SNEDDS AS LIPID-BASED NANOCARRIER SYSTEMS: CONCEPTS AND FORMULATION INSIGHTS
DOI:
https://doi.org/10.22159/ijap.2022v14i2.42930Keywords:
In vitro assessment of self-emulsification, Lipid-based drug delivery systems (LBDDS), oxidative stress and CCl4, Low solubility, Dibutyl phthalateAbstract
Approximately 40 % of newly discovered chemical entities have low solubility and possess low bioavailability after oral administration. Lipid-based drug delivery systems (LBDDS) have recently become very popular because of their remarkable ability to deliver drugs with poor absorption using lipids as carriers. Self-emulsifying drug delivery (SEDDS) systems are one type of LBDDS employed for the incorporation of hydrophobic drugs. SEDDS are classified into self-micro emulsifying drug delivery systems (SMEDDS) and self-nano emulsifying drug delivery systems (SNEDDS) based on the droplet size of the dispersed phase. The present review focus on the mechanism of drug absorption from lipid-based nanocarriers systems, in vitro assessment of self-emulsification, insights of SNEDDS, factors affecting the formulation of SNEDDS, and its applications.
Downloads
References
Kuentz M. Oral self-emulsifying drug delivery systems, from biopharmaceutical to technical formulation aspects. J Drug Deliv Sci Technol. 2011;21(1):17-26. doi: 10.1016/S1773-2247(11)50002-4.
Thomas N, Rades T, Müllertz A. Recent developments in oral lipid-based drug delivery. J Drug Deliv Sci Technol. 2013;23(4):375-82. doi: 10.1016/S1773-2247(13)50054-2.
Hauss DJ. Oral lipid-based formulations. Adv Drug Deliv Rev. 2007;59(7):667-76. doi: 10.1016/j.addr.2007.05.006, PMID 17618704.
Karami Z, Saghatchi Zanjani MR, Nasihatsheno N, Hamidi M. Improved oral bioavailability of repaglinide, a typical BCS class II drug, with a chitosan‐coated nanoemulsion. J Biomed Mater Res B Appl Biomater. 2020;108(3):717-28. doi: 10.1002/jbm.b.34426, PMID 31187938.
Rao SV, Yajurvedi K, Shao J. Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of protein drugs: III. In vivo oral absorption study. Int J Pharm. 2008;362(1-2):16-9. doi: 10.1016/j.ijpharm.2008.05.015, PMID 18650037.
Porter CJ, Pouton CW, Cuine JF, Charman WN. Enhancing intestinal drug solubilisation using lipid-based delivery systems. Adv Drug Deliv Rev. 2008;60(6):673-91. doi: 10.1016/j.addr.2007.10.014, PMID 18155801.
Ijaz H, Qureshi J, Tulain UR, Iqbal F, Danish Z, Fayyaz A, Sethi A. Lipid particulate drug delivery systems: a review. Bioinspired Biomimetic Nanobiomater. 2018;7(2):109-21. doi: 10.1680/ jbibn.16.00039.
Liu H, Shang K, Liu W, Leng D, Li R, Kong Y, Zhang T. Improved oral bioavailability of glyburide by a self-nanoemulsifying drug delivery system. J Microencapsul. 2014;31(3):277-83. doi: 10.3109/02652048.2013.843598, PMID 24533514.
Savjani KT, Gajjar AK, Savjani JK. ChemInform abstract: drug solubility: importance and enhancement techniques. ChemInform. 2013;44(26). doi: 10.1002/chin.201326246.
Date AA, Desai N, Dixit R, Nagarsenker M. Self-nanoemulsifying drug delivery systems: formulation insights, applications and advances. Nanomedicine (Lond). 2010;5(10):1595-616. doi: 10.2217/nnm.10.126, PMID 21143036.
Jannin V, Musakhanian J, Marchaud D. Approaches for the development of solid and semi-solid lipid-based formulations. Adv Drug Deliv Rev. 2008;60(6):734-46. doi: 10.1016/j.addr.2007.09.006, PMID 18045728.
Khan AW, Kotta S, Ansari SH, Sharma RK, Ali J. Potentials and challenges in self-nanoemulsifying drug delivery systems. Expert Opin Drug Deliv. 2012;9(10):1305-17. doi: 10.1517/17425247.2012.719870, PMID 22954323.
