• IIN HELDAYANI Oral Medicine Specialist Program, Faculty of Dentistry, Padjadjaran University, Jl. Sekeloa Selatan no 1, Bandung, West Java, Indonesia 40132
  • INDAH SUASANI WAHYUNI Department of Oral Medicine, Faculty of Dentistry, Padjadjaran University, Jl. Sekeloa Selatan no 1, Bandung, West Java, Indonesia 40132




RAS, Natural-based product, Mucoadhesive


The objective was to describe and recommend the most effective combination of Natural-Based Product (NBP) and mucoadhesive for Recurrent Aphthous Stomatitis (RAS) treatment. This systematic review writing was based on PRISMA guidelines. The articles published in the last 10 y were selected using PubMed and Google Scholar database carried out during May 2021. The keywords were: natural-based product, mucoadhesive, and Recurrent Aphthous Stomatitis. The risk of bias was assessed using the Oxford Quality Scoring System. Six articles of Randomized Controlled Trial were selected. The NBP were: Aloe vera, Myrrh, Curcuma longa, propolis, ginger, Punica granatum flower, and sesame oil. The drug’s formulation was: gel, film, and spray. The mucoadhesive polymers as vehicles were Hydroxy Propyl Ethyl Cellulose (HPEC), Hydroxy Propyl Methylcellulose (HPMC), Benzocaine, Tragacanth Gum, Carbomer 934, Sodium CMC (carboxymethyl cellulose), and chitosan. Curcuma longa 10 mg/g with HPMC was the most effective to relieve pain, while Punica granatum flower extract with Carbomer 934 and Sodium CMC was the most effective to reduce the ulcer size in RAS. Both of the formulations were in gel form.


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How to Cite

HELDAYANI, I., & WAHYUNI, I. S. (2021). EFFECTIVENESS OF THE NATURAL-BASED PRODUCTS AND MUCOADHESIVE FOR RECURRENT APHTHOUS STOMATITIS THERAPY: A SYSTEMATIC REVIEW. International Journal of Applied Pharmaceutics, 13(4), 7–13. https://doi.org/10.22159/ijap.2021.v13s4.43810



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