BIOLOGICAL REACTIONS OF MACROPHAGES TO METAL OXIDE NANOPARTICLES
DOI:
https://doi.org/10.22159/ijap.2024v16i3.49928Keywords:
Nanotoxicology, Macrophages, Toxicity, Oxide metallic nanoparticlesAbstract
In our daily lives, nanomaterials are utilized extensively in paints, textiles, food goods, cosmetics, and medicine. Several investigations aim to deter investigations of the physiological effects in various cell types. The innate immune system's macrophages regulate a wide range of biological functions. Depending on the stimulus, macrophages can be activated toward pro- or anti-inflammatory (M1) phenotypes; however, polarization may change in conditions including cancer, autoimmune illnesses, and bacterial and viral infections. Metal oxide nanoparticles have recently gained significant interest due to their diverse range of unique features with applications in research and industry. The production and usage of nanomaterials will rise significantly as the nanotechnology business grows. As a result, testing the consequences of nanomaterial exposure in biological systems is critical. A comparative analysis is conducted on the toxicities of several metal oxide nanoparticles. The significance of biogenically generated metal oxide nanoparticles has been growing in recent years. However, more research is needed to thoroughly characterize the potential toxicity of these nanoparticles to ensure nanosafety and consider environmental views. To that end, nanotoxicology seeks to assess the toxicity of nanomaterials to physicochemical factors such as size and form. In this review, we focus on the biological reactions of macrophages to metal oxide nanoparticles. Because macrophages are the first cells to engage with nanoparticles when they enter the body, they can absorb them through various processes.
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Hornak J. Synthesis, properties, and selected technical applications of magnesium oxide nanoparticles: a review. International Journal of Molecular Sciences. 2021;22(23):12752.
Prado DC, Fernández I, Rodríguez-Páez JE. MgO nanostructures: Synthesis, characterization and tentative mechanisms of nanoparticles formation. Nano-structures & Nano-objects. 2020;23:100482.
Mahdi DF. Studying the effect of MgO addition on the thermal and electrical properties for Iraqi porcelain. Al-Nahrain Journal of Science. 2017;20(1):78-86.
Zhan Z, Sun W, Zhang S, Wen Q, Zhang H, Xiong X. (AlCrMg) x (PO4) y/MgO composite: A new thermal protection and insulation material up to 2400° C. Composites Part B: Engineering. 2022;245:110198.
Huang X, Kon E, Han X, Zhang X, Kong N, Mitchell MJ, Peer D, Tao W. Nanotechnology-based strategies against SARS-CoV-2 variants. Nature Nanotechnology. 2022;17(10):1027-37.
Dessale M, Mengistu G, Mengist HM. Nanotechnology: a promising approach for cancer diagnosis, therapeutics and theragnosis. International Journal of Nanomedicine. 2022;17:3735.
Malik S, Muhammad K, Waheed Y. Emerging applications of nanotechnology in healthcare and medicine. Molecules. 2023;28(18):6624.
Saadh MJ, Mohammed HK, Ameer AJ, Saraswat SK, Mohealdeen SM, Sailaw HA, Mudhafar M, Dawood FA, Elmasry Y. Improvement the formaldehyde sensing and detection through Pt-doped graphdiyne monolayer: Quantum chemical study. Diamond and Related Materials. 2023;140:110560.
Gavinho SR, Pádua AS, Holz LI, Sá-Nogueira I, Silva JC, Borges JP, Valente MA, Graça MP. Bioactive glasses containing strontium or magnesium ions to enhance the biological response in bone regeneration. Nanomaterials. 2023;13(19):2717.
Nejati M, Rostami M, Mirzaei H, Rahimi-Nasrabadi M, Vosoughifar M, Nasab AS, Ganjali MR. Green methods for the preparation of MgO nanomaterials and their drug delivery, anti-cancer and anti-bacterial potentials: A review. Inorganic Chemistry Communications. 2022;136:109107.
Xu H, Liu H, Liu C, Shangguan X, Cheng X, Zhang R, Lu Y, Li P, Cai Y. Molecular characterization and antibacterial ability of galectin-3 and galectin-9 in Onychostoma macrolepis. Developmental & Comparative Immunology. 2022;128:104333.
Hardikar Sr, Ansari Dm, Patil Na. Formulation Of Nanostructured Lipid Carriers Of Haloperidol Prepared By Using Clarified Butter. Int J App Pharm. 2023;15(2):213-8.
Saadh MJ, Alsaedi II, Abbood MA, Yadav A, ALsailawi HA, Mudhafar M, Al-Athari AJ, Elmasry Y, Alawadi AH. Therapeutic potential of CX (X= 48, 60, and 70) fullerenes as drug delivery carriers for ifosfamide anti-cancer drug. Diamond and Related Materials. 2023; 140:110494.
