THERAPEUTIC AND PHARMACOLOGICAL EFFICACY OF PLANT BOERHAAVIA DIFFUSA–A REVIEW

Authors

  • VIDHYA REKHA U. Department of Public Health Dentistry, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai 600100, India
  • BHUMINATHAN S. Department of Prosthodontics, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai 600100, India
  • M. REKHA Department of Oral and Maxillofacial Surgery, RVS Dental College and Hospital, Kannampalayam, Sulur, Coimbatore 641402, India
  • NANDHINI M.S. Department of Microbiology, Sree Balaji Dental College and Hospital, Pallikaranai, Chrompet, Chennai 600044, India
  • RAVI SHANKAR Department of Public Health Dentistry, Rajas Dental College and Hospital, Kavalkinaru, Tirunelveli District, Tamilnadu, India

DOI:

https://doi.org/10.22159/ijap.2022.v14ti.41

Keywords:

Medicinal plant, Boerhaavia diffusa, Therapeutic effects

Abstract

Boerhavia diffusa (BD) is a herb of rasayana type, according to ayurvedic statements. It is considered to offer anti-aging, anti-disease, and life-strengthening qualities. Diffusa Boerhaavia Linn. Contains a wide variety of therapeutic qualities that have been demonstrated to be beneficial in the treatment of hyperglycemia, inflammation, anxiety, hepatotoxicity, jaundice, and heart problems. Here, we focus on the chemical composition and ethnomedicinal uses of B. diffusa that extend back to ancient times, as well as their future development.

B. diffusa's exceptional antioxidant, hepatoprotective, antibacterial, anti-diabetic, and anticarcinogenic capabilities have drawn pioneers in science and medicine. Additionally, this herb possesses medicinal properties, which is a result of the presence of polyphenols and flavanoids, creates it more vital for clinicians and scientists to exploit in order to obtain a better understanding of its biological and pharmacological capabilities.

Downloads

Download data is not yet available.

References

Govindarajan R, Vijayakumar M, Pushpangadan P. Antioxidant approach to disease management and the role of ’Rasayana’ herbs of Ayurveda. J Ethnopharmacol. 2005 Jun 3;99(2):165-78. doi: 10.1016/j.jep.2005.02.035. PMID 15894123.

Milic N. Biological and phytochemical studies on ’Boerhavia diffusa’. J Ethnopharmacol. 2008;74:113-23.

Prachi ChauhanN, Kumar D, Kasana MS. Medicinal plants of muzaffaranagar district used in the treatment of urinary tract and kidney stones. Indian J Tradit Know. 2009;8(2):191-5.

Ragi TP, Shibu BS. In vitro propagation of boerhavia diffusa L. (Nyctaginaceae) via nodal and leaf explants. As Pac J Mol Biol Biotechnol. 2014;22(3):219-23.

Victor AD, Mohanasundaram S, Prasad M. Analysis of hydroethanolic extract of Senna alata (L.) to screen bioactive compounds with inhibitory activity on lipid peroxidation, in vitro antibacterial and antidiabetic efficacy. Int J Pharm Sci. 2016;6(1):1360-6.

Sandhu PS, Singh B, Gupta V, Bansal P, Kumar D. Potential herbs used in ocular diseases. J Pharm Sci Res. 2011;3(4):1127-40.

Rameshkumar S, Ramakritinan CM. Floristic survey of traditional herbal medicinal plants for treatments of various diseases from coastal diversity in Pudhukkottai District, Tamil Nadu, India. J Coast Life Med. 2013;1(3):225-32.

Mohanasundaram S, Rangarajan N, Sampath V, Porkodi K, Pennarasi M. GC-MS and HPLC analysis of antiglycogenolytic and glycogenic compounds in kaempferol 3–O–gentiobioside containing senna alata L leaves in experimental rats. Transl Metab Syndr Res. 2021;4:10-7. doi: 10.1016/ j.tmsr.2021.07.001.

Kamlekar S, Kota K, Tahashildar J, Erumalla VNR, Chenna S. In vitro antimicrobial potential of boerhavia diffusa L. Root extract on pathogenic organisms. World J Pharm Res. 2014;3:442-50.

Apu AS, Liza MS, Jamaluddin AT, Howlader MA, Saha RK, Rizwan F. Phytochemical screening and in vitro bioactivities of the extracts of aerial part of Boerhavia diffusa Linn. Asian Pac J Trop Biomed. 2012 Sep;2(9):673-8. doi: 10.1016/S2221-1691(12)60208-1, PMID 23569993, PMCID PMC3609381.

