• Aishwarya S Saveetha university
  • Sohara Parveen
  • Vishnupriya V
  • Gayathri R



Objective: Estimation of serum zinc and copper levels in anemic patients.

Methods: The study design included 30 subjects presenting to clinical laboratory, global hospitals. The subjects were divided into 2 groups. The
Group 1 consists of 15 healthy individuals and Group 2 consists of 15 anemic patients.

Results: The serum copper and zinc levels were evaluated in anemic patients. The serum copper and zinc were found to be significantly lower in  anemic patients when compared with normal individuals.

Conclusion: Thus, the study concludes that the serum zinc and copper in anemic patients is significantly less when compared to the control individuals.
Hence, it is important to add adequate amount of zinc and copper rich food in their diet to control the prevalence of anemia.

Keywords: Anemia, Zinc, Copper, Hemoglobin.


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Fayet-Moore F, Petocz P, Samman S. Micronutrient status in female university students: iron, zinc, copper, selenium, vitamin B12 and folate. Nutrients 2014;6(11):5103-16.

World Health Organization. The World Health Report 2002: Reducing Risks, Promoting Healthy Life styles. Geneva, Switzerland: World Health Organization; 2002.

Samman S. Iron. Nutr Diet 2007;64(Suppl S4):S126-30.

Petkova-Marinovan T, Nedkova V, Bojinova A, Angelova M. Iron Deficiency Anaemia Under 3 years of Age and Some Essential Trace Elements. Electronic International Interdisciplinary Conference. September, 2-6; 2013.

Manser WW. Disease: Abnormalities of copper, zinc and magnesium in blood. J Pak Med Assoc. 1989;39(12):325-33.

Neumann PZ, Sass-Kortsak A. The state of copper in human serum: evidence for an amino acid-bound fraction. J Clin Invest 1967;46(4):646-58.

Margalioth EJ, Udassin R, Maor J, Schenker JG. Serum copper level in ovarian carcinoma. Cancer 1985;56(4):856-9.

Shakoor HA, Jamil K, Amanat ST, Waqar F, Yawar W, Raza M. Serum copper in anemic patients. J Rawalpindi Med Coll (JRMC) 2014;18(2):196-8.

McMahon LP. Iron deficiency in pregnancy. Obstet Med 2010;3:17-24.

Rajeswari S, Swaminathan S. Role of copper in health and diseases. Int J Curr Sci 2014;10:e94-107.

Ademasu A, Kerisew B, Nibret E, Munshea A, Adal M. Serum zinc deficiency and associated factors among pre-ART and on-ART adults at Felege Hiwot referral Hospital, Bahir Dar, Northwest Ethiopia. Int J Nutr Food Sci 2014;3(4):311-7.

Caddell JL. A review of evidence for a role of magnesium and possibly copper deficiency in necrotizing enterocolitis. Magnes Res 1996;9(1):55-66.

Alarcón OM, Reinosa Fuller J, Silva TM, Angarita C, Terán E, Navas M, et al. Serum level of Zn, Cu and Fe in healthy schoolchildren residing in Mérida, Venezuela. Arch Latinoam Nutr 1997;47(2):118-22.

Lindahl M, Leanderson P, Tagesson C. Novel aspect on metal fume fever: zinc stimulates oxygen radical formation in human neutrophils. Hum Exp Toxicol 1998;17(2):105-10.

Prasad A. Effect of zinc deficiency on immune function. J Trace Elements Exp Med 2000;13:1-20.

Solomons NW. On the assessment of zinc and copper nutriture in man. Am J Clin Nutr 1979;32(4):856-71.

Danks DM. Diagnosis of trace metal deficiency – with emphasis on copper and zinc. Am J Clin Nutr 1981;34(2):278-80.

Kenn C, Gibb E. The role of zinc in senile dementia. Br J Psychiatry 1986;149:221-3.

Halsted JA, Ronaghy HA, Abadi P, Haghshenass M, Amirhakemi GH, Barakat RM, et al. Zinc deficiency in man. The Shiraz experiment. Am J Med 1972;53(3):277-84.

Angelova MG, Petkova-Marinova TV, Pogorielov MV, Loboda AN, Nedkova-Kolarova VN, Bozhinova AN. Trace Element Status (Iron, Zinc, Copper, Chromium, Cobalt, and Nickel) in Iron-Deficiency Anaemia of Children under 3 Years. Anemia 2014;2014:718089.

Gropper SS, Bader-Crowe DM, McAnulty LS, White BD, Keith RE. Non-anemic iron depletion, oral iron supplementation and indices of copper status in college-aged females. J Am Coll Nutr 2002;21(6):545-52.

Shah F, Kazi TG, Afridi HI, Kazi N, Baig JA, Shah AQ, et al. Evaluation of status of trace and toxic metals in biological samples (scalp hair, blood, and urine) of normal and anemic children of two age groups. Biol Trace Elem Res 2011;141(1-3):131-49.

World Health Organization, Iron Deciency Anemia: Assessment, Prevention, and Control - A Guide for Program Managers. Geneva, Switzerland: World Health Organization; 2001.

Stoltzfus RJ, Mullany L, Black RE. Iron deficiency anaemia. In: Ezzati M, Lopez AD, Rodgers A, Murray CJ, editors. Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attribution to Selected Major Risk Factors. Geneva, Switzerland: World Health Organization; 2004. p. 164-5.

Voskaki I, Arvanitidou V, Athanasopoulou H, Tzagkaraki A, Tripsianis G, Giannoulia-Karantana A. Serum copper and zinc levels in healthy greek children and their parents. Biol Trace Elem Res 2010;134(2):136-45.

Wajeunnesa M, Begum N, Ferdousi S, Akhter S, Quarishi SB. Serum zinc and copper in iron de cient adoles - cents. J Bangladesh Soc Physiol 2009;4(2):77-80.

Gürgöze MK, Olçücü A, Aygün AD, Taskin E, Kiliç M. Serum and hair levels of zinc, selenium, iron, and copper in children with iron-deficiency anemia. Biol Trace Elem Res 2006;111(1-3):23-9.

Ece A, Uyanik BS, Iscan A, Ertan P, Yigitoglu MR. Increased serum copper and decreased serum zinc levels in children with iron deficiency anemia. Biol Trace Elem Res 1997;59(1-3):31-9.

Hasanato RM. Zinc and antioxidant vitamin deficiency in patients with severe sickle cell anemia. Ann Saudi Med 2006;26(1):17-21.

Karayalcin G, Lanzkowsky P, Kazi AB. Zinc deficiency in children with sickle cell disease. Am J Pediatr Hematol Oncol 1979;1(3):283-4.

Niell HB, Leach BE, Kraus AP. Zinc metabolism in sickle cell anemia. JAMA 1979;242(24):2686-7.

Prasad AS, editor. Clinical spectrum of human zinc deficiency. Vol. 2. Biochemistry of Zinc. New York: Plenum Press; 1993. p. 19-58.

Prasad AS. Zinc deficiency in patients with sickle cell disease. Am J Clin Nutr 2002;75(2):181-2.

Harless W, Crowell E, Abraham J. Anemia and neutropenia associated with copper deficiency of unclear etiology. Am J Hematol 2006;81:546-9.



How to Cite

S, A., S. Parveen, V. V, and G. R. “ESTIMATION OF SERUM COPPER AND ZINC IN ANAEMIC PATIENTS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 5, Sept. 2016, pp. 162-4, doi:10.22159/ajpcr.2016.v9i5.12892.



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