Joudeh N, Linke D. Nanoparticle classification, physicochemical properties, characterization, and applications: a comprehensive review for biologists. Journal of Nanobiotechnology. 2022; 20(1):262.
Zorah MO, Mustapa IR, Daud N, Jumah NA, Sudin NA, Majhool AL, Mahmoudi EB. Thermomechanical Study and Thermal Behavior of Plasticized Poly (Lactic Acid) Nanocomposites. Solid State Phenomena. 2021;317:333-40.
Muhaimin M, Chaerunisaa AY, Rostinawati T, Amalia E, Hazrina A, Nurhasanah S. A review on Nanoparticles of Moringa oleifera Extract: Preparation, Characterization, and Activity. Int. J. App. Pharm. 2023;15:43-51.
Pandit C, Roy A, Ghotekar S, Khusro A, Islam MN, Emran TB, Lam SE, Khandaker MU, Bradley DA. Biological agents for synthesis of nanoparticles and their applications. Journal of King Saud University-Science. 2022;34(3):101869.
Mudhafar M, Alsailawi HA, Zorah M, Karhib MM, Zainol I, Kadhim FK. Biogenic Synthesis and Characterization of AgNPs Using CEPS: Cytotoxicity and Antibacterial Activites. Journal of Advanced Research in Fluid Mechanics and Thermal Sciences. 2023;106(1):65-75.
Sudin NA, Daud NO, Mustapa IR, Zorah MO. Thermomechanical Properties and Thermal Behavior of Poly (Lactic Acid) Composites Reinforced with TiO2 Nanofiller. Solid State Phenomena. 2021;10(317):341-50.
Liu Y, Zhu S, Gu Z, Chen C, Zhao Y. Toxicity of manufactured nanomaterials. Particuology. 2022; 69:31-48.
Purohit HJ, Kapley A, Khardenavis A, Qureshi A, Dafale NA. Insights in waste management bioprocesses using genomic tools. Advances in applied microbiology. 2016; 97:121-70.
Pathy A, Ray J, Paramasivan B. Challenges and opportunities of nutrient recovery from human urine using biochar for fertilizer applications. Journal of Cleaner Production. 2021; 304:127019.
Taghavi Fardood S, Ramazani A, Woo Joo S. Eco-friendly synthesis of magnesium oxide nanoparticles using arabic Gum. Journal of Applied Chemical Research. 2018; 12(1):8-15.
Fahmy HM, El-Hakim MH, Nady DS, Elkaramany Y, Mohamed FA, Yasien AM, Moustafa MA, Elmsery BE, Yousef HA. Review on MgO nanoparticles multifunctional role in the biomedical field: Properties and applications. Nanomedicine Journal. 2022; 9(1).
Faisal S, Abdullah, Jan H, Shah SA, Shah S, Rizwan M, Zaman N, Hussain Z, Uddin MN, Bibi N, Khattak A. Bio-catalytic activity of novel Mentha arvensis intervened biocompatible magnesium oxide nanomaterials. Catalysts. 2021; 11(7):780.
Yang W, Li Y, Boraschi D. Association between Microorganisms and Microplastics: How Does It Change the Host–Pathogen Interaction and Subsequent Immune Response?. International Journal of Molecular Sciences. 2023;24(4):4065.
Pei J, Song R, Bao P, Yin M, Li J, Zhang G, Wu F, Luo Z, Wu X, Song W, Ba Y. Differential proteomic analysis demonstrates follicle fluid participate immune reaction and protein translation in yak. BMC Veterinary Research. 2022;18(1):34.
Manoussakis MN, Svolaki IP, Hazapis O, Zerva L, Gorgoulis VG, Magiorkinis G. Postgenomic Bioinformatic Analysis of Nucleic Acid Sequences Expressed in the Salivary Gland Epithelial Cells of Primary Sjögren’s Syndrome Patients in Search of Microorganisms and Endogenous Retroviruses. Mediterranean Journal of Rheumatology. 2022;33(3):371.
Alsailawi HA, Mudhafar M, Hanan AH, Ayat SS, Dhahi SJ, Ruaa KM, Raheem HA. Phytochemical screening and antibacterial activities of antiaris toxicaria stem, Polyalthia rumphii leaves and Polyalthia bullata stem extracts. InAIP Conference Proceedings 2023;2845(1). AIP Publishing.
Tame A, Maruyama T, Yoshida T. Phagocytosis of exogenous bacteria by gill epithelial cells in the deep-sea symbiotic mussel Bathymodiolus japonicus. Royal Society Open Science. 2022;9(5):211384.
Prakash J, Khan S, Chauhan S, Biradar AM. Metal oxide-nanoparticles and liquid crystal composites: A review of recent progress. Journal of Molecular Liquids. 2020;297:112052.
