A REVIEW ON CHITOSAN-BASED MATERIALS AS POTENTIAL WOUND DRESSING MATERIALS

Authors

  • DOLIH GOZALI Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jl Raya Bandung-Sumedang Km, 21 Jatinangor, Indonesia 45363
  • ANNISA RAFASHAFLY HUDAYA Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jl Raya Bandung-Sumedang Km, 21 Jatinangor, Indonesia 45363
  • INE SUHARYANI Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jl Raya Bandung-Sumedang Km, 21 Jatinangor, Indonesia 45363, Sekolah Tinggi Farmasi Muhammadiyah Cirebon, Jl. Cideng Indah No. 3, Kedawung, Cirebon, West Java, Indonesia 45153

DOI:

https://doi.org/10.22159/ijap.2022.v14s4.PP23

Keywords:

Chitosan, Wound healing, Wound dressing, Biomedical field

Abstract

This review article aimed to study chitosan as a material based in wound dressing preparation. The method in this review is the approximation method. The articles were obtained from national and international journals such as Scopus, PubMed, and Google Scholar by using the keywords "Chitosan", "Wound Healing", and "Biomedical Application". The inclusion criteria of the article are: national and international journals and books contains chitosan as, published in the last ten years, and not review article. The final articles used in this review are 29 articles that studying the use of chitosan as wound dressing material. The combination of chitosan with some polymer, ion and other materials resulting the chitosan-based materials namely nanofibrous membranes, composites sponge, polyelectrolyte complex, and composites, that used in topical preparation such as membranes, fibers, sponge, film, and gel. Thus, the modified of chitosan wound healing preparation resulting in the improve of healing activity of each preparation from. This review summarizes chitosan application in wound healing. Several studies were proposed the porous structure of chitosan-based materials lead the improvement of healing activity.

Downloads

Download data is not yet available.

References

Granick MS, Baetz NW, Labroo P, Milner S, Li WW, Sopko NA SN. In vivo expansion and regeneration of full-thickness functional skin with an autologous homologous skin construct clinical proof of concept for chronic wound healing. Int Wound J. 2019;16(3):841-6. doi: 10.1111/iwj.13109, PMID 30868746.

Loo HL, Goh BH, Lee LH, Chuah LH. Application of chitosan-based nanoparticles in skin wound healing. Asian J Pharm Sci. 2022;17(3):299-332. doi: 10.1016/j.ajps.2022.04.001, PMID 35782330.

Patrulea V, Ostafe V, Borchard G, Jordan O. Chitosan as a starting material for wound healing applications. Eur J Pharm Biopharm. 2015;97(B):417-26. doi: 10.1016/j.ejpb. 2015.08.004, PMID 26614560.

Boateng JS, Matthews KH, Stevens HN, Eccleston GM. Wound healing dressings and drug delivery systems: a review. J Pharm Sci. 2008;97(8):2892-923. doi: 10.1002/jps.21210, PMID 17963217.

Sarmento B, Neves D. Chitosan-based systems for biopharmaceuticals: delivery, targeting and polymer therapeutics. John Wiley & Sons; 2012.

Pages E, Pastore M, Rosselle L. An ex vivo human skin model for healing of infected wounds. J Invest Dermatol. 2019;139.

Yao Z, Niu J, Cheng B. Prevalence of chronic skin wounds and their risk factors in an inpatient hospital setting in Northern China. Adv Skin Wound Care. 2020;33(9):1-10. doi: 10.1097/01.ASW.0000694164.34068.82. PMID 32740027.

Park J, Song E, Jeong S, Song J, Kim H, Kim S. Chitosan-based dressing materials for problematic wound management wound healing. Dressing Materials Chitosan 2018. doi: 10.1007/978-981-13-0947-2.

Alven S, Aderibigbe BA. Chitosan and cellulose-based hydrogels for wound management. Int J Mol Sci. 2020;21(24):1-30. doi: 10.3390/ijms21249656, PMID 33352826.

Feng W, Wang Z. Biomedical applications of chitosan-graphene oxide nanocomposites. Science. 2022;25(1):103629. doi: 10.1016/j.isci.2021.103629. PMID 35106467.

