FORMULATION, CHARACTERIZATION AND STABILITY STUDY OF FAST DISSOLVING THIN FILM CONTAINING ASTAXANTHIN NANOEMULSION USING HYDROXYPROPYLMETHYL CELLULOSE POLYMER
DOI:
https://doi.org/10.22159/ijap.2021.v13s3.03Keywords:
Astaxanthin, Nanoemulsion, Thin film, Solvent casting methodAbstract
Objective: The present study was conducted to formulate and characterize the thin film containing astaxanthin nanoemulsion (TF-ASN) using Hydroxypropylmethyl Cellulose (HPMC) polymer as a film matrix system. The stability studies in different storage conditions were also performed.
Methods: Astaxanthin nanoemulsion (As-NE) was prepared by using self-nanoemulsifying method, followed by incorporation into the HPMC matrix system by solvent casting method to forming TF-ASN. Evaluation of TF-ASN was performed by physical and mechanical characterizations. Stability study was carried out in both of accelerated (temperature of 40±2 °C/75±5% RH) and non-accelerated (at ambient temperature) conditions. Assay of astaxanthin in individual TF-ASN was determined compared to pure astaxanthin.
Results: TF-ASN had good physical and mechanical characteristics that suitable for intraoral administration.
Conclusion: For the study of stability under different storage conditions, it was proven that nanoemulsion form was packed in a HPMC matrix could enhance the stability of the astaxanthin.
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References
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2. Paiva SA, Russell RM. ?-carotene and other carotenoids as antioxidants. J Am Coll Nutr 1999;18:426-33.
3. Kurashige M, Okimasu E, Inoue M, Utsumi K. Inhibition of oxidation injury of biological membranes by astaxanthin. Physiol Chem Phys Med NMR 1990;22:27-38.
4. Clark RM, Yao L, She L, Furr HC. A comparison of lycopene and astaxanthin absorption from corn oil and olive oil emulsions. Lipids 2000;35:803-6.
5. Zaripheh S, Erdman Jr JW. Factors that influence the bioavailability of xanthophylls. J Nutr 2002;132:531S-534S.
6. Parker RS. Absorption, metabolism, and transport of carotenoids. FASEB J 1996;10:542-51.
7. Choi HD, Kang HE, Yang SH, Lee MG, Shin WG. Pharmacokinetics and first-pass metabolism of astaxanthin in rats. Br J Nutr 2011;105:220-7.
8. Dixit RP, Puthli SP. Oral strip technology: overview and future potential. J Controlled Release 2009;139:94-107.
9. Mitra AK, Alur HH, Johnston P. Protein-buccal absorption, Encyclopedia of Pharmaceutical Technology; 2002. p. 2081-93.
10. Garsuch V. PhD Thesis. Preparation and characterization of fast-dissolving oral films for pediatric use. Department of Pharmaceutical Technology and Biopharmacy, Faculty of Mathematics and Natural Sciences, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; 2009.
11. Chen MC, Sonaje K, Chen KJ, Sung HW. A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery. Biomaterials 2011;32:9826-38.
12. Nurdianti L, Rusdiana T, Sopyan I, Putriana NA, Aiman HR, Fajria TR. Characteristics comparison of intraoral thin film containing astaxanthin nanoemulsion using sodium alginate and gelatin polymers. Turk J Pharm Sci 2020. DOI:10.4274/tjps.galenos.2020.25483
13. Nurdianti L, Aryani R, Indra I. Formulation and characterization SNE (self nanoemulsion) of astaxanthin of haematococcus pluvialis as natural super antioxidant. JSFK 2017;4:36-42.
14. Bala R, Pawar P, Khanna S, Arora S. Orally dissolving strips: a new approach to oral drug delivery system. Int J Pharm Investig 2013;3:67.