Thirupathi R, Solleti G, Sreekanth T, Sadasivuni KK, Venkateswara Rao K. A comparative study of chemically and biologically synthesized MgO nanomaterial for liquefied petroleum gas detection. Journal of Electronic Materials. 2018;47:3468-73.
Pirola L, Ferraz JC. Role of pro-and anti-inflammatory phenomena in the physiopathology of type 2 diabetes and obesity. World journal of biological chemistry. 2017;8(2):120.
Zorah MO, Mustapa IR, Daud N, Jumah NA, Sudin NA, Majhool AL, Mahmoudi EB. Thermomechanical Study and Thermal Behavior of Plasticized Poly (Lactic Acid) Nanocomposites. Solid State Phenomena. 2021;317:333-40.
Peluzzo AM, Autieri MV. Challenging the paradigm: Anti-inflammatory interleukins and angiogenesis. Cells. 2022; 11(3):587.
Mahedi MR, Rawat A, Rabbi F, Babu KS, Tasayco ES, Areche FO, Pacovilca-Alejo OV, Flores DD, Aguilar SV, Orosco FL, Syrmos N. Understanding the global transmission and demographic distribution of Nipah virus (NiV). Research Journal of Pharmacy and Technology. 2023; 16(8):3588-94.
Chojnacka K, Lewandowska U. Inhibition of pro-inflammatory cytokine secretion by polyphenol-rich extracts in macrophages via NF-κB pathway. Food Reviews International. 2023; 39(8):5459-78.
Majhool, AA, Zainol I, Azziz SSSA Jaafar CNA, Jahil MM. Mechanical properties improvement of epoxy composites by natural hydroxyapatite from fish scales as a filler. International Journal of Research in Pharmaceutical Sciences. 2019; 10(2):1424-1429.
Buonacera A, Stancanelli B, Colaci M, Malatino L. Neutrophil to lymphocyte ratio: an emerging marker of the relationships between the immune system and diseases. International journal of molecular sciences. 2022; 23(7):3636.
Vinchi F, Vance SZ. Reshaping erythrophagocytosis and iron recycling by reticuloendothelial macrophages. Hemasphere. 2021;5(2).
Mudhafar M, Zainol I, Alsailawi HA, Jaafar CN, Mohammed RK, Dhahi SJ. Preparation and characterization of beads of fish scales hydroxyapatite/collagen/silver nanoparticles by using infiltration method. Malaysian Journal of Microscopy. 2021; 17(2).
Saravanan A, Kumar PS, Vo DV, Jeevanantham S, Karishma S, Yaashikaa PR. A review on catalytic-enzyme degradation of toxic environmental pollutants: Microbial enzymes. Journal of Hazardous Materials. 2021; 419:126451.
Andlar M, Rezić T, Marđetko N, Kracher D, Ludwig R, Šantek B. Lignocellulose degradation: An overview of fungi and fungal enzymes involved in lignocellulose degradation. Engineering in Life Sciences. 2018; 18(11):768-78.
Mudhafar M, Zainol I, Jaafar CN, Alsailawi HA, Majhool AA. Microwave-assisted green synthesis of Ag nanoparticles using leaves of Melia Dubia (Neem) and its antibacterial activities. Journal of Advanced Research in Fluid Mechanics and Thermal Sciences. 2020;65(1):121-9.
Khan FA. Nanomaterials: types, classifications, and sources. Applications of nanomaterials in human health. 2020:1-3.
Chauhan A, Khan T, Omri A. Design and encapsulation of immunomodulators onto gold nanoparticles in cancer immunotherapy. International Journal of Molecular Sciences. 2021; 22(15):8037.
Ishihara S, Iwasaki T, Kohashi K, Kawaguchi K, Toda Y, Fujiwara T, Setsu N, Endo M, Matsumoto Y, Nakashima Y, Oda Y. Clinical significance of signal regulatory protein alpha and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain expression in undifferentiated pleomorphic sarcoma. Journal of Cancer Research and Clinical Oncology. 2023;149(6):2425-36.
Zhang CC. A perspective on LILRBs and LAIR1 as immune checkpoint targets for cancer treatment. Biochemical and Biophysical Research Communications. 2022; 633:64-7.
Shprakh ZS, Poskedova YA, Ramenskaya GV. Modern instrumental methods for qualitative and quantitative analysis of lapatinib in biological fluids and dosage forms. International Journal of Applied Pharmaceutics. 2022;14(1):7-12.
Bayda S, Adeel M, Tuccinardi T, Cordani M, Rizzolio F. The history of nanoscience and nanotechnology: from chemical–physical applications to nanomedicine. Molecules. 2019; 25(1):112.
