• ARAVINTH RAJKUMAR G Department of Orthodontics, Saveetha Dental College and Hospitals, Chennai - 600 077, Tamil Nadu, India
  • Gayathri R Department of Biochemistry, Saveetha Dental College and Hospital, Chennai - 600 077, Tamil Nadu, India.
  • Vishnupriya V Department of Biochemistry, Saveetha Dental College and Hospital, Chennai - 600 077, Tamil Nadu, India.



Nanoparticles, Targeted drug delivery, Nanomedicine, Cancer therapeutics, Carrier systems



 The challenge of drug delivery is the liberation of drug agents at the right time in a safe and reproducible manner, usually to a specific target site. Conventional dosage forms, such as orally administered pills and subcutaneous or intravenous injection, are the predominant routes for drug administration. However, pills and injections offer limited control over the rate of drug release into the body; usually, they are involved in an immediate release of the drug. This article is about how nanoparticles can be used as an effective drug delivery system to target the drug to a specific location or organ.


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Carregal-Romero S, Ochs M, Parak WJ. Nanoparticle-Functionalized Microcapsules for in vitro Delivery and Sensing, Nanophotonics. Berlin, Boston: Science Wise Publishing and de Gruyter; 2012. p. 171-80.

Park K. Facing the truth about nanotechnology in drug delivery. J Am Chem Soc Nano 2013;7:7442-7.

Suri SS, Fenniri H, Singh B. Nanotechnology-based drug delivery systems. J Occup Med Toxicol 2007;2:16.

Sinha R, Kim GJ, Nie S, Shin DM. Nanotechnology in cancer therapeutics: Bioconjugated nanoparticles for drug delivery. Mol Cancer Ther 2006;5(8):1909-17.

Liu Z, Tabakman S, Welsher K, Dai H. Carbon nanotubes in biology and medicine: In vitro and in vivo detection, imaging and drug delivery. Nano Res 2009;2(2):85-120.

Gu W, Wu C, Chen J, Xiao Y. Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration. Int J Nanomedicine 2013;8:2305-17.

Vasir JK, Labhasetwar V. Targeted drug delivery in cancer therapy. Technol Cancer Res Treat 2005;4(4):363-74.

Manhole AS, Sakarkar DM, Mahajan NM. Nanoparticles-tremendous therapeutic potential: A review. Int J Pharmtech Res 2009;1(4):1020-7.

Jain MD. Recent advances in nanooncology. Technol Cancer Res Treat 2008;7(1):1-13.

Shi J, Votruba AR, Farokhzad OC, Lancer R. Nanotechnology in drug delivery and tissue engineering: From discovery to applications. Nano Lett 2010;10(9):3223-30.

Zhang L, Gu FX, Chan JM, Wang AZ, Langer RS, Farokhzad OC. Nanoparticles in medicine: Therapeutic applications and developments. Clin Pharmacol Ther 2008;83(5):761-9.

Bride AA, Patel V, Gavard J, Zhang G, Sousa AA, Richard D, et al. Rusling, targeted killing of cancer cells in vivo and in vitro with

EGF- directed carbon nanotube-based drug delivery. Am Chem Soc Nano 2009;3(2):307-16.

Shubayev VI, Pisanic TR, Jin S. Magnetic nanoparticles for telegnostic. Adv Drug Deliv Rev 2009;61(6):467-77.

Wissing SA, Kayser O, Muller RH. Solid lipid nanoparticles for parenteral drug delivery. Adv Drug Deliv Rev 2004;56(9):1257-72.

Soppimath US, Aminabhavi TM, Kulkarni AR, Rudzinski WE. Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release 2001;70(1-2):1-20.

Salata O. Applications of nanoparticles in biology and medicine. J Nanobiotechnology 2004;2:3.

Menjoge AR, Kannan RM, Tomalia DA. Dendrimer-based drug and imaging conjugates: Design considerations for nanomedical applications. Drug Discov Today 2010;15(5-6):171-85.

Jong WH, Born PJ. Drug delivery and nanoparticles: Applications and hazards. Int J Nanomed 2008;3(2):133-49.

Jain N, Jain R, Thakur N, Prakashgupta B, Jain D, Jain S, et al. Nanotechnology: A Safe and effective drug delivery system. Asian J Pharm Clin Res 2010;3(3):159-65.

Revathi S, Vuyyuru M, Dhanaraju MD. Carbon nanotube: A flexible approach for nanomedicine and drug delivery. Asian J Pharm Clin Res 2015;8(1):25-31.

Kumar P, Roy I. Applications of gold nanoparticles in clinical medicine. Int J Pharm Pharm Sci 2016;8(7):9-16.

Hemant K, Raizaday A, Sivadasu P, Uniyal S, Kumar SH. Cancer nanotechnology: Nanoparticulate drug delivery for the treatement of cancer. Int J Pharm Pharm Sci 2015;7(3):40-6.



How to Cite

G, A. R., G. R, and V. V. “TARGETING THE TARGET USING NANOPARTICLES - A REVIEW”. Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 12, Dec. 2017, pp. 6-10, doi:10.22159/ajpcr.2017.v10i12.19734.



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