THE ANTIBACTERIAL POTENTIAL OF N-ACETYLCYSTEINE AS AN ENDODONTIC IRRIGANT ON THE CLINICAL ISOLATES OF THE ENTEROCOCCUS FAECALIS BIOFILM

Ridzki Ridhalaksani; Kamizar Nazar; Nila Kesuma Djauharie; Ratna Meidyawati; Dewa Ayu Npa

doi:10.22159/ijap.2017.v9s2.05

Authors

Ridzki Ridhalaksani Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia
Kamizar Nazar Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia
Nila Kesuma Djauharie Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia
Ratna Meidyawati Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia
Dewa Ayu Npa Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia

DOI:

https://doi.org/10.22159/ijap.2017.v9s2.05

Keywords:

Enterococcus faecalis, Biofilm, Irrigation, N-acetylcystein

Abstract

Objective: The aim of this study was to evaluate the antibacterial potential of NAC as an endodontic irrigant on the clinical isolates of the Enterococcus faecalis biofilm.

Methods: NAC with a pH of 2.5 and 11 (NAC pH 2.5 and NAC pH 11, respectively) were exposed to clinical isolates of E. faecalis biofilms for 1 min. The NAC samples were compared to 2% chlorhexidine (CHX), which is commonly used as an irrigant in persistent infections. The antibacterial potential of these irrigants was evaluated by comparing the bacterial count of the E. faecalis colonies after they were exposed to the irrigants.

Results: The NAC pH 2.5 test group showed a reduction in the E. faecalis colonies, but this reduction was not statistically significant when compared to the 2% CHX group results. The NAC pH 11 test group showed the greatest reduction in bacterial colonies, and this reduction was statistically significant when compared to the NAC pH 2.5 and 2% CHX groups' results.

Conclusion: NAC pH 11 has antibacterial potential on the clinical isolates of E. faecalis biofilms.

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