Gojznikar J, Zdravković B, Vidak M, Leskošek B, Ferk P. TiO2 nanoparticles and their effects on eukaryotic cells: a double-edged sword. International Journal of Molecular Sciences. 2022;23(20):12353.
Joudeh N, Linke D. Nanoparticle classification, physicochemical properties, characterization, and applications: a comprehensive review for biologists. Journal of Nanobiotechnology. 2022;20(1):262.
Khan D, Bedner P, Müller J, Lülsberg F, Henning L, Prinz M, Steinhäuser C, Muhammad S. TGF-β Activated Kinase 1 (TAK1) Is Activated in Microglia After Experimental Epilepsy and Contributes to Epileptogenesis. Molecular Neurobiology. 2023;60(6):3413-22.
Mudhafar, M., Zainol, I., Alsailawi, H., Karhib, M., Zorah, M., Alnagdi, F., Hamzah, M. S. Bioactive Chemical Constituents Of Three Crude Extracts Of Polyalthia Sclerophylla Using GC-Mass And Phytochemical Screening And Their Antibacterial And Cytotoxicity Activities. Eurasian Chemical Communications, 2023; 5(8): 675-690. Doi: 10.22034/Ecc.2023.387999.1602
Zorah, M., Mudhafar, M., Naser, H. A., & Mustapa, I. R. The Promises of the Potential Uses of Polymer Biomaterials in Biomedical Applications and Their Challenges. International Journal of Applied Pharmaceutics, 2023; 15(4), 27–36.
Kafeel U, Jahan U, Raghib F, Khan FA. Global Importance and Cycling of Nanoparticles. In the Role of Nanoparticles in Plant Nutrition under Soil Pollution: Nanoscience in Nutrient Use Efficiency 2022; 2, 1-20.
Zorah M, Mustapa IR, Daud N, Nahida JH, Sudin NA. Effects of Tributyl Citrate Plasticizer on Thermomechanical Attributes of Poly Lactic Acid. Journal of Advanced Research in Fluid Mechanics and Thermal Sciences. 2019;62(2):274-84.
Khalid UA, Afolabi BL, Abdullahi A, Attah EI, Toor AA, Saleem R, Khan SJ, Liaqat A. Nano-carriers based combating approach against antibiotic resistance: an insight into nanoparticles based peptide delivery. International Journal of Molecular Microbiology.2023; 6(1):1-23.
Ivanov AI, Lechuga S, Marino‐Melendez A, Naydenov NG. Unique and redundant functions of cytoplasmic actins and nonmuscle myosin II isoforms at epithelial junctions. Annals of the New York Academy of Sciences. 2022;1515(1):61-74.
Kage F, Vicente-Manzanares M, McEwan BC, Kettenbach AN, Higgs HN. Myosin II proteins are required for organization of calcium-induced actin networks upstream of mitochondrial division. Molecular Biology of the Cell. 2022;33(7):ar63.
Kumar J, Mitra MD, Hussain A, Kaul G. Exploration of immunomodulatory and protective effect of Withania somnifera on trace metal oxide (zinc oxide nanoparticles) induced toxicity in Balb/c mice. Molecular biology reports. 2019; 46:2447-59.
Nikolova MP, Chavali MS. Metal oxide nanoparticles as biomedical materials. Biomimetics. 2020;5(2):27.
Sengul AB, Asmatulu E. Toxicity of metal and metal oxide nanoparticles: a review. Environmental Chemistry Letters. 2020; 18:1659-83.
Mudhafar M, Zainol I, Alsailawi HA, Zorah M, Karhib MM. Preparation and characterization of FsHA/FsCol beads: Cell attachment and cytotoxicity studies. Heliyon. 2023;9(5).
Zielińska A, Costa B, Ferreira MV, Miguéis D, Louros JM, Durazzo A, Lucarini M, Eder P, V. Chaud M, Morsink M, Willemen N. Nanotoxicology and nanosafety: Safety-by-design and testing at a glance. International Journal of Environmental Research and Public Health. 2020; 17(13):4657.
Xing Q, Feng Y, Sun H, Yang S, Sun T, Guo X, Ji F, Wu B, Zhou D. Scavenger receptor MARCO contributes to macrophage phagocytosis and clearance of tumor cells. Experimental Cell Research. 2021; 408(2):112862.
Garcés M, Cáceres L, Chiappetta D, Magnani N, Evelson P. Current understanding of nanoparticle toxicity mechanisms and interactions with biological systems. New Journal of Chemistry. 2021; 45(32):14328-44.
Joudeh N, Linke D. Nanoparticle classification, physicochemical properties, characterization, and applications: a comprehensive review for biologists. Journal of Nanobiotechnology. 2022; 20(1):262.
