EFFECTIVENESS OF A JAVANESE TURMERIC ETHANOL EXTRACT FOR ERADICATING STREPTOCOCCUS MUTANS AND PORPHYROMONAS GINGIVALIS BIOFILMS
DOI:
https://doi.org/10.22159/ijap.2019.v11s1.AR157Keywords:
Biofilm eradication, Dual-species biofilm, Identified Javanese turmeric ethanolic extract, Single-species biofilm, Streptococcus mutans, Porphyromonas gingivalisAbstract
Objective: We aimed to determine the effectiveness of an identified Javanese turmeric ethanolic extract (IIJTEE) for eradicating biofilms formed by
Streptococcus mutans, Porphyromonas gingivalis, or both.
Methods: Such biofilms during different growth phases were exposed to various concentrations of an IJTEE to determine its effects on bacterial
proliferation.
Results: The effectiveness of the IJTEE in eradicating the S. mutans biofilm was concentration-dependent but not when used to treat P. gingivalis and
S. mutans - P. gingivalis biofilms.
Conclusion: The effectiveness of the IJTEE for eradicating biofilms formed by S. mutans, P. gingivalis, and S. mutans plus P. gingivalis biofilms depended
on the growth phase of the biofilm. Thus, IJTEE eradicated biofilms formed by S. mutans, P. gingivalis, or both.
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Fig. 4: Effectiveness of the Javanese turmeric ethanolic extract in biofilms formed by Streptococcus mutans combined with P. gingivalis
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Research. Jakarta: Indonesian Ministry of Health; 2013. p. 110-3.
2. World Health Organization. Geneva; 2012. Available from: http://www.
who.int/mediacentre/factsheet/fs318/en/. [Last cited on 2015 Oct 01].
3. Metwalli KH, Khan SA, Krom BP, Jabra-Rizk MA. Streptococcus
mutans, Candida albicans, and the human mouth: A sticky situation.
PLoS Pathog 2013;9:e1003616.
4. Kokare CR, Chakraborty S, Khopade AN, Mahadik KR. Biofilm:
Importance and applications. Indian J Biotechnol 2009;8:159-68.
5. Onisei D, Onisei D, Feier I, Rusu D, Stratul SI. The biofilm: Formation
and removal. Timisoara Med J 2008;58:111-7.
6. Kimura S, Nemoto YO, Shimoyama Y, Ishikawa T, Sasaki M.
Pathogenic factors of P. gingivalis and the host defense mechanisms.
In: Buduneli N, editors. Pathogenesis and Treatment of Periodontitis.
Croatia: InTech; 2012. p. 3-18.
7. Tomás I, Rubido S, Donos N. In situ antimicrobial activity of
chlorhexidine in the oral cavity. In: Mendez-Vilas A, editors. Science
Against Microbial Pathogens: Communicating Current Research and
Fig. 4: Effectiveness of the Javanese turmeric ethanolic extract in biofilms formed by Streptococcus mutans combined with P. gingivalis
Int J App Pharm, Vol 11, Special Issue 1, 2019
Technological Advances. Spain: Formatex Research Center; 2011.
p. 530-41.
8. Indonesian Food and Drugs Administration Agency. National
Movement of Drinking Javanese Turmeric. Vol. 6. InfoPOM Website;
2005. p. 1-12.
9. Health Research and Development Agency. Indonesian Basic Health
Research. Jakarta: Indonesian Ministry of Health; 2010. p. 417-28.
10. Hwang JK, Shim JS, Pyun YR. Antibacterial activity of xanthorrhizol
from Curcuma xanthorrhiza against oral pathogens. Fitoterapia
2000;71:321-3.
11. Rukayadi Y, Hwang JK. In vitro activity of xanthorrhizol against
Streptococcus mutans biofilms. Lett Appl Microbiol 2006;42:400-4.
12. Mangunwardoyo W, Deasywaty, Usia T. Antimicrobial and
identification of active compound Curcuma xanthorrhiza Roxb. Int J
Basic Appl Sci IJENS 2012;12:69-78.
13. Harvey RA, Champe PC, Fisher BD. Microbiology. 2nd ed. Philadelphia,
PA: Lippincott Williams and Wilkins; 2007. p. 51.
14. Chadha T. Bacterial biofilms: Survival mechanisms oral antibiotic
resistance. J Bacteriol Parasitol 2014;5:1-4.
15. Wang BY, Alvarez P, Hong J, Kuramitsu HK. Periodontal pathogens
interfere with quorrum-sensing-dependent virulence properties in
Streptococcus mutans. J Periodontal Res 2011;46:105-10.
16. Høiby N, Bjarnsholt T, Givskov M, Molin S, Ciofu O. Antibiotic
resistance of bacterial biofilms. Int J Antimicrob Agents 2010;35:322-32.
17. Stewart PS, Consterton JW. Antibiotic resistance of bacteria in biofilms.
Lancet 2001;358:135-8.
Published
05-04-2019
How to Cite
ROSYANA, M., SUNIARTI, D. F., & SARWONO, A. T. (2019). EFFECTIVENESS OF A JAVANESE TURMERIC ETHANOL EXTRACT FOR ERADICATING STREPTOCOCCUS MUTANS AND PORPHYROMONAS GINGIVALIS BIOFILMS. International Journal of Applied Pharmaceutics, 11(1), 27–31. https://doi.org/10.22159/ijap.2019.v11s1.AR157
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