COMPARATIVE STUDY OF SEMI-SOLID BASES OF NAPROXEN: PHARMACEUTICAL TECHNOLOGY ASPECTS

G. SRIVIDYA; R.A.M. JAINAF NACHIYA; DOAA EBRAHIM; AIDA M. EL-SAGHEER; SAMINATHAN KAYAROHANAM; ASHOK KUMAR JANAKIRAMAN; JIYAUDDIN KHAN; JAMAL MOIDEEN MUTHU MOHAMED

doi:10.22159/ijap.2022.v14ti.38

Authors

G. SRIVIDYA SVS College of Pharmaceutical Sciences, Bheemaram, Warangal, Telungana 506015, India
R.A.M. JAINAF NACHIYA Crescent School of Pharmacy, BS Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai 600048, India
DOAA EBRAHIM Department of Respiratory Care, College of Applied Medical Sciences in Jubail, Imam Abdulrahman Bin Faisal University, KSA
AIDA M. EL-SAGHEER Department of Neuroscience, College of Applied Medical Sciences in Jubail, Imam Abdulrahman Bin Faisal University, KSA
SAMINATHAN KAYAROHANAM Faculty of Bio-economy and Health Sciences, Geomatika University College Kuala Lumpur 54200, Malaysia
ASHOK KUMAR JANAKIRAMAN Faculty of Pharmaceutical Sciences, UCSI University, Cheras 56000, Kuala Lumpur, Malaysia
JIYAUDDIN KHAN Department of Pharmaceutics, School of Pharmacy, Management and Sciences University. Shah Alam, Selangor, Darul Ehsan, Malaysia
JAMAL MOIDEEN MUTHU MOHAMED College of Pharmacy, Shri Indra Ganesan Institute of Medical Science, Manikandam, Tiruchirapalli 620012, Tamil Nadu, India

DOI:

https://doi.org/10.22159/ijap.2022.v14ti.38

Keywords:

Semi-solid bases of NXN, Pharmaceutical technology aspects

Abstract

Objective: The main objectives of the present investigation work included that the preparation of a suitable naproxen semi-solid dosage form by using different types of semi-solid bases (gel bases, ointment bases) for topical application for the effective treatment of muscle aches.

Methods: Different types of semi-solid bases (gel bases and ointment bases) were successfully prepared by the incorporation method to know the effect of semi-solid bases on drug release from topical semi-solid formulations. In all formulations, the drug was added by the levigation method. An evaluation study of prepared formulations, includes physical appearance, spreadability, extrudability, pH was conducted according to official methods.

Results: Percent drug release of all formulations was conducted by taking diffusion cells with cellophane membrane and results showed that gel-based formulations showed more drug release than ointment-based formulations. Carbopol gel base (F1) showed more drug release (98.76 %), simple ointment base formulation (F8) showed least drug release (25.11%). From the stability studies reports at various temperature and humidity conditions it is evident that all formulations are stable for one month. In all the formulations, the drug content was observed at 95.75%.

Conclusion: Finally concluded that the NXN topical dosage forms can be prepared by using gel-type bases preferably than ointment bases to release more drug from formulations.

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