Mohanasundaram S, Rangarajan N, Sampath V, Porkodi K, Prakash MVD, Monicka N. GC-MS identification of anti-inflammatory and anticancer metabolites in edible milky white mushroom (Calocybe indica) against human breast cancer (MCF-7) cells. Res J Pharm Technol. 2021;14(8):4300-6.

Madhuri S, Kalasker V. Evaluation of diuretic activity of aqueous extract of Boerhavia diffusa roots in Rats. Int J Pharm Biol Sci. 2013;4(4):843-8.

Pareta SK, Patra KC, Mazumder PM, Sasmal D. Boerhavia diffusa Linn. Aqueous extract as curative agent in ethyl- glycol i¬nduced urolithiasis. Pharmacologyonline. 2010;3:112-20.

Khan MS, Khan A, Iqbal J. Effect of dietary tocotrienols on infection and inflammation-induced lipoprotein oxidation in hamsters. Int J Pharm Pharm Sci. 2011;3(3):277-84.

Mohanasundaram S, Victor AD, Prasad M, Magesh R, Sivakumar K, Subathra M. Pharmacological analysis of hydroethanolic extract of Senna alata (L.) for in vitro free radical scavenging and cytotoxic activities against Hep G2 cancer cell line. Pak J Pharm Sci. 2019;32(3):931-4.

Mungantiwar AA, Nair AM, Kamal KK, Saraf MN. Adaptogenic activity of aqueous extract of the roots of Boerhaavia diffusa linn. Indian Drugs. 1997;34(4):184-9.

Sumanth M, Mustafa SS. Antistress, adoptogenic activity of sida cordifolia roots in mice. Indian J Pharm Sci. 2009 May;71(3):323-4. doi: 10.4103/0250-474X.56027, PMID 20490305, PMCID PMC2865797.

Karthikeyan V, Sivakumar K, Aishwarya G, MohanaSundaram S. Studies on larvicidal activity of leucas aspera, vitex negundo and eucalyptus against culex quinquefasciatus collected from coovum river of Chennai, India. Asian J Pharm Sci Clin Res. 2012;5(3):1-4.

Mehrotra S, Mishra KP, Maurya R, Srimal RC, Singh VK. Immunomodulation by ethanolic extract of Boerhaavia diffusa roots. Int Immunopharmacol. 2002 Jun;2(7):987-96. doi: 10.1016/s1567-5769(02)00031-0, PMID 12188040.

Narendhiran S, Mohanasundaram S, Arun J, Saravanan L, Catherine L, Subathra M. Comparative study in larvicidal efficacy of medicinal plant extracts against Culex quinquefasciatus. Int J Res Plant Sci. 2014;4(1):22-5.

Li J, Li H, Kadota S, Namba T, Miyahara T, Khan UG. Effects on cultured neonatal mouse calvaria of the flavonoids isolated from Boerhaavia repens. J Nat Prod. 1996 Nov;59(11):1015-8. doi: 10.1021/np960453a, PMID 8946741.

Srivastava K, Dasgupta PK. NAD-dependent-15-hydroxy-prostagtandin dehydrogenase activity in the endometrium of IUD-and Boerhaavia diffusa Linn. treated female rhesus monkeys. Malaysian J Public Heal. 1986;4:1-5.

Victor AD, Prasad M, Mohanasundaram S. Biological active compounds with various medicinal values of Strychnos nux-vomica–a pharmacological summary. J Glob Trends Pharm Sci. 2016;7(1):3044-7.

Ahmed Belkacem A, Macalou S, Borrelli F, Capasso R, Fattorusso E, Taglialatela Scafati O. Nonprenylated rotenoids, a new class of potent breast cancer resistance protein inhibitors. J Med Chem. 2007 Apr 19;50(8):1933-8. doi: 10.1021/jm061450q. PMID 17341062.

Srivastava R, Saluja D, Dwarakanath BS, Chopra M. Inhibition of human cervical cancer cell growth by ethanolic extract of boerhaavia diffusa Linn. (Punarnava) root. Evid Based Complement Alternat Med. 2011;2011:427031. doi: 10.1093/ecam/nep223. PMID 21869896, PMCID PMC3159392.

Bharathi P, Elavarasi N, Mohanasundaram S. Studies on rate of biodegradation of vegetable oil (Cocunut oil) by using pseudomonas sp. Int J Environ Biol. 2012;2(2):12-9.

Leyon PV, Lini CC, Kuttan G. Inhibitory effect of Boerhaavia diffusa on experimental metastasis by B16F10 melanoma in C57BL/6 mice. Life Sci. 2005 Feb 4;76(12):1339-49. doi: 10.1016/j.lfs.2004.06.031. PMID 15670614.

