SINGLE-NUCLEOTIDE POLYMORPHISM OF TNFSF4 (RS2205960) OF SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS IN BANDUNG, INDONESIA

ANGELA APRILIA KARYADI; ERICA WILLY; GABRIEL BAGUS KENNARDI; MUHAMMAD SYAWAL PRATAMA; DESI RESKI FAJAR; LANIYATI HAMIJOYO; RIEZKI AMALIA; MELISA INTAN BARLIANA

doi:10.22159/ijap.2021.v13s4.43827

Authors

ANGELA APRILIA KARYADI Department Biological Pharmacy, Faculty of Pharmacy, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, 45363, Indonesia
ERICA WILLY Department Biological Pharmacy, Faculty of Pharmacy, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, 45363, Indonesia
GABRIEL BAGUS KENNARDI Immunology Study Center, Faculty of Medicine, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, 45363, Indonesia
MUHAMMAD SYAWAL PRATAMA Department of Pharmacology and Clinical Pharmacy, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, 45363, Indonesia
DESI RESKI FAJAR Department Biological Pharmacy, Faculty of Pharmacy, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, 45363, Indonesia
LANIYATI HAMIJOYO Immunology Study Center, Faculty of Medicine, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, 45363, Indonesia, Department of Internal Medicine Faculty of Medicine, Padjadjaran University, Hasan Sadikin Hospital, Jl. Pasteur 38 Bandung, 40161, Indonesia
RIEZKI AMALIA Department of Pharmacology and Clinical Pharmacy, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, 45363, Indonesia, Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, 45363, Indonesia
MELISA INTAN BARLIANA Department Biological Pharmacy, Faculty of Pharmacy, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, 45363, Indonesia, Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, 45363, Indonesia

DOI:

https://doi.org/10.22159/ijap.2021.v13s4.43827

Keywords:

Bandung, Single-nucleotide polymorphism, RS2205960, Systemic lupus erythematosus, TNFSF4

Abstract

Objective: This study aimed to determine the genotype distribution of the TNFSF4 (Tumor Necrosis Factor Superfamily 4) gene rs2205960 in Systemic Lupus Erythematosus (SLE) patients in Bandung, West Java, Indonesia.

Methods: This was a cross-sectional study; 84 genomic DNA samples were amplified, electrophoresed, then analyzed by DNA sequencing.

Results: The genotype distribution of the TNFSF4 gene rs2205960 in SLE patients showed that from 84 DNA samples, 55 patients are GG (65.48%), 25 patients are GT (29.76%), and 4 patients are TT (4.76%).

Conclusion: Results indicate that SLE patients in Bandung have a genotype distribution of the TNFSF4 rs2205960 gene that fulfills the Hardy-Weinberg equilibrium.

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