APOPTOTIC INDUCTION POTENTIALS OF BACOPA MONERI AGAINST ORAL CANCER CELL LINE

Keerthana B; Gayathri R; Vishnu Priya V

doi:10.22159/ajpcr.2016.v9i5.13162

Authors

Keerthana B Saveetha Dental College http://orcid.org/0000-0001-6438-9738
Gayathri R
Vishnu Priya V

DOI:

https://doi.org/10.22159/ajpcr.2016.v9i5.13162

Abstract

Aim: To assess the apoptotic induction potentials of Bacopa monnieri against oral cancer cell.

Objective: This research is done to find the apoptotic induction potentials of B. monnieri against oral cancer cell line.

Background: The apoptosis is a process of programed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell
changes and death. The initiation of apoptosis is tightly regulated by activation mechanisms, because once apoptosis has begun, it inevitably leads
to the death of the cell. The two best-understood activation mechanisms are the intrinsic pathway (also called the mitochondrial pathway) and the
extrinsic pathway.

Methods: The apoptotic induction potential of B. monnieri was studied on KB cell line by investigating the activation of caspase 3 and caspase 9.
Reason: Oral cancer is a growing concern due to the changes in lifestyle. The treatment for this disease has been degraded the patient's health by
causing various side effects. An effective treatment for the long run is necessary. Usable of herbal plants can serve to be a possible and very effective remedy.

Results: Apoptotic induction potentials of B. monnieri against oral cancer cell line were studied.

Conclusion: Caspase 3 and caspase 9 was activated thus proving the apoptotic potential of B. monnieri.

Keywords: Bacopa monnieri, oral cancer, apoptotic induction.

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Author Biography

Keerthana B, Saveetha Dental College

I BDS Student

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