BIOAVAILABILITY ENHANCEMENT STRATEGIES FOR RIVAROXABAN: A NOTEWORTHY REVIEW

Authors

  • ADAM A. AL-SHOUBKI Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, University of Derna, Derna, Libya. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Giza, Egypt https://orcid.org/0000-0002-6183-6309
  • MAHMOUD H. TEAIMA Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Giza, Egypt
  • REHAB ABDELMONEM Department of industrial Pharmacy, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology (MuST), 6th of October City, Giza, 12566, Egypt
  • MOHAMED A. EL-NABARAWI Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Giza, Egypt
  • SAMMAR FATHY ELHABAL Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Mokattam, Cairo 11571, Egypt

DOI:

https://doi.org/10.22159/ijap.2023v15i6.48839

Keywords:

Rivaroxaban, Bioavailability enhancement, Microspheres, Liposomes, Self-nanoemulsifying drug delivery system, Solid lipid nanoparticles, Cocrystals, Sustained release, Solid dispersion

Abstract

This review article discusses Rivaroxaban (RXB), an anticoagulant that has gained much attention due to its ability to prevent blood clots from forming in the body. However, one of the major challenges pharmaceutical companies face is the low water solubility of RXB, which can lead to difficulties in formulating the drug for oral administration and affect the drug's bioavailability. However, to the best of our knowledge, limited studies have explored enhancing the bioavailability of the RXB. Most of these studies have been purely academic and impractical for industrial use. Therefore, this review article aims to discuss successful studies that have increased the bioavailability of RXB. The goal is to inspire researchers to develop this new drug further. The article covers seven strategies for enhancing the bioavailability of RXB, including microspheres, liposomes, self-nano emulsifying drug delivery system, solid lipid nanoparticles, cocrystals, sustained release, and solid dispersion. The studies discussed in this review offer valuable insights into developing novel drug delivery systems that can help overcome the limitations of existing drugs.

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Published

07-11-2023

How to Cite

AL-SHOUBKI, A. A., H. TEAIMA, M., ABDELMONEM, R., EL-NABARAWI, M. A., & ELHABAL, S. F. (2023). BIOAVAILABILITY ENHANCEMENT STRATEGIES FOR RIVAROXABAN: A NOTEWORTHY REVIEW. International Journal of Applied Pharmaceutics, 15(6), 33–37. https://doi.org/10.22159/ijap.2023v15i6.48839

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