PROTECTIVE EFFECT OF CURCUMA LONGA ADMINISTRATION ON LUNG OF MICE EXPOSED TO CADMIUM
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i10.29010Keywords:
Oxidative damage, Antioxidant enzymes, Ameliorate and toxicityAbstract
Objective: Cadmium (Cd) is a toxic heavy metal which is introduced into the environment by various anthropogenic and natural activities. It can cause various health problems even at low concentration by inducing oxidative damage in tissues of organisms. Nowadays, the focus has been raised toward the use of herbal treatment against the heavy metal toxicity. Hence, the present study was aimed to investigate the protective effect of curcumin (Cur) against Cd-induced toxicity in the lung of albino mice.
Materials and Methods: Albino mice were divided into 4 groups and 5 mice were kept in each group. The experiment was carried out for 15 and 45 days. Group 1 mice were kept as control. Group 2 mice were given an oral dose of 1mg/kg body weight of Cd on alternate days. Group 3 mice were administered an oral dose of 1mg/kg body weight of Cd on alternate days and 100 mg/kg body weight of Cur daily. Group 4 mice were received an oral dose of 100 mg/kg body weight of Cur daily. Autopsies were done on 15 and 45 days post-treatment.
Result: Biochemical observations showed an increased level of lipid peroxidation and decreased the activity of antioxidant enzymes, i.e., superoxide dismutase, catalase, and glutathione peroxidase. However, Cur administration improved the level of malondialdehyde and oxidative stress in lung tissue by its antioxidant activity. Furthermore, cotreatment of Cd and Cur ameliorated the antioxidant level.
Conclusion: The results of the present experiment showed the protective action of Cur on the Cd-induced oxidative damage in the lung of mice.
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Lopes TM, Barcarolli IF, de Oliveira CB, de Souza MM, Bianchini A. Effect of copper onion content in isolated mantle cells of the marine clam Mesodesma mactroides. Environ Toxicol Chem 2011;30:1582-5.
Attia AM, Ibrahim FA, Abdel-Latif NA, Aziz SW. Antioxidant effect of curcumin against cadmium chloride-induced oxidative stress in blood of rats. J Pharm Phytother 2014;6:33-40.
Sarkar AG, Ravindran, Krishnamurthy V. A brief review on the effect of cadmium toxicity: From cellular to organ level. Int J Bio Technol Res 2013;3:17-36.
Chatterjee S, Kundu S, Sengupta S, Bhattacharyya A. Divergence to apoptosis from ROS induced cell cycle arrest: Effect of cadmium. Mutat Res 2009;663:22-31.
Choong G, Liu Y, Xiao W, Templeton DM. Cadmium-induced glutathionylation of actin occurs through a ROS-independent mechanism: Implications for cytoskeletal integrity. Toxicol Appl Pharmacol 2013;272:423-30.
Nunes B, Caldeira C, Pereira JL, Gonçalves F, Correia AT. Perturbations in ROS-related processes of the fish Gambusia holbrooki after acute and chronic exposures to the metals copper and cadmium. Environ Sci Pollut Res Int 2015;22:3756-65.
Wei X, Qi Y, Zhang X, Gu X, Cai H, Yang J, et al. ROS act as an upstream signal to mediate cadmium-induced mitophagy in mouse brain. Neurotoxicology 2015;46:19-24.
Jemai H, Messaoudi I, Chaouch A, Kerkeni A. Protective effect of zinc supplementation on blood antioxidant defense system in rats exposed to cadmium. J Trace Elem Med Biol 2007;21:269-73.
Newairy AA, El-Sharaky AS, Badreldeen MM, Eweda SM, Sheweita SA. The hepatoprotective effects of selenium against cadmium toxicity in rats. Toxicology 2007;242:23-30.
Ohta H, Cherian MG. Gastrointestinal absorption of cadmium and metallothionein. Toxicol Appl Pharmacol 1991;107:63-72.
Nordberg GF. Historical perspectives on cadmium toxicology. Toxicol Appl Pharmacol 2009;238:192-200.
Andersen O, Nielsen JB, Nordberg GF. Factors affecting the intestinal uptake of cadmium from the diet. In: Nordberg GF, Herber RF, Alessio L, editors. Cadmium and the environment. Lyon: IARC; 1992. P. 173-87.
Cadmium and Cadmium Compounds. IARC Monogr Eval Carcinog Risks Hum 1993;58:119-237.
Bressler JP, Olivi L, Cheong JH, Kim Y, Bannona D. Divalent metal transporter 1 in lead and cadmium transport. Ann N Y Acad Sci 2004;1012:142-52.
Seidal K, Jörgensen N, Elinder CG, Sjögren B, Vahter M. Fatal cadmium-induced pneumonitis. Scand J Work Environ Health 1993;19:429 31.
Barbee JY Jr. Prince TS. Acute respiratory distress syndrome in a welder exposed to metal fumes. South Med J 1999;92:510-2.
Sinha R, Anderson DE, McDonald SS, Greenwald P. Cancer risk and diet in India. J Postgrad Med 2003;49:222-8.
Ammon HP, Wahl MA. Pharmacology of Curcuma longa. Planta Med 1991;57:1-7.
Chattopadhyay I, Biswas K, Bandopadhyay U, Banerjee R. Turmeric and curcumin: Biological actions and medicinal applications. Curr Sci 2004;87:44-53.
Suzuki M, Nakamura T, Iyoki S, Fujiwara A, Watanabe Y, Mohri K, et al. Elucidation of anti-allergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities. Biol Pharm Bull 2005;28:1438-43.
