FORMULATION AND STABILITY EVALUATION OF ANTI-OBESITY NUTRACEUITCAL BLEND OF WHITE KIDNEY BEAN EXTRACT (PHASEOLUS VULGARIS L.), PROPOLIS ETHANOLIC EXTRACT AND CRPIC3

DOAA SALAH ELDIN ABDELFATTAH; MERVAT A. FOUAD; ALIAA N. ELMESHAD; MOHAMED A. El-NABARAWI; SAMMAR FATHY ELHABAL

doi:10.22159/ijap.2024v16i3.50705

Authors

DOAA SALAH ELDIN ABDELFATTAH National Nutrition Institute, Cairo-11435, Egypt. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Giza-11562, Egypt https://orcid.org/0000-0001-8449-2556
MERVAT A. FOUAD National Nutrition Institute, Cairo-11435, Egypt
ALIAA N. ELMESHAD Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Giza-11562, Egypt. Department of Pharmaceutics, Faculty of Pharmacy and Drug Technology, the Egyptian Chinese University, Cairo-11786, Egypt https://orcid.org/0000-0002-9454-7458
MOHAMED A. El-NABARAWI Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Giza-11562, Egypt https://orcid.org/0000-0003-0070-1969
SAMMAR FATHY ELHABAL Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo-11571, Egypt

DOI:

https://doi.org/10.22159/ijap.2024v16i3.50705

Keywords:

Obesity, Nutraceutical, WKBE, PEE, CrPic3, Hausner’s ratio, Carr’s index, Angle of repose, Disintegration, Stability study

Abstract

Objective: This study aimed to formulate and evaluate the stability profile of an anti-obesity nutraceutical combination in different dosage forms.

Methods: Active and inactive ingredients were formulated into pharmaceutical dosage forms. The quality parameters of the dosage forms were determined, followed by accelerated stability testing (40±2 °C and 75±5% Relative Humidity (RH)) for 180 d was completed to evaluate their physical, chemical and microbiological attributes throughout the storage period.

Results: Pre-formulation parameters of the powder blend of active and inactive ingredients for each dosage form showed a satisfactory flowability with Hausner's ratio falling between 1.16 and 1.18, average angle of repose between 22.29° and 22.90° and acceptable compressibility with Carr’s index below 25%. Tablets assessments were acceptable with a mean friability value of 0.21±0.03%, hardness of 4.12±0.09 kg/cm². The average disintegration time of 5 min 10 sec for tablets and 4 min and 30 sec for capsules. The accelerated stability study revealed that tablet dosage forms are stable for longer period that can reach up to 180 d (24 mo real-time), while sachets and capsules are stable for a period of 135 d (18 mo real-time).

Conclusion: The anti-obesity blend of White Kidney Bean Extract (WKBE), Propolis Ethanolic Extract (PEE) and CrPic₃ can be successfully formulated in acceptable and convenient dosage forms that can be stable for 18-24 mo.

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