Prabhu S, Ortega M, Ma C. Novel lipid-based formulations enhancing the in vitro dissolution and permeability characteristics of a poorly water-soluble model drug, piroxicam. Int J Pharm. 2005;301(1-2):209-16. doi: 10.1016/j.ijpharm.2005.05.032, PMID 16046087.
Kumar M, Bishnoi RS, Shukla AK, Jain CP. Techniques for formulation of nanoemulsion drug delivery system: a review. Prev Nutr Food Sci. 2019;24(3):225-34. doi: 10.3746/pnf.2019.24.3.225, PMID 31608247.
Elgart A, Cherniakov I, Aldouby Y, Domb AJ, Hoffman A. Improved oral bioavailability of BCS Class 2 compounds by self nano-emulsifying drug delivery systems (SNEDDS): the underlying mechanisms for amiodarone and talinolol. Pharm Res. 2013;30(12):3029-44. doi: 10.1007/s11095-013-1063-y, PMID 23686373.
Guccione C, Bergonzi MC, Awada KM, Piazzini V, Bilia AR. Lipid nanocarriers for oral delivery of serenoa repens CO2 Extract: A study of microemulsion and self-microemulsifying drug delivery systems. Planta Med. 2018;84(9-10):736-42. doi: 10.1055/a-0589-0474, PMID 29544228.
Nabi B, Rehman S, Baboota S, Ali J. Insights on oral drug delivery of lipid nanocarriers: a win-win solution for augmenting bioavailability of antiretroviral drugs. AAPS PharmSciTech. 2019;20(2):60. doi: 10.1208/s12249-018-1284-9, PMID 30623263.
Yadav NK, Shukla T, Upmanyu N, Pandey SP, Khan MA. Novel application of mixed hydrotropic solubilization technique in the formulation and evaluation of solid dispersion of flupirtine maleate. J Drug Delivery Ther. 2018;8(5):481-8. doi: 10.22270/jddt.v8i5.1911.
Zubair M, Pradhan RA, Arshad M, Ullah A. Recent advances in lipid derived bio‐based materials for food packaging applications. Macromol Mater Eng. 2021;306(7). doi: 10.1002/mame.202000799, PMID 2000799.
Pandey V, Kohli S. Lipids and surfactants: the inside story of lipid-based drug delivery systems. Critical Reviews™ in Therapeutic Drug Carrier Systems. 2018;35(2):99-155.
Jain S, Jain V, Mahajan SC. Lipid based vesicular drug delivery systems. Adv Pharm. 2014;2014:1-12. doi: 10.1155/2014/574673.
Gupta S, Kesarla R, Omri A. Formulation strategies to improve the bioavailability of poorly absorbed drugs with special emphasis on self-emulsifying systems. ISRN Pharm. 2013;2013:848043. doi: 10.1155/2013/848043, PMID 24459591.
Kovvasu SP, Kunamaneni P, Yeung S, Rueda J, Betageri GV. Formulation of dronedarone hydrochloride-loaded proliposomes: in vitro and in vivo evaluation using Caco-2 and rat model. AAPS PharmSciTech. 2019;20(6):226. doi: 10.1208/s12249-019-1437-5, PMID 31214813.
Aboul Fotouh K, Allam AA, El-Badry M, El-Sayed AM. Self-emulsifying drug–delivery systems modulate P-glycoprotein activity: role of excipients and formulation aspects. Nanomedicine (Lond). 2018;13(14):1813-34. doi: 10.2217/ nnm-2017-0354, PMID 30074420.
Cherniakov I, Domb AJ, Hoffman A. Self-nano-emulsifying drug delivery systems: an update of the biopharmaceutical aspects. Expert Opin Drug Deliv. 2015;12(7):1121-33. doi: 10.1517/17425247.2015.999038, PMID 25556987.
Kabir MT, Munir MS, Rahman MA. Self-emulsifying drug delivery system (SEDDS): an approach for solubility, dissolution and bioavailability enhancement of furosemide. Scholars Acad J Pharm. 2016;5(7):289-96. doi: 10.21276/ sajp.2016.5.7.5.
Amira MG. Spray dried self-nanoemulsifying drug delivery systems for sertraline HCl: pharmacokinetic study in healthy volunteers. Int J Pharm Sci Dev Res. 2018:009-19. doi: 10.17352/ijpsdr.000017.