Kurup VP, Barrios CS, Raju R, Johnson BD, Levy MB, Fink JN, et al. Immune response modulation by curcumin in a latex allergy model. Clin Mol Allergy 2007;5:1.
Nazam Ansari M, Bhandari U, Pillai KK. Protective role of curcumin in myocardial oxidative damage induced by isoproterenol in rats. Hum Exp Toxicol 2007;26:933-8.
Kurup VP, Barrios CS. Immunomodulatory effects of curcumin in allergy. Mol Nutr Food Res 2008;52:1031-9.
Abu-Taweel GM. Curcumin attenuates lead (Pb)–induced neurobehaviorl and neurobiochemical dysfunction: A review. Int J Pharm Pharm Sci 2018;10:23-8.
Biswas SK, McClure D, Jimenez LA, Megson IL, Rahman I. Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: Mechanism of free radical scavenging activity. Antioxid Redox Signal 2005;7:32-41.
Kamel R, Hashim AA, Ali SA. Palliative effect of curcumin On Stzinduced diabetes in rats. Int J Pharm Pharm Sci 2014;6:558-63.
Wilbur KM, Bernheim F, Shapiro OW. The thiobarbituric acid reagent as a test for the oxidation of unsaturated fatty acids by various agents. Arch Biochem 1949;24:305-13.
Das K, Samantha L, Chinoy GB. A modified spectrophotometric assay for superoxide dismutase using nitrite formation by superoxide radicals. Indian J Biochem Biophys 2000;37:201-4.
Aebi HE. In: Bergmeyr HU, editor. Catalase in Methods of Enzymatic Analysis. Weinheim: Verlag Chemie; 1984. p. 273-86.
Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: Biochemical role as a component of glutathione peroxides. Science 1973;179:588-90.
Del Rio D, Stewart AJ, Pellegrini N. A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis 2005;15:316-28.
Karaca S, Eraslan G. The effects of flaxseed oil on cadmium-induced oxidative stress in rats. Biol Trace Elem Res 2013;155:423-30.
Manca D, Ricard AC, Trottier B, Chevalier G. Studies on lipid peroxidation in rat tissues following administration of low and moderate doses of cadmium chloride. Toxicology 1991;67:303-23.
Rana SV, Verma S. Protective effects of GSH, vitamin E, and selenium on lipid peroxidation in cadmium-fed rats. Biol Trace Elem Res 1996;51:161-8.
Kofod P, Bauer R, Danielsen E, Larsen E, Bjerrum MJ 113Cd-NMR investigation of a cadmium-substituted copper, zinc-containing superoxide dismutase from yeast. Eur J Biochem 1991;198:607-11.
Casalino E, Calzaretti G, Sblano C, Landriscina C. Molecular inhibitory mechanisms of antioxidant enzymes in rat liver and kidney by cadmium. Toxicology 2002;179:37-50.
Cuypers A, Plusquin M, Remans T, Jozefczak M, Keunen E, Gielen H, et al. Cadmium stress: An oxidative challenge. Biometals 2010;23:927-40.
Kim CY, Lee MJ, Lee SM, Lee WC, Kim JS. Effect of melatonin on cadmium-induced hepatotoxicity in male sprague-dawley rats. Tohoku J Exp Med 1998;186:205-13.
Morales AI, Vicente-Sa´nchez C, Sandoval JM. Protective effect of quercetin on experimental chronic cadmium nephrotoxicity in rats is based on its antioxidant properties. Food Chem Toxicol 2006;44:2092-100.
Messaoudi I, El Heni J, Hammouda F, Saïd K, Kerkeni A. Protective effects of selenium, zinc, or their combination on cadmium-induced oxidative stress in rat kidney. Biol Trace Elem Res 2009;130:152-61.
De Castro MA, Neto FF, Lima LM, Da Silva FM, De Oliveira RJ, Zanesco A. Production of free radicals and catalase activity during acute exercise training in young men. Biol Sport 2009;26:113-8.
Yalin S, Comelekoglu U, Bagis S, Sahin NO, Ogenler O, Hatungil R, et al. Acute effect of single-dose cadmium treatment on lipid peroxidation and antioxidant enzymes in ovariectomized rats. Ecotoxicol Environ Saf 2006;65:140-4.
Dallak M. Camal’s mik protects against cadmium chloride induced hypocromic microcytic anemia and oxidative stress in red blood cells of white albino rats. Am J Pharmacol Toxicol 2009;4:136-43.
Jamakala O, Rani UA. Amelioration effect of zinc and iron supplementation on selected oxidative stress enzymes in liver and kidney of cadmium-treated male albino rat. Toxicol Int 2015;22:1-9.
Lazarus M, Orct T, Aladrovic J, Ljubic BB, Jurasovic J, Blanusa M. Effect of selenium pretreatment on antioxidative enzymes and lipid peroxidation in Cd-exposed suckling rats. Biol Trace Elem Res 2011;142:611-22.
Ognjanović BI, Marković SD, Pavlović SZ, Zikić RV, Stajn AS, Saicić ZS, et al. Effect of chronic cadmium exposure on antioxidant defense system in some tissues of rats: Protective effect of selenium. Physiol Res 2008;57:403-11.
Kanbur M, Eraslan G, Silici S. Antioxidant effect of propolis against exposure to propetamphos in rats. Ecotoxicol Environ Saf 2009;72:909-15.
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