A REVIEW ON POLOXAMER AND HYDROXY PROPYL METHYL CELLULOSE COMBINATION AS THERMORESPONSIVE POLYMERS IN NOVEL OPHTHALMIC IN SITU GEL FORMULATION AND THEIR CHARACTERIZATION

INSAN SUNAN KURNIAWANSYAH; TAOFIK RUSDIANA; IYAN SOPYAN; ANAS SUBARNAS

doi:10.22159/ijap.2021v13i1.39697

Authors

INSAN SUNAN KURNIAWANSYAH Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, West Java, Indonesia
TAOFIK RUSDIANA Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, West Java, Indonesia
IYAN SOPYAN PUSDI Drug Delivery and Drug Disposition Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, West Java, Indonesia
ANAS SUBARNAS Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, UniversitasPadjadjaran, Sumedang, West Java, Indonesia

DOI:

https://doi.org/10.22159/ijap.2021v13i1.39697

Keywords:

In situ gel, Ocular disease, Bioavailability, Poloxamer 407, HPMC, Ciprofloxacin, Fluconazole, Ofloxacin

Abstract

Poor bioavailability is one of the most significant problems in the delivery of the ocular drug system. Ophthalmic ointments, solutions and suspensions are the most frequently used dosage forms to treat ocular disease, and their effectiveness as a drug are compromised by several limitations that lead to poor ocular bioavailability. In situ gel is one of the most promising strategy and solutions to improve the ocular bioavailability of drugs. The purpose of this review is to discuss the formulation and characterization of in situ gel. This review is written based on the data or information obtained by using several search engines and several scientific journals, focused on Poloxamer 407 and Hydroxy Propyl Methyl Cellulose (HPMC) bases combination.

Active ingredients to treat ocular disease such as Ciprofloxacin, Fluconazole and Ofloxacin can be formulated with the combination of Poloxamer 407 as polymer gelling agent and HPMC as viscosity enhancer to produce good quality in situ gel dosage forms. The in situ gel dosage forms can be a promising alternate solution for the ophthalmic delivery system.

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