Hosny KM, Hassan AH. Intranasal in situ gel loaded with saquinavir mesylate nanosized microemulsion: preparation, characterization, and in vivo evaluation. Int J Pharm. 2014;475(1-2):191-7. doi: 10.1016/j.ijpharm.2014.08.064, PMID 25178831.
Buya AB, Beloqui A, Memvanga PB, Preat V. Self-nano-emulsifying drug-delivery systems: from the development to the current applications and challenges in oral drug delivery. Pharmaceutics. 2020;12(12):11-65. doi: 10.3390/ pharmaceutics12121194, PMID 33317067.
Morakul B. Self-nanoemulsifying drug delivery systems (SNEDDS): an advancement technology for oral drug delivery. Pharm Sci Asia. 2020;47(3):205-20. doi: 10.29090/ psa.2020.03.019.0121.
Gursoy RN, Benita S. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother. 2004;58(3):173-82. doi: 10.1016/j.biopha.2004.02.001, PMID 15082340.
Kazi M, Al-Swairi M, Ahmad A, Raish M, Alanazi FK, Badran MM, Khan AA, Alanazi AM, Hussain MD. Evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for poorly water-soluble talinolol: preparation, in vitro and in vivo assessment. Front Pharmacol. 2019;10:459. doi: 10.3389/fphar.2019.00459, PMID 31118895.
Nikolakakis I, Partheniadis I. Self-emulsifying granules and pellets: composition and formation mechanisms for instant or controlled release. Pharmaceutics. 2017;9(4):1-50. doi: 10.3390/pharmaceutics9040050, PMID 29099779.
Xiao L, Yi T, Liu Y. A new self-micro emulsifying mouth dissolving film to improve the oral bioavailability of poorly water soluble drugs. Drug Dev Ind Pharm. 2013;39(9):1284-90. doi: 10.3109/03639045.2012.723716, PMID 23009066.
Tran P, Park J. Recent trends of self-emulsifying drug delivery system for enhancing the oral bioavailability of poorly water-soluble drugs. J Pharm Investig. 2021;51(4):439-63. doi: 10.1007/s40005-021-00516-0.
Kazi M, Shahba AA, Alrashoud S, Alwadei M, Sherif AY, Alanazi FK. Bioactive self-nanoemulsifying drug delivery systems (bio-SNEDDS) for combined oral delivery of curcumin and piperine. Molecules. 2020;25(7):1-24. doi: 10.3390/ molecules25071703, PMID 32276393.
Basalious EB, Shawky N, Badr-Eldin SM. SNEDDS containing bioenhancers for improvement of dissolution and oral absorption of lacidipine. I: Development and optimization. Int J Pharm. 2010;391(1-2):203-11. doi: 10.1016/j.ijpharm. 2010.03.008, PMID 20214965.
Khan AW, Kotta S, Ansari SH, Sharma RK, Ali J. Self-nanoemulsifying drug delivery system (SNEDDS) of the poorly water-soluble grapefruit flavonoid Naringenin: design, characterization, in vitro and in vivo evaluation. Drug Deliv. 2015;22(4):552-61. doi: 10.3109/10717544.2013.878003. PMID 24512268.
Sampathi S, Achanta R, Tiriya P, Gera S, Reddy PS, Talla V. Formulation and evaluation of carvedilol loaded lactide nnanoparticles: aan aappraisal to aanti-hhypertensive and aanti-iinflammatory ttherapy. Adv Sci Engng Med. 2016;8(7):503-14. doi: 10.1166/asem.2016.1886.
Chavda H, Patel J, Chavada G, Dave S, Patel A, Patel C. Self-nanoemulsifying powder of isotretinoin: preparation and characterization. Journal of Powder Technology. 2013;2013:1-9. doi: 10.1155/2013/108569.
Baloch J, Sohail MF, Sarwar HS, Kiani MH, Khan GM, Jahan S, Rafay M, Chaudhry MT, Yasinzai M, Shahnaz G. Self-nanoemulsifying drug delivery system (SNEDDS) for improved oral bioavailability of chlorpromazine: in vitro and in vivo Eevaluation. Medicina (Kaunas). 2019;55(5):1-13. doi: 10.3390/medicina55050210, PMID 31137751.
