FORMULATION AND CHARACTERIZATION OF FLOATING TABLET DOSAGE FORM OF DUAL DELIVERY OF DRUG CURCUMIN AND BERBERINE HYDROCHLORIDE USING SIMULTANEOUS ESTIMATION BY UV SPECTROSCOPY

KOLLOL KUMAR MAJUMDER; MANISH KUMAR; RAKESH PAHWA; AVNEET KAUR LAMBA; RAVI SHANKAR; ABHISHEK TIWARI; VARSHA TIWARI; RISHABH

doi:10.22159/ijap.2021v13i5.42098

Authors

KOLLOL KUMAR MAJUMDER M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana 133207
MANISH KUMAR M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana 133207
RAKESH PAHWA Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra 136119, Haryana, India
AVNEET KAUR LAMBA Department of Pharmaceutical Sciences, Gurugram University, Gurugram 122003
RAVI SHANKAR Department of Pharmacy, Sagar Institute of Technology and Management, Barabanki, Uttar Pradesh, 225001
ABHISHEK TIWARI Department of Pharmacy, Devsthali Vidyapeeth College of Pharmacy, Lalpur, Rudrapur (U. S. Nagar), Uttrakhand, India
VARSHA TIWARI Department of Pharmacy, Devsthali Vidyapeeth College of Pharmacy, Lalpur, Rudrapur (U. S. Nagar), Uttrakhand, India
RISHABH M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana 133207

DOI:

https://doi.org/10.22159/ijap.2021v13i5.42098

Keywords:

Curcumin, Berberine hydrochloride, HPMC K-100M, HPMC K-15M, Floating, Sodium bi carbonate, In Vitro BuoyancyIn Vitro Buoyancy

Abstract

Objective: The present study was aimed to develop a combinational floating tablet of curcumin and berberine HCl utilizing synthetic polymers synthetic HPMC K-15M and evaluate its various characteristics.

Methods: The formulations were developed by the process of wet granulation and evaluated for drug content, content uniformity, floating lag time, total floating time, in vitro buoyancy studies, and in vitro drug release profile. A simultaneous estimation method for curcumin and berberine was developed using U. V spectroscopy.

Results: The results clearly indicated that the tablets produced were having acceptable physical parameters. The absence of any drug/polymer/excipient interactions was confirmed using infrared spectroscopy. It was found that the drug content of was in between 96.22 to 99.45 % in all the formulations. Because of their low densities, in vitro floatability tests showed that most of the tablets floated for more than 8 h. The in vitro release studies confirmed the sustained release of more than 80 percent of drug contained within a period of 8 h. In vitro buoyancy was good in all three batches (F1-F3). The overall floating time for the F2 formulation was 24 h. After one month of storage at 40 °C and 75 percent RH, the F2 formulation showed no noticeable change in physical as well as pharmaceutical performance characteristics.

Conclusion: Floating tablets of curcumin and berberine was successfully developed and had passed on various pharmaceutical parameters.

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