Mudhafar M, Zainol I, Jaafar CN, Alsailawi HA, Majhool AA, Alsaady M. Phytochemical Screening and Characterization of Meliadubia Leaves Extract for Antimicrobial Activity against Escherichia coli and Staphylococcus aureus. Indian Journal of Ecology. 2020;47(2):493-6.
Sarmah P, Dan MM, Adapa D, Sarangi TK. A review on common pathogenic microorganisms and their impact on human health. Electronic Journal of Biology. 2018; 14(1):50-8.
Xia Y, Rao L, Yao H, Wang Z, Ning P, Chen X. Engineering macrophages for cancer immunotherapy and drug delivery. Advanced Materials. 2020; 32(40):2002054.
Lee JI, Chang YP, Tsai CS, Yen CF. Internalized sexual stigma among lesbian, gay, and bisexual individuals in Taiwan: Its related factors and association with mental health problems. International journal of environmental research and public health. 2022; 19(4):2427.
Tian L, Lei A, Tan T, Zhu M, Zhang L, Mou H, Zhang J. Macrophage-based combination therapies as a new strategy for cancer immunotherapy. Kidney Diseases. 2022; 8(1):26-43.
Zainurin Ma, Zainol I, Jaafar Cn, Mudhafar M. The Effect of Yttria-Stabilized Zirconia (Ysz) Addition on the Synthesis of Βeta-Tricalcium Phosphate (Β-Tcp) From Biogenic Hydroxyapatite. Malaysian Journal of Microscopy. 2023; 19(1):66-75.
Bi J, Mo C, Li S, Huang M, Lin Y, Yuan P, Liu Z, Jia B, Xu S. Immunotoxicity of metal and metal oxide nanoparticles: From toxic mechanisms to metabolism and outcomes. Biomaterials Science. 2023; 11(12):4151-83.
Alja’afreh IY, Alaatabi RM, Hussain Aldoghachi FE, Mudhafar M, Almashhadani HA, Kadhim MM, Hassan Shari F. Study the antioxidant of Matricaria chamomilla (Chamomile) powder: In vitro and vivo. Revis Bionatura 2023; 8 (1) 63.
Canaparo R, Foglietta F, Limongi T, Serpe L. Biomedical applications of reactive oxygen species generation by metal nanoparticles. Materials. 2020; 14(1):53.
Mudhafar M, Zainol I, Aiza Jaafar CN, Alsailawi HA, Desa Sh A. Review Synthesis Methods of Ag Nanoparticles: Antibacterial and Cytotoxicity. International Journal of Drug Delivery Technology. 2021;11(2):635..
Muhammad Q, Jang Y, Kang SH, Moon J, Kim WJ, Park H. Modulation of immune responses with nanoparticles and reduction of their immunotoxicity. Biomaterials science. 2020; 8(6):1490-501.
Miao R, Lim VY, Kothapalli N, Ma Y, Fossati J, Zehentmeier S, Sun R, Pereira JP. Hematopoietic stem cell niches and signals controlling immune cell development and maintenance of immunological memory. Frontiers in immunology. 2020; 11:600127.
Rodríguez-Hernández AG, Vazquez-Duhalt R, Huerta-Saquero A. Nanoparticle-plasma membrane interactions: thermodynamics, toxicity and cellular response. Current Medicinal Chemistry. 2020; 27(20):3330-45.
Johnston NR, Strobel SA. Principles of fluoride toxicity and the cellular response: a review. Archives of toxicology. 2020; 94(4):1051-69.
Poh TY, Ali NA, Mac Aogáin M, Kathawala MH, Setyawati MI, Ng KW, Chotirmall SH. Inhaled nanomaterials and the respiratory microbiome: clinical, immunological and toxicological perspectives. Particle and fibre toxicology. 2018; 15:1-6.
Zainol I, Zainurin MA, Bakar NH, Jaafar CN, Mudhafar M. Characterisation of porous hydroxyapatite beads prepared from fish scale for potential bone filler applications. Malaysian Journal of Microscopy. 2022; 18(2):48-57.
Reichel D, Tripathi M, Perez JM. Biological effects of nanoparticles on macrophage polarization in the tumor microenvironment. Nanotheranostics. 2019; 3(1):66.
Wu Y, Kang J, Zhang L, Liang Z, Tang X, Yan Y, Qian H, Zhang X, Xu W, Mao F. Ubiquitination regulation of inflammatory responses through NF-κB pathway. American Journal of Translational Research. 2018; 10(3):881.
Mudhafar M, Alsailawi HA, Jaafar CN. Synthesis, characterisation, cytotoxicity and antibacterial studies of green synthesised silver nanoparticles using leaves of polyalthia sclerophylla. Malaysian Journal of Microscopy. 2022; 18(2):79-91.