Manu KA, Kuttan G. Effect of punarnavine, an alkaloid from boerhaavia diffusa, on cell-mediated immune responses and TIMP-1 in B16F-10 metastatic melanoma-bearing mice. Immunopharmacol Immunotoxicol. 2007;29(3-4):569-86. doi: 10.1080/08923970701692676, PMID 18075866.

Rangarajan N, Sangeetha R, Mohanasundaram S, Sampath, Porkodi K, Dass Prakash MV. Additive inhibitory effect of the peels of Citrus limon and Citrus sinensis against amylase and glucosidase activity. IJRPS 2020;11(4):6876-80. doi: 10.26452/ijrps.v11i4.3661.

Manu KA, Leyon PV, Kuttan G. Studies on the protective effects of Boerhaavia diffusa L. against gamma radiation-induced damage in mice. Integr Cancer Ther. 2007 Dec;6(4):381-8. doi: 10.1177/1534735407309743, PMID 18048886.

Chude MA, Orisakwe OE, Afonne OJ, Gamaniel KS, Vongtau OH, Obi E. Hypoglycaemic effect of the aqueous extract of Boerhavia diffusa leaves. Indian J Pharmacol. 2001; 33(3):215-6.

Pari L, Amarnath Satheesh M. Antidiabetic effect of boerhavia diffusa: effect on serum and tissue lipids in experimental diabetes. J Med Food. 2004;7(4):472-6. doi: 10.1089/jmf.2004.7.472, PMID 15671692.

Rangarajan N, Sampath, Dass Prakash M, Mohanasundaram S. UV Spectrophotometry and FTIR analysis of phenolic compounds with antioxidant potentials in glycyrrhiza glabra and zingiber officinale. IJRPS 2021;12(1):877-83. doi: 10.26452/ijrps.v12i1.4215.

Gulati R, Agarwal S, Agarwal SS. Hepatoprotective activity of Boerhaavia diffusa linn. Against country-made liquor induced hepatotoxicity in albino rats fed on controlled calorie diet. Indian J Pharmacol. 1991;23(4):264-7.

Asadulla S. Anti-inflammatory activities of Boerhavia diffusa roots in Albino rats. Arch Pharm Res. 2010;2:267-70.

Olaleye MT, Akinmoladun AC, Ogunboye AA, Akindahunsi AA. Antioxidant activity and hepatoprotective property of leaf extracts of Boerhaavia diffusa Linn against acetaminophen-induced liver damage in rats. Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2200-5. doi: 10.1016/j.fct.2010.05.047. PMID 20553784.

Wang Q, Sivakumar K, Mohanasundaram S. Impacts of extrusion processing on food nutritional components. Int J Syst Assur Eng Manag. 2022;13(S1):364-74. doi: 10.1007/s13198-021-01422-2.

Singh S, Awasthi LP, Verma HN. Prevention and control of yellow mosaic disease of mung bean by application of aqueous root extract of Boerhaavia diffusa. Ind Phytopathol. 2004;57(3):303-7.

Agrawal A, Srivastava S, Srivastava JN, Srivastava MM. Inhibitory effect of the plant Boerhavia diffusa l. Against the dermatophytic fungus Microsporum fulvum. J Environ Biol. 2004 Jul;25(3):307-11. PMID 15847339.

Sivakumar S, Mohanasundaram S, Rangarajan N, Sampath V, Velayutham Dass Prakash MV. In silico prediction of interactions and molecular dynamics simulation analysis of Mpro of severe acute respiratory syndrome caused by novel coronavirus 2 with the FDA-approved nonprotein antiviral drugs. J Appl Pharm Sci. 2022;12(05):104-19. doi: 10.7324/JAPS.2022.120508.

Mungantiwar AA, Nair AM, Kamal KK, Saraf MN. Adoptogenic activity of aqueous extract of the roots of Boerhaavia diffusa Linn. Ind Drugs. 1997;34:184-9.

Adenubi OT, Raji Y, Awe EO, Makinde JM. The effect of the aqueous extract of the leaves of Boerhaavia diffusa on semen and testicular morphology of male wistar rats. Sci World J. 2010;5(2):1-6.

Published

28-07-2022

How to Cite

U., V. R., S., B., REKHA, M., M.S., N., & SHANKAR, R. (2022). THERAPEUTIC AND PHARMACOLOGICAL EFFICACY OF PLANT BOERHAAVIA DIFFUSA–A REVIEW. International Journal of Applied Pharmaceutics, 14, 58–62. https://doi.org/10.22159/ijap.2022.v14ti.41

Issue

Section

Review Article(s)