CALCIUM CARBONATE ISOLATION FROM EGGSHELL TO MEET PHARMACOPOEIAL STANDARDS AND ITS EFFECTIVENESS AS AN ANTACIDS

DADIH SUPRIADI; TIANA MILANDA; ANIS YOHANA C.; MUCTARIDI; MARLINE ABDASSAH

doi:10.22159/ijap.2023v15i5.48045

Authors

DADIH SUPRIADI Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia. Faculty of Pharmacy, Bhakti Kencana University, Bandung, Indonesia
TIANA MILANDA Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia
ANIS YOHANA C. Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia
MUCTARIDI Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia
MARLINE ABDASSAH Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia

DOI:

https://doi.org/10.22159/ijap.2023v15i5.48045

Keywords:

Eggshell, Calcium carbonate, Pharmaceutical grade, Antacid

Abstract

Objective: Calcium carbonate is widely used in the pharmaceutical field as excipients and therapeutic agents. Calcium carbonate can be obtained from limestone, chalk, marble and dolomite. Other alternative is from eggshell. Calcium carbonate source from eggshell has several advantages including higher calcium carbonate content, fewer contaminants metal limit, and more brittle. Therefore, in this study, calcium carbonate had been isolated from eggshells which was expected to meet the requirements of Indonesian Pharmacopoeia (sixth edition) and having activity as antacid.

Methods: Calcium carbonate were isolated from eggshells by mechanically and physically organic separation. The quality of calcium carbonate was examined according to the Indonesian Pharmacopoeia parameters including loss on drying; acid-insoluble substance, magnesium and alkali salt; limit of arsenic, lead, iron, mercury, heavy metal, and barium. Additional physicochemical characterization of calcium carbonate including particle size analyzer, FTIR and XRD were compared with those of commercial calcium carbonate.

Results: The results showed that the isolation produced 98.5±0.5 % of calcium carbonate. The calcium carbonate powder had an average size of 21±1.0 µm, while that of commercial was 8±1.3 µm. The resulted calcium carbonate revealed similar XRD patterns compared with that from commercial Calcium carbonate from the market. Based on database from FTIR instrument, the calcium carbonate sample had 99% similarity level compared with that from the reference. The sample of Calcium carbonate isolated from the eggshell (>mesh 100) had lower antacid activity (23.83 mEq) than that of commercial (24.56 mEq).

Conclusion: Calcium carbonate from eggshell fulfilled the requirements of Indonesian Pharmacopoeia.

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