Yadav PK, Kochar C, Taneja L, Tripathy SS. Study on dissolution behavior of CuO nanoparticles in various synthetic media and natural aqueous medium. Journal of Nanoparticle Research. 2022;24(6):122.
Huang Y, Hsu JC, Koo H, Cormode DP. Repurposing ferumoxytol: Diagnostic and therapeutic applications of an FDA-approved nanoparticle. Theranostics. 2022; 12(2):796.
Dong Z, Si G, Zhu X, Li C, Hua R, Teng J, Zhang W, Xu L, Qian W, Liu B, Wang J. Diagnostic performance and safety of a novel ferumoxytol-enhanced coronary magnetic resonance angiography. Circulation: Cardiovascular Imaging. 2023; 16(7):580-90.
Yan S, Hu K, Zhang M, Sheng J, Xu X, Tang S, Li Y, Yang S, Si G, Mao Y, Zhang Y. Extracellular magnetic labeling of biomimetic hydrogel-induced human mesenchymal stem cell spheroids with ferumoxytol for MRI tracking. Bioactive Materials. 2023; 19:418-28.
Boraschi D, Alijagic A, Auguste M, Barbero F, Ferrari E, Hernadi S, Mayall C, Michelini S, Navarro Pacheco NI, Prinelli A, Swart E. Addressing nanomaterial immunosafety by evaluating innate immunity across living species. Small. 2020; 16(21):2000598.
Swartzwelter BJ, Mayall C, Alijagic A, Barbero F, Ferrari E, Hernadi S, Michelini S, Navarro Pacheco NI, Prinelli A, Swart E, Auguste M. Cross-species comparisons of nanoparticle interactions with innate immune systems: A methodological review. Nanomaterials. 2021; 11(6):1528.
Boraschi D, Swartzwelter BJ, Italiani P. Interaction of engineered nanomaterials with the immune system: health-related safety and possible benefits. Current Opinion in Toxicology. 2018; 10:74-83.
Boraschi D, Li D, Li Y, Italiani P. In vitro and in vivo models to assess the immune-related effects of nanomaterials. International Journal of Environmental Research and Public Health. 2021; 18(22):11769.
Halamoda-Kenzaoui B, Vandebriel RJ, Howarth A, Siccardi M, David CA, Liptrott NJ, Santin M, Borgos SE, Bremer-Hoffmann S, Caputo F. Methodological needs in the quality and safety characterisation of nanotechnology-based health products: Priorities for method development and standardisation. Journal of Controlled Release. 2021; 336:192-206.
Nakayama M. Macrophage recognition of crystals and nanoparticles. Frontiers in immunology. 2018; 9:103.
Mudhafar M, Alsailawi H, Zainol I, Hamzah Ms, Jawad S, Dhahi Rk. The Natural and Commercial Sources Of Hydroxyapatite/Collagen Composites for Biomedical Applications: A Review Study. Int J App Pharm. 2022; 14(4):77-87.
Mudhafar M, Zainol I, Alsailawi HA, Jaafar CN, Mohammed RK, Dhahi SJ. Preparation and characterization of beads of fish scales hydroxyapatite/collagen/silver nanoparticles by using infiltration method. Malaysian Journal of Microscopy. 2021;17(2).
Hirayama D, Iida T, Nakase H. The phagocytic function of macrophage-enforcing innate immunity and tissue homeostasis. International journal of molecular sciences. 2017; 19(1):92.
Lecoultre M, Dutoit V, Walker PR. Phagocytic function of tumor-associated macrophages as a key determinant of tumor progression control: a review. Journal for immunotherapy of cancer. 2020; 8(2).
Wu MY, Lu JH. Autophagy and macrophage functions: inflammatory response and phagocytosis. Cells. 2019; 9(1):70.
Zorah M, Mudhafar M, Majhool AA, Abbood SF, Alsailawi HA, Karhib MM, Mustapa IR. Review of the Green Composite: Importance of Biopolymers, Uses and Challenges. Journal of Advanced Research in Fluid Mechanics and Thermal Sciences. 2023;111(1):194-216.
Zhao C, Pu W, Niu M, Wazir J, Song S, Wei L, Li L, Su Z, Wang H. Respiratory exposure to PM2. 5 soluble extract induced chronic lung injury by disturbing the phagocytosis function of macrophage. Environmental Science and Pollution Research. 2022:1-5.
Pinheiro CD, Monteiro AP, Dutra FF, Bozza MT, Peters-Golden M, Benjamim CF, Canetti C. Short-Term Regulation of FcγR-Mediated Phagocytosis by TLRs in Macrophages: Participation of 5-Lipoxygenase Products. Mediators of Inflammation. 2017; 2017:2086840.
Nath PR, Pal-Nath D, Kaur S, Gangaplara A, Meyer TJ, Cam MC, and Roberts DD. Loss of CD47 alters CD8+ T cell activation in vitro and immunodynamics in mice. Oncoimmunology. 2022; 11(1):2111909.
