis DJ, Bartus C, Hoffstad O, Malay S, Berlin JA. Effectiveness of recombinant human platelet derived growth factor for the treatment of diabetic neuropathic foot ulcers. J Wound Repair Reg 2005;13:531-6.

Mian M, Beghe F, Mian E. Collagen as a pharmacological approach in wound healing. Int J Tissue React 1992;14:1-9.

Wilson JM, Baines R, Babu ED, Kelley CJ. A role for topical insulin in the management problematic surgical wounds. J Wound Care 2008;90:160.

Zhang XJ, Wu X, Wolf SE, Hawkins HK, Chinkes DL, Wolfe RR. Local insulin-zinc injection accelerates skin donor site wound healing. J Surg Res 2007;142:906.

Greenway SE, Filler LE, Greenway FL. Topical insulin in wound healing: A randomised, double-blind, placebo-controlled trial. J Wound Care 2012;10:526-8.

Rezvani O, Shabbak E, Aslani A, Bidar R, Jafari M, Safarnezhad S, et al. A randomized, double-blind, placebo-controlled trial to determine the effects of topical insulin on wound healing. Ostomy Wound Manage 2009;55:22-8.

Chen X, Liu Y, Zhang X. Topical insulin application improves healing by regulating the wound inflammatory response. Int J Wound Repair Reg 2012;20:42534.

Baumann LS, Md JS. The effects of topical vitamin E on the cosmetic appearance of scars. Int J Dermotol Surg 1999;25:311-5.

Published

07-06-2018

How to Cite

Geetha V, S., V. Gupta N, G. Dv, and K. Pk. “RESEARCH AND DEVELOPMENT IN WOUND MANAGEMENT PRODUCTS: A BRIEF REVIEW”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 6, June 2018, pp. 17-24, doi:10.22159/ajpcr.2018.v11i6.23541.

Issue

Section

Review Article(s)

Most read articles by the same author(s)