FORMULATION OF ENTERIC GRANULES CONTAINING GREEN TEA (CAMELLIA SINENSIS) EXTRACT USING EUDRAGIT L100-55 AS A DELAYED RELEASE MATRIX

EFFIONORA ANWAR; JESSICA RAMADHANTY VALENSYA SHERMAN

doi:10.22159//ijap.2020.v12s1.FF028

Authors

EFFIONORA ANWAR Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia
JESSICA RAMADHANTY VALENSYA SHERMAN Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia

DOI:

https://doi.org/10.22159//ijap.2020.v12s1.FF028

Keywords:

Delayed release, Enteric, Epigallocatechin gallate, Eudragit L100-55, Granules, Green tea (Camellia sinensis) extract

Abstract

Objective: Epigallocatechin gallate (EGCG) inhibits glucose absorption into the blood by inhibiting small intestinal α-glucosidase but is unstable in
gastric fluid. Hence, we formulated EGCG into enteric preparations that prevent release in gastric fluid.
Methods: Granules were prepared using a wet granulation method and were formulated into polyvinylpyrrolidone (PVP)-Eudragit L100-55 (5:1; F1),
PVP-Eudragit L100-55 (1:1; F2), and Eudragit L100-55 (F3) preparations using 30% w/w Eudragit L100-55 as a matrix. EGCG contents of granules
were evaluated and dissolution tests were performed at pH 1.2 and 6.8.
Results: F1–3 formulas had good flow properties and contained EGCG at 24.05%±0.15%–24.96%±0.28%. Dissolution tests showed that F1 and F2
formulas released EGCG at 50.53%±0.04% and 17.80%±0.55%, respectively, after 2 h in HCl medium at pH 1.2. Cumulative drug release from F1 and
F2 formulations after 2 h under these conditions (pH 1.2) and 1 h in phosphate buffer (pH 6.8) was 94.40%±1.58% and 93.70%±1.08%, respectively.
Conclusion: As the optimal formula, F3 granules limited drug release to 7.03%±0.22% in HCl at pH 1.2 over 2 h and cumulative drug release in HCl
medium (pH 1.2) followed by phosphate buffer (pH 6.8) of 86.13%±0.20%.

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