EMERGING TRENDS IN STIMULI-SENSITIVE DRUG DELIVERY SYSTEM: A COMPREHENSIVE REVIEW OF CLINICAL APPLICATIONS AND RECENT ADVANCEMENTS

THAMARAI SELVAN DHANDAPANI; VIJAYARAGHAVAN KRISHNAN; BALAGEE MUTHUKUMAR; VIVEKANANDAN ELANGO; SAKTHI SHANMUGA JEYANDAR LAKSHMANAN; SAM HARRISON SAM JENKINSON; DHANDAPANI NAGASAMY VENKATESH

doi:10.22159/ijap.2023v15i6.48974

Authors

THAMARAI SELVAN DHANDAPANI Department of Pharmaceutics, JSS College of Pharmacy, (JSS Academy of Higher Education and Research, Mysuru) Ooty - 643 001. Nilgiris. Tamil Nadu, India https://orcid.org/0009-0004-8450-4982
VIJAYARAGHAVAN KRISHNAN Department of Pharmaceutics, JSS College of Pharmacy, (JSS Academy of Higher Education and Research, Mysuru) Ooty - 643 001. Nilgiris. Tamil Nadu, India https://orcid.org/0009-0007-5367-1923
BALAGEE MUTHUKUMAR Department of Pharmaceutical Analysis, JSS College of Pharmacy, (JSS Academy of Higher Education and Research, Mysuru) Ooty - 643 001. Nilgiris. Tamil Nadu. India https://orcid.org/0009-0003-2101-7848
VIVEKANANDAN ELANGO Department of Pharmaceutics, JSS College of Pharmacy, (JSS Academy of Higher Education and Research, Mysuru) Ooty - 643 001. Nilgiris. Tamil Nadu, India,
SAKTHI SHANMUGA JEYANDAR LAKSHMANAN Department of Pharmaceutics, JSS College of Pharmacy, (JSS Academy of Higher Education and Research, Mysuru) Ooty - 643 001. Nilgiris. Tamil Nadu, India
SAM HARRISON SAM JENKINSON Department of Pharmaceutical Biotechnology, JSS College of Pharmacy, (JSS Academy of Higher Education and Research, Mysuru) Ooty - 643 001. Nilgiris. Tamil Nadu. India https://orcid.org/0009-0006-8721-1987
DHANDAPANI NAGASAMY VENKATESH Department of Pharmaceutics, JSS College of Pharmacy, (JSS Academy of Higher Education and Research, Mysuru) Ooty - 643 001. Nilgiris. Tamil Nadu, India https://orcid.org/0000-0002-5361-3586

DOI:

https://doi.org/10.22159/ijap.2023v15i6.48974

Keywords:

Stimuli-sensitive drug delivery systems, Exogenous stimuli, Endogenous stimuli, Recent advancements

Abstract

The combination of fields such as applied physics, biology, computational modeling and analysis, pharmaceuticals, chemistry, optics, and material science study has been made easier for the rise of stimuli-sensitive drug delivery systems. This study aimed to overcome the shortcomings of conventional therapeutic approaches by concentrating on the most recent developments in stimuli-sensitive drug delivery systems, which are intended to accomplish the targeted release of drugs in specified areas. This review aims to provide an overview of stimuli-sensitive drug delivery systems and recent advancements between 2015 and 2023 by focusing on their ability to respond to exogenous and endogenous stimuli. In recent years, significant progress has been made in developing innovative stimuli-responsive drug delivery platforms that can trigger various external stimuli, such as light, temperature, magnetic fields, and ultrasound. These exogenous stimuli-responsive systems enable on-demand drug release at specific target sites, allowing for personalized and patient-centric treatment strategies. Notable breakthroughs include photoresponsive nanocarriers, thermosensitive hydrogels, and magnetic nanoparticles, all designed to respond to specific cues for controlled drug delivery.

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