EVALUATION OF ANTI-GLYCATION EFFECT AND SAFETY OF SERUM ANTI-AGING FORMULATION CONTAINING GOLD NANOPARTICLES (AUNP) USING SIDAGURI EXTRACT (SIDA RHOMBIFOLIA)

DYAH AYUWATI WALUYO; SUTRIYO

doi:10.22159/ijap.2022v14i1.40417

Authors

DYAH AYUWATI WALUYO Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, West Java, Indonesia
SUTRIYO Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, West Java, Indonesia

DOI:

https://doi.org/10.22159/ijap.2022v14i1.40417

Keywords:

Gold nanoparticle, Sidaguri extract, Glycation, HET-CAM, Safety

Abstract

Objective: The purpose of this study is to determine the anti-aging properties and safety of serum containing gold nanoparticles (AuNP) using Sidaguri extract (Sida rhombifolia) through their anti-glycation effect.

Methods: The anti-aging effect of serum was performed in vitro by measuring advance glycation end products (AGEs) formed during incubation using a Microplate reader, and safety of serum was performed using hen’s egg chorioallantoic membrane (HET-CAM) method using White Leghorn egg.

Results: The study showed that serum formulation had an anti-glycation effect with inhibition percentages are 68.20±6.86% and 74.83%±19.91% for a serum containing 10% and 20% gold nanoparticles and little to no irritation potency for both serum formulations with RI value 0.0 and 0.0, respectively.

Conclusion: Due to both their anti-glycation effect and irritation behavior, serum formulation containing gold nanoparticle synthesized using Sidaguri extracts could be utilized as anti-aging cosmetics in the future.

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