A REVIEW OF ADVANCED NANOTECHNOLOGIES AND DRUG DELIVERY SYSTEMS OF SALINOMYCIN AND THEIR ROLE IN TRIPLE-NEGATIVE BREAST CANCER

GOKUL RAJ R.; PREETHI S.; AMIT B. PATIL; VIKAS JAIN; RAMKISHAN AJMEER

doi:10.22159/ijap.2022v14i4.44237

Authors

GOKUL RAJ R. Department of Pharmaceutics, JSS College of Pharmacy, JSSAHER, SS Nagara, Mysuru 570015, Karnataka, India
PREETHI S. Department of Pharmaceutics, JSS College of Pharmacy, JSSAHER, SS Nagara, Mysuru 570015, Karnataka, India
AMIT B. PATIL Department of Pharmaceutics, JSS College of Pharmacy, JSSAHER, SS Nagara, Mysuru 570015, Karnataka, India
VIKAS JAIN Department of Pharmaceutics, JSS College of Pharmacy, JSSAHER, SS Nagara, Mysuru 570015, Karnataka, India
RAMKISHAN AJMEER Department of Pharmaceutics, JSS College of Pharmacy, JSSAHER, SS Nagara, Mysuru 570015, Karnataka, India

DOI:

https://doi.org/10.22159/ijap.2022v14i4.44237

Keywords:

Salinomycin, Breast cancer, Nanotechnology, Drug delivery system

Abstract

Cancer cells spread to other tissues and organs when they divide incorrectly. Breast cancer (BC) is the main cause of cancer-related mortality globally. Some recent studies on cancer stem cells (CSCs), drug resistance, tumor recurrence and metastasis, and the significance of CD44⁺in targeted treatment for breast cancer are covered. Breast cancer stem cells (BCSCs) and bulk BC cells must be eliminated for the disease to be eliminated. Researchers have shown that Streptomyces Albus-derived monocarboxylic polyether antibiotic salinomycin kills human cancer stem cells (CSCs) and prevents the spread and growth of breast cancer cells. Several drug and apoptosis resistance mechanisms may also trigger apoptosis in breast cancer cells when salinomycin is used in combination with the treatment. Apoptosis-resistant cancer cells and cancer stem cells are both susceptible to the anticancer drug salinomycin. Salinomycin may be able to inhibit CSCs, as well as the source and structure modification of salinomycin analog exhibit potent anticancer activity, the effect of salinomycin on chemotherapeutic-resistant CSCs, and the various mechanisms by which salinomycin inhibits cancer stem cells in this study. Method and delivery technique for salinomycin Nano formulation in triple-negative breast cancer and also contains pharmacokinetics and toxicity of salinomycin. Salinomycin-based drug delivery system is the subject of the patent information. Tumor genesis, development, and invasion are all aided by salinomycin. It's possible to boost the effectiveness of cancer therapy by focusing on cancer stem cells (CSCs).

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