Cvetković Z, Pantić N, Cvetković M, Virijević M, Sabljić N, Marinković G, Milosavljević V, Pravdić Z, Suvajdžić-Vuković N, Mitrović M. The Role of the Spleen and the Place of Splenectomy in Autoimmune Hemolytic Anemia—A Review of Current Knowledge. Diagnostics. 2023; 13(18):2891.
Qu J, Jin J, Zhang M, Ng LG. Neutrophil diversity and plasticity: Implications for organ transplantation. Cellular & Molecular Immunology. 2023; 20(9):993-1001.
McComb S, Thiriot A, Akache B, Krishnan L, Stark F. Introduction to the immune system. Immunoproteomics: Methods and Protocols. 2019:1-24.
Sudin NA, Mustapa IR, Daud N, Zorah M. Thermomechanical, Crystallization and Melting Behavior of Plasticized Poly (Lactic Acid) Nanocomposites. Solid State Phenomena. 2021; 317:351-60.
He Y, de Araújo Júnior RF, Cruz LJ, Eich C. Functionalized nanoparticles targeting tumor-associated macrophages as cancer therapy. Pharmaceutics. 2021; 13(10):1670.
Zorah M, Mustapa IR, Daud N, Nahida JH, Sudin NA, Majhool AA, Mahmoudi E. Improvement thermomechanical properties of polylactic acid via titania nanofillers reinforcement. Journal of Advanced Research in Fluid Mechanics and Thermal Sciences. 2020; 70(1):97-111.
Zainurin MA, Zainol I. Biogenic Synthesis Of Silver Nanoparticles Using Neem Leaf Extract As Reducing Agent And Hydrolyzed Collagen As Stabilizing Agent. Malaysian Journal of Microscopy. 2022; 18(1).
Acharya D. Interplay between Phagocytosis and Proinflammatory Cytokine Production in Macrophages. University of Toronto (Canada); 2018.
Peng H, Wang J, Song X, Huang J, Hua H, Wang F, Xu Z, Ma J, Gao J, Zhao J, Nong A. PHLDA1 suppresses TLR4-triggered proinflammatory cytokine production by interaction with tollip. Frontiers in Immunology. 2022; 13:731500.
Koper-Lenkiewicz OM, Sutkowska K, Wawrusiewicz-Kurylonek N, Kowalewska E, Matowicka-Karna J. Proinflammatory cytokines (IL-1,-6,-8,-15,-17,-18,-23, TNF-α) single nucleotide polymorphisms in rheumatoid arthritis—a literature review. International Journal of Molecular Sciences. 2022; 23(4):2106.
Omar AE, Al-Khalaifah HS, Osman A, Gouda A, Shalaby SI, Roushdy EM, Abdo SA, Ali SA, Hassan AM, Amer SA. Modulating the growth, antioxidant activity, and immunoexpression of proinflammatory cytokines and apoptotic proteins in broiler chickens by adding dietary spirulina platensis phycocyanin. Antioxidants. 2022; 11(5):991.
Mudhafar M, Zainol I, Alsailawi HA, Jaafar CN, Mohammed RK, Dhahi SJ. Preparation and characterization of beads of fish scales hydroxyapatite/collagen/silver nanoparticles by using infiltration method. Malaysian Journal of Microscopy. 2021; 17(2).
Chen J, Song Y, Wang Q, Li Q, Tan H, Gao J, Zhang N, Weng X, Sun D, Yakufu W, Wang Z. Targeted neutrophil-mimetic liposomes promote cardiac repair by adsorbing proinflammatory cytokines and regulating the immune microenvironment. Journal of Nanobiotechnology. 2022; 20(1):218.
Izdebska M, Zielińska W, Hałas-Wiśniewska M, Grzanka A. Involvement of actin and actin-binding proteins in carcinogenesis. Cells. 2020; 9(10):2245.
Mudhafar M, Zainol I, Aiza Jaafar CN, Alsailawi HA, Desa Sh A. Review Synthesis Methods of Ag Nanoparticles: Antibacterial and Cytotoxicity. International Journal of Drug Delivery Technology. 2021; 11(2):635.
Zeng C, Zhang H. Mechanisms of Actin-binding Protein Transgelin-2 in Tumorigenesis. Discovery Medicine. 2021; 32(165):23-8.
Wang L, Yan M, Wu S, Wu X, Bu T, Wong CK, Ge R, Sun F, Cheng CY. Actin binding proteins, actin cytoskeleton and spermatogenesis–lesson from toxicant models. Reproductive Toxicology. 2020; 96:76-89.
Li K, Underhill DM. C-type lectin receptors in phagocytosis. C-type lectins in immune homeostasis. 2020:1-8.