Yoo JH, Shanmugam S, Thapa P, Lee ES, Balakrishnan P, Baskaran R, Yoon SK, Choi HG, Yong CS, Yoo BK, Han K. Novel self-nanoemulsifying drug delivery system for enhanced solubility and dissolution of lutein. Archives of Pharmacal Research. 2010;33(3):417-26. doi: 10.1007/s12272-010-0311-5, PMID 20361307.
Alghananim A, Ozalp Y, Mesut B, Serakinci N, Ozsoy Y, Gungor S. A solid ultra fine self-nanoemulsifying drug delivery system (S-SNEDDS) of deferasirox for improved solubility: optimization, characterization, and in vitro cytotoxicity studies. Pharmaceuticals (Basel). 2020;13(8):1-24. doi: 10.3390/ph13080162, PMID 32722238.
Mahmoud DB, Shukr MH, Bendas ER. In vitro and in vivo evaluation of self-nanoemulsifying drug delivery systems of cilostazol for oral and parenteral administration. International Journal of Pharmaceutics. 2014;476(1-2):60-9. doi: 10.1016/j.ijpharm.2014.09.045, PMID 25269009.
Seo YG, Kim DH, Ramasamy T, Kim JH, Marasini N, Oh YK, Kim DW, Kim JK, Yong CS, Kim JO, Choi HG. Development of docetaxel-loaded solid self-nanoemulsifying drug delivery system (SNEDDS) for enhanced chemotherapeutic effect. International Journal of Pharmaceutics. 2013;452(1-2):412-20. doi: 10.1016/j.ijpharm.2013.05.034, PMID 23707964.
Miao Y, Chen G, Ren L, Pingkai O. Characterization and evaluation of self-nanoemulsifying sustained-release pellet formulation of ziprasidone with enhanced bioavailability and no food effect. Drug Delivery. 20142016;23(7):2163-72. doi: 10.3109/10717544.2014.950768, PMID 25148542.
Date AA, Nagarsenker MS. Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil. International Journal of Pharmaceutics. 2007;329(1-2):166-72. doi: 10.1016/j.ijpharm.2006.08.038, PMID 17010543.
Zhang J, Peng Q, Shi S, Zhang Q, Sun X, Gong T, Zhang Z. Preparation, characterization, and in vivo evaluation of a self-nanoemulsifying drug delivery system (SNEDDS) loaded with morin-phospholipid complex. Int J Nanomedicine. 2011;6:3405-14. doi: 10.2147/IJN.S25824. PMID 22267925.
Alaa A. Kassem AA, Maha A. Marzouk MA, Amal A, Ammar AA, Elosaily GH. Preparation and in vitro evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) containing clotrimazole. Drug Discoveries and Therapeutics. 2010;4(5):373-9. PMID 22491242.
Balakumar K, Raghavan CV, Selvan NT, Prasad RH, Abdu S. Self nanoemulsifying drug delivery system (SNEDDS) of rosuvastatin calcium: design, formulation, bioavailability and pharmacokinetic evaluation. Colloids and Surfaces B: Biointerfaces. 2013;112:337-43. doi: 10.1016/j.colsurfb.2013.08.025, PMID 24012665.
Nasr A, Gardouh A, Ghorab M. Novel solid self-nanoemulsifying drug delivery system (S-SNEDDS) for oral delivery of olmesartan medoxomil: design, formulation, pharmacokinetic and bioavailability evaluation. Pharmaceutics. 2016;8(3):20-45. doi: 10.3390/pharmaceutics8030020, PMID 27355963.
A Rahman MA, Mujahid M, Hussain AM, Mujahid M, Hussain A. Self-emulsifying pellets prepared by extrusion/spheronization: in vitro/in vivo evaluation. Recent Patents on Drug Delivery and Formulation. 2016;10(3):245-52. doi: 10.2174/ 1872211310666161021105035, PMID 27774911.
Gohel M, Purohit A, Patel A, Hingorani L. Optimization of bacoside a loaded snedds using d-optimal mixture design for enhancement insolubility and bioavailability. Int J Pharm Pharm Sci. 2016;8(12):213-20. doi: 10.22159/ ijpps.2016v8i12.13488.
Published
How to Cite
Issue
Section
Copyright (c) 2022 LAKSHMI DEVI GOTTEMUKKULA, SUNITHA SAMPATHI
This work is licensed under a Creative Commons Attribution 4.0 International License.
