• Harikesh Maurya Department of Pharmaceutical Sciences, Kumaun University, Bhimtal Campus, Bhimtal, Nainital, Uttarakhand, India
  • Tirath Kumar Department of Pharmaceutical Sciences, Kumaun University, Bhimtal Campus, Bhimtal, Nainital, Uttarakhand, India



Polyherbal dispersible tablet, Micromeritics, Dispersion time, Superdisintegrants, Crospovidone, IR compatibility


Objective: The study was designed as formulation, standardization, and evaluation of polyherbal dispersible tablet prepared for the management of kidney disorders. To overcome the problem of dyspepsia in geriatric patients by the use of polyherbal dispersible tablets.

Methods: Dispersible tablets were prepared using aqueous root extract powder of the selected plant viz. A. officinalis, B. diffusa, C. papaya, C. fistula, C. intybus, F. hispida, F. indica, C. nurvala, S. virgaurea, and V. negundo with the help of superdisintegrant addition technique using crospovidone, sodium starch glycolate and croscarmellose sodium in different percentage. Evaluation assessments such as the substantial test, weight variation, hardness, friability, content uniformity, disintegration, in vitro dispersion, stability study and IR compatibility were carried out.

Results: Micromeritics of extracts powder were determined for all formulation, which signifying good flow properties. The substantial examination was established, which comply with official requirements for uniformity test, and the drug content was close to 100% in all formulations. Disintegration time was observed for all formulation in which the polyherbal formulation-3 (PHF-3) showing 1.10±0.10 min; during in vitro dispersion time, all formulation showed appropriate dispersion in which the PHF-3 captivating 2.00±0.45 min only. The IR compatibility shows none chemical interaction between the extracts and excipients.

Conclusion: The PHF-3 showed satisfactory disintegration and in vitro dispersion time due to crospovidone and reported as the best formulation. The stability study and IR compatibility validate the PHF may represent new easily swallow dispersible tablet that may enhance drug permeability and advance bioavailability for nephrotic patients.



Download data is not yet available.


Hankey A. Ayurveda and the battle against chronic disease: an opportunity for ayurveda to go mainstream? J Ayurveda Integ Med 2010;1:9–12.

Chaudhary A, Singh N. Contribution of world health organization in the global acceptance of ayurveda. J Ayurveda Integ Med 2011;2:179–86.

Parasuraman S, Thing GS, Dhanaraj SA. Polyherbal formulation: concept of ayurveda. Pharmacogn Rev 2014;8:73–80.

Pandey MM, Rastogi S, Rawat AKS. Indian traditional ayurvedic system of medicine and nutritional supplementation. J Evidence Based Complementary Altern Med 2013:1–12.

Garg V, Dhar VJ, Sharma A, Dutt R. Facts about standardization of herbal medicine: a review. Zhong Xi Yi Jie He Xue Bao 2012;10:1077-83.

Awasthi H, Mani D, Nath R, Nischal A, Usman K, Khattri S. Standardization, preparation and evaluation of an Ayurvedic polyherbal formulation in a capsule dosage form suitable for use in clinical trials. Indo Am J Pharm Res 2014;4:4093-9.

Mathew L, Babu S. Phytotherapy in India: the transition of tradition to technology. Curr Bot 2011;2:17–22.

Srivastava S, Lal VK, Pant KK. Polyherbal formulations based on Indian medicinal plants as antidiabetic phytotherapeutics. Phytopharmacology 2012;2:1-15.

Kapoor VK, Singla S. Herb-drug interactions–an update on synergistic interactions. J Alt Med Res 2015;1:1-11.

Gurley BJ. Pharmacokinetic herb-drug interactions (Part 1): Origins, mechanisms, and the impact of botanical dietary supplements. Planta Med 2012;78:1478–89.

Rawat R, Vashistha DP. Common herbal plant in Uttarakhand, used in the popular medicinal preparation in ayurveda. Int J Pharmacogn Phytochem Res 2011;3:64–73.

Kulkarni, Raghavendra G. Extraction of roots of quintics by division method. Int J Mathem Edu Sci Tech 2009;40:407–10.

Rajab NA. Preparation and in vitro evaluation of lacidipine oral liquid-solid tablet as an approach of solubility and dissolution rate enhancement. Int J Appl Pharm 2018;10:145-53.