Zhang LF, Lepenies B, Nakamae S, Young BM, Santos RL, Raffatellu M, Cobb BA, Hiyoshi H, Bäumler AJ. The VI Capsular Polysaccharide of Salmonella Typhi Promotes Macrophage Phagocytosis by Binding the Human C-Type Lectin DC-SIGN. Mbio. 2022; 13(6):e02733-22.
Angelina A, Martín-Cruz L, de la Rocha-Muñoz A, Lavín-Plaza B, Palomares O. C-type lectin receptor mediated modulation of T2 immune responses to allergens. Current Allergy and Asthma Reports. 2023; 23(3):141-51.
Nurhidayah Mu, Fadilah Fa, Arsianti A, Bahtiar An. Identification Of Fgfr Inhibitor As St2 Receptor/Interleukin-1 Receptor-Like 1 Inhibitor In Chronic Obstructive Pulmonary Disease Due To Exposure To E-Cigarettes By Network Pharmacology And Molecular Docking Prediction. Int J App Pharm. 2022; 14(2):256-66.
Almayahi WM, Saeed Abbas S, Abbas BA. Molecular Detection and Histopathological Effect of Infectious Bronchitis Virus Circulating in Vaccinated Broiler Flocks in Basrah, Iraq. Iranian Journal of War and Public Health. 2022; 14(3):339-45.
Tian G, Huang C, Li Z, Lu Z, Feng C, Zhuang Y, Li G, Liu P, Hu G, Gao X, Guo X. Baicalin mitigates nephropathogenic infectious bronchitis virus infection-induced spleen injury via modulation of mitophagy and macrophage polarization in Hy-Line chick. Veterinary Microbiology. 2023; 286:109891.
Mudhafar M, Zainol I, Alsailawi HA, Aiza Jaafar CN. Green Synthesis of Silver Nanoparticles using Neem and Collagen of Fish Scales as a Reducing and Stabilizer Agents. Jordan Journal of Biological Sciences. 2021; 14(5).
Hoerr FJ. The pathology of infectious bronchitis. Avian Diseases. 2021; 65(4):600-11.
Omran TZ, Ali BAM, Ali HM, Abdulazeez AA, Alsailawi HA, Mudhafar M. Bacterial resistance of the most locally isolated pathogens to commonly used antibiotics in Kerbala/Iraq. Multidisciplinary Science Journal. 2023;6(6):2024096.
de Oliveira Viana IM, Roussel S, Defrêne J, Lima EM, Barabé F, Bertrand N. Innate and adaptive immune responses toward nanomedicines. Acta Pharmaceutica Sinica B. 2021; 11(4):852-70.
Yusefi-Tanha E, Fallah S, Rostamnejadi A, Pokhrel LR. Particle size and concentration dependent toxicity of copper oxide nanoparticles (CuONPs) on seed yield and antioxidant defense system in soil grown soybean (Glycine max cv. Kowsar). Science of the Total Environment. 2020; 715:136994.
Saadh MJ, Alsaedi II, Abbood MA, Yadav A, ALsailawi HA, Mudhafar M, Al-Athari AJ, Elmasry Y, Alawadi AH. Therapeutic potential of CX (X= 48, 60, and 70) fullerenes as drug delivery carriers for ifosfamide anti-cancer drug. Diamond and Related Materials. 2023;140:110494.
Alsailawi HA, Misnan R, Mudhafar M. Major and minor allergen Ige reactivity of purple mud crab (Scylla tranquebarica) against a cross-reactive allergen in crustacean and molluscs in patients with a seafood allergy. Research Journal of Pharmacy and Technology. 2021; 14(1):239-44.
Abd El-Kader MF, Elabbasy MT. Gamma radiation modified the optical, electrical, and antibacterial characterization of CuONPs doped in polyethylene oxide/polyvinyl alcohol. Journal of Materials Research and Technology. 2020; 9(6):16179-85.
Joshi NC, Prakash YA. Leaves extract-based biogenic synthesis of cupric oxide nanoparticles, characterizations, and antimicrobial activity. Asian J. Pharm. Clin. Res. 2019; 12:288-91.
Birusanti Ab, Mallavarapu U, Nayakanti D, Espenti Cs. Plant-Mediated Zno Nanoparticles Using Ficus Racemosa Leaf Extract And Their Characterization, Antibacterial Activity. Asian J Pharm Clin Res. 2018;11(9):463-7.
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Copyright (c) 2024 MOHAMMED ZORAH, HASSAN LAFTA ATIYAH, NOOR WATHTHAB ALI, RUAA K. MOHAMMED JAWAD, FATIMAH H. ZAYED, MUSTAFA MUDHAFAR, ALSAILAWI H. A., SAIF AHMED RAHEEM
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