COMPARATIVE STUDIES OF NOVEL OXADIAZOLE DERIVATIVE HAVING CHIRAL CENTER ANDTHEIRANTI-MICROBIAL ACTIVITIES
Keywords:
1,3,4-Oxadiazol, Spectroscopic study, Antibacterial activity, Antifungal activityAbstract
Objective: To synthesize a series of (-) S & (+) S oxadiazole derivatives by the reaction of (-) (2S)-2-amino-2-(2-chlorophenyl) acetohydrazide & (+) (2S)-2-amino-2-(2-chloro phenyl) acetohydrazide with con. H2SO4, L(+) Tartaric acid, L(-) Tartaric acid, Hydrazine Hydrate, POCl3 and Various aromatic acid respectively.
Methods: The structures of novel synthesized compounds have been established on the basis of elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data and screened for their antibacterial and antifungal activities against different microorganisms by micro dilution method. Gentamycin, Ampicillin, Chloramphenicol, Ciprofloxacin, Norfloxacin, Nystatin, Greseofulvin were used as standard drugs for bacterial and fungus.
Results: The newly synthesized compounds indicate that some of them show better antibacterial and antifungal activity than compared to their reference drug.
Conclusion: Comparison of 1, 3, 4 oxadiazole having chiral center, characterized and exhibited promising antibacterial and antifungal activity.
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References
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