Parfati N, Rani KC, Charles N, Geovanny V. Preparation and evaluation of atenolol-β-cyclodextrin orally disintegrating tablets using co-process crospovidone-sodium starch glycolate. Int J Appl Pharm 2018;10:190-94.

Agnihotri A, Singh V. Formulation development, and evaluation of antidiabetic polyherbal tablet. Pharma Innov J 2014;3:1–3.

Nagar P, Singh K, Chauhan I, Madhu V, Yasir M, Khan A, et al. Orally disintegrating tablets: formulation, preparation, techniques, and evaluation. J Appl Pharm Sci 2011;4:35-45.

Tiwari OP, Sharma M. Formulation, and development of fast dissolving tablet of methanolic extract of some traditionally used medicinal plants for arthritis. Int J Appl Pharm Biol Res 2017;8:28–32.

Mishra US, Murthy PN, Pasa G, Mishra D. Formulation development and evaluation of herbal tablet containing methanolic extract of Butea frondosa. Int J Inst Pharm Life Sci 2011;1:1–15.

Christianah I, Ekere K, Judith O, Olayemi O, Darlington O, et al. Phytopharmaceutical properties of herbal teas circulating in the Nigerian market. Afr J Pharm Pharmacol 2016;10:1007–13.

Shah RB, Tawakkul MA, Khan MA. Comparative evaluation of flow for pharmaceutical powders and granules. AAPS Pharm Sci Tech 2008;9:250–8.

Kagalkar AA, Nanjwade BK, Bagli RS. Development and evaluation of herbal fast dissolving tablets of Tectona grandis Linn. Int J Pha Res Rev 2014;3:6-14.

Monton C, Saingam W, Suksaeree J, Sakunpak A, Kraisintu K. Preformulation and physical properties study of fast disintegrating tablets from Thai traditional formula. Int J Pharm Pharm Sci 2014;6:431-4.

US department of health and human services food and drug administration center for drug evaluation and research. Guidance for industry: orally disintegrating tablets. New Hampshire eve: Division of drug information food and drug administration; 2008.

Hahm HA, Augsburger LL. Orally disintegrating tablets and related tablet formulations. In: Pharmaceutical Dosage Forms: Tablets. New York: Informa Healthcare; 2008. p. 293-312.

Disch L, Drewe J, Fricker G. Dissolution testing of herbal medicines: challenges and regulatory standards in Europe, the United States, Canada, and Asia. Disso Technol 2017:6-12.

Guidance for industry, ICH topic Q1A (R2) stability testing of new drug substances and products. Eur Med Agency (EMEA) 2003;CPMP/ICH/2736/99.

Bunaciu AA, Aboul-Enein HY, Fleschin S. Recent applications of fourier transform infrared spectrophotometry in herbal medicine analysis. Appl Spectro Rev 2011;46:251-60.

Kumar PP, Pillai S, Michael M, Kavya K, Kumar P, Iqbal SS, et al. Fourier transform infrared (FT-IR) spectral studies of a novel polyherbal formulation of anti-obesity drug. J Med Sci-Tech 2015;4:55–7.

Patra A, Jha S, Murthy PN, Sampathy S, Kumar T. Preliminary phytochemical screening and antipyretic activity of leaf and root of Hygrophila spinosa T. anders. Pharmacol Online 2009;1:449–53.

Kala M, Kumar T, Singh HK. Effect of bacosides enriched standardized extract of Bacopa monniera (BESEB-CDRI-08) on lipid profile and blood pressure of postmenopausal women: a pilot study. Pharma Innov J 2015;4:91–5.

Maurya H, Kumar T. Formulation, characterization and pharmacological evaluation of anti-inflammatory polyphyto matrix tablet as a novel drug delivery system. Indian J Pharm Biol Res 2016;4:50–7.

Gupta S, Gahlot K. Formulation and evaluation of herbal antidemential tablets. Asian J Pharm Clin Res 2012;5:148–53.



How to Cite

Maurya, H., & Kumar, T. (2019). FORMULATION, STANDARDIZATION, AND EVALUATION OF POLYHERBAL DISPERSIBLE TABLET. International Journal of Applied Pharmaceutics, 11(1), 158–167.



Original Article(s)