15. Guideline, IHT. Stability testing of new drug substances and products. Q1A (R2) Curr Step 2003;4:1-24.
16. Krstic M, Medarevic D, Duris J, Ibric S. Self-nanoemulsifying drug delivery systems (SNEDDS) and self-microemulsifying drug delivery systems (SMEDDS) as lipid nanocarriers for improving dissolution rate and bioavailability of poorly soluble drugs. Lipid nanocarriers for drug targeting. William Andrew Publishing; 2018. p. 473-508.
17. Date AA, Desai N, Dixit R, Nagarsenker M. Self-nanoemulsifying drug delivery systems: formulation insights, applications and advances. Nanomedicine 2010;5:1595-616.
18. Irfan M, Rabel S, Bukhtar Q, Qadir MI, Jabeen F, Khan A. Orally disintegrating films: a modern expansion in drug delivery system. Saudi Pharm J 2016;24:537-46.
19. Karki S, Kim H, Na SJ, Shin D, Jo K, Lee J. Thin films as an emerging platform for drug delivery. Asian J Pharm Sci 2016;11:559-74.
20. Pathare YS, Hastak VS, Bajaj AN. Polymers used for fast disintegrating oral films: a review. Polymer 2013;14:169-78.
21. Joshua JM, Hari R, Jyothish FK, Surendran SA. Fast dissolving oral thin films: an effective dosage form for quick releases. Drugs 2016;11:12.
22. Siddiqui MN, Garg G, Sharma PK. A short review on “A novel approach in oral fast dissolving drug delivery system and their patents”. Adv Biol Res 2011;5:291-303.
23. Mandeep K, Rana AC, Nimrata S. Fast dissolving films: an innovative drug delivery system. Int J Pharm Res Allied Sci 2013;2:14-24.
24. Anderson MJ, Whitcomb PJ. Optimizing formulation performance with desirability functions. InQuebec Metallurgical Conference; 1993.
25. Nair AB, Kumria R, Harsha S, Attimarad M, Al-Dhubiab BE, Alhaider IA. In vitro techniques to evaluate buccal films. J Controlled Release 2013;166:10-21.
26. Alanazi FK, Rahman AA, Mahrous GM, Alsarra IA. Formulation and physicochemical characterisation of buccoadhesive films containing ketorolac. J Drug Delivery Sci Tech 2007;17:183-92.
27. Preis M, Knop K, Breitkreutz J. Mechanical strength test for orodispersible and buccal films. Int J Pharm 2014;461:22-9.
28. Heng PW, Chan LW, Ong KT. Influence of storage conditions and type of plasticizers on ethylcellulose and acrylate films from aqueous dispersions. J Pharm Pharm Sci 2003;6:334-44.
29. Morales JO, McConville JT. Manufacture and characterization of mucoadhesive buccal films. Eur J Pharm Biopharm 2011;77:187-99.
30. Liew KB, Tan YT, Peh KK. Effect of polymer, plasticizer and filler on orally disintegrating film. Drug Dev Ind Pharm 2014;40:110-9.
31. Ambati RR, Phang SM, Ravi S, Aswathanarayana RG. Astaxanthin: sources, extraction, stability, biological activities and its commercial applications—a review. Marine Drugs 2014;12:128-52.
32. Higuera Ciapara I, Felix Valenzuela L, Goycoolea FM, Arguelles Monal W. Microencapsulation of astaxanthin in a chitosan matrix. Carbohydr Polym 2004;56:41–45.
33. Rao SV, Shao J. Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of protein drugs: I. Formulation development. Int J Pharm 2008;362:2-9.
Published
10-03-2021
How to Cite
NURDIANTI, L., SOPYAN, I., & RUSDIANA, T. (2021). FORMULATION, CHARACTERIZATION AND STABILITY STUDY OF FAST DISSOLVING THIN FILM CONTAINING ASTAXANTHIN NANOEMULSION USING HYDROXYPROPYLMETHYL CELLULOSE POLYMER. International Journal of Applied Pharmaceutics, 13(3), 17–22. https://doi.org/10.22159/ijap.2021.v13s3.03
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