FABRICATION AND EVALUATION OF SOLID DISPERSION CONTAINING GLIBENCLAMIDE
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i8.26236Keywords:
Glibenclamide, Pluronic F-127, Solid dispersion, DiabetesAbstract
 Objective: The aim of the present study was to increase the dissolution rate of glibenclamide (GLIB) by molecular dispersion of drug in the polymeric matrix of Pluronic F-127.
Methods: GLIB-loaded solid dispersions were formulated by fusion method. The formulated solid dispersions were characterized for scanning electron microscopy (SEM), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), and evaluated for percentage yield, drug content, solubility, and in vitro dissolution profile, and stability studies were conducted as per International Conference on Harmonisation guidelines Q1A in stability chamber, both at intermediate and accelerated conditions.
Results: Both XRD and DSC studies suggested that crystalline GLIB was converted to amorphous form after loading into carrier. SEM studies revealed that the prepared solid dispersions were in the form of irregular particles with the absence of crystalline material. Due to this conversion of crystalline to amorphous state, formulated solid dispersions had shown improved dissolution rate profile of GLIB and stability studies suggested that formulated solid dispersions showed no significant changes in appearance and also in drug content.
Conclusion: Thus, from the obtained results, it can be concluded that dissolution profile of GLIB can be improved by formulating as solid dispersion.
Downloads
References
Ford JL. The current status of solid dispersions. Pharm Acta Helv 1986;61:69-88.
Akiladevi D, Shanmugapandiyan P, Jebasingh D, Basak S. Preparation and evaluation of paracetamol by solid dispersion technique. Int J Pharm Pharm Sci 2011;3:188-91.
Sharma DK. Solubility enhancement strategies for poorly water-soluble drugs in solid dispersions: A review. Asian J Pharm 2016;1:9-19.
Savjani KT, Gajjar AK, Savjani JK. Drug solubility: Importance and enhancement techniques. ISRN Pharm 2012;2012:1-10.
Serajuddin A. Solid dispersion of poorly water-soluble drugs: Early promises, subsequent problems, and recent breakthroughs. J Pharm Sci 1999;88:1058-66.
Dhirendra K, Lewis S, Udupa N, Atin K. Solid dispersions: A Review. Pak J Pharm Sci 2009;22:234-46.
Allawadi D, Singh N, Singh S, Arora S. Solid dispersions: A review on drug delivery system and solubility enhancement. Int J Pharm Sci Res 2013;4:2094-105.
Kurmi R, Mishra DK, Jain DK. Solid dispersion: A novel means of solubility enhancement. J Crit Rev 2016;3:1-8.
Alkarib SY, Nur AO. Gastroretentive controlled release glibenclamide oral tablet formulation. Am J Adv Drug Deliv 2017;5:19-37.
Sheppard DN, Robinson KA. Mechanism of glibenclamide inhibition of cystic fibrosis transmembrane conductance regulator Cl-channels expressed in a murine cell line. J Physiol 1997;503:333-46.
Yadav S, Veena M, Srinivas M. Solid dispersion technique to enhance the solubility and dissolution rate of Aripiprazole by fusion method. Int J Pharm Pharm Sci 2016;8:187-92.
Preethi GB, Banerjee S, Shivakumar HN, Kumar MR. Formulation of fast-dissolving tablets of Doxazosin mesylate drug by direct compression method. Int J Appl Pharm 2017;9:22-8.
Kar A, Ahmed AB. Enhancement of solubility and dissolution of ibuprofen by solid dispersion technique and formulation of sustained release tablets containing the optimised batch of solid dispersion. Int J Curr Pharm Res 2017;9:37-44.
Kaushik S, Pathak K. Development and evaluation of monolithic osmotic tablet of Ketoprofen: Using solid dispersion technique. Int J Pharm Pharm Sci 2016;8:41-7.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