Wang K, Pan S, Qi Z, Xia P, Xu H, Kong W. Recent advances in chitosan-based metal nanocomposites for wound healing applications. Adv Mater Sci Eng. 2020;2020:1-13. doi: 10.1155/2020/3827912.

Moradi S, Hamedi H, Tonelli AE, King MW. Chitosan/graphene oxide composite films and their biomedical and drug delivery applications: a review. Appl Sci. 2021;11(17). doi: 10.3390/app11177776.

Archana D, Dutta PK, Dutta J. Chitosan: A potential therapeutic dressing material for wound healing. Springer Series on Polymer and Composite Materials. 2016:193-227. doi: 10.1007/978-81-322-2511-9_8.

Islam S, Bhuiyan MAR, Islam MN. Chitin and chitosan: structure, properties and applications in biomedical engineering. J Polym Environ. 2017;25(3):854-66. doi: 10.1007/s10924-016-0865-5.

Kwon K. Chitin and chitosan derivatives: advances in drug discovery and developments. CRC Press/Taylor & Francis; 2014.

Tuwalska A, Grabska Zielinska S, Sionkowska A. Chitosan/Silk fibroin materials for biomedical applications-a review. Polymers (Basel). 2022;14(7). doi: 10.3390/polym14071343, PMID 35406217.

Feng P, Luo Y, Ke C, Qiu H, Wang W, Zhu Y. Chitosan-based functional materials for skin wound repair: mechanisms and applications. Front Bioeng Biotechnol. 2021;9:650598. doi: 10.3389/fbioe.2021.650598, PMID 33681176.

Sabab A, Vreugde S, Jukes A, Wormald PJ. The potential of chitosan-based haemostats for use in neurosurgical setting–literature review. J Clin Neurosci. 2021;94:128-34. doi: 10.1016/j.jocn.2021.10.018, PMID 34863426.

Pogorielov MV, Sikora VZ. Chitosan as a hemostatic agent: current state. Eur J Med Ser B. 2015;2:24-33. doi: 10.13187/ejm.s.b.2015.2.24.

Periayah MH, Halim AS, Yaacob NS, Saad AZ, Hussein AR, Rashid AH. Glycoprotein IIb/IIIa and P2Y12 induction by oligochitosan accelerates platelet aggregation. BioMed Res Int. 2014;2014:653149. doi: 10.1155/2014/653149, PMID 25247182.

Simoes SM, Rey Rico A, Concheiro A, Alvarez Lorenzo C. Supramolecular cyclodextrin-based drug nanocarriers. Chem Commun (Camb). 2015;51(29):6275-89. doi: 10.1039/C4CC10388B, PMID 25679097.

Bernkop Schnurch A. Strategies to overcome the polycation dilemma in drug delivery. Adv Drug Deliv Rev. 2018;136-137:62-72. doi: 10.1016/j.addr.2018.07.017. PMID 30059702.

Kassem A, Ayoub GM, Malaeb L. Antibacterial activity of chitosan nano-composites and carbon nanotubes: a review. Sci Total Environ. 2019;668:566-76. doi: 10.1016/j.scitotenv.2019.02.446, PMID 30856567.

Han G, Ceilley R. Chronic wound healing: a review of current management and treatments. Adv Ther. 2017;34(3):599-610. doi: 10.1007/s12325-017-0478-y, PMID 28108895.

Matica MA, Aachmann FL, Tøndervik A, Sletta H, Ostafe V. Chitosan as a wound dressing starting material: antimicrobial properties and mode of action. Int J Mol Sci. 2019;20(23):1-33. doi: 10.3390/ijms20235889, PMID 31771245.

Dash M, Chiellini F, Ottenbrite RM, Chiellini E. Chitosan-a versatile semi-synthetic polymer in biomedical applications. Prog Polym Sci. 2011;36(8):981-1014. doi: 10.1016/j.progpolymsci.2011.02.001.

Liu H, Wang C, Li C, Qin Y, Wang Z, Yang F. A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing. RSC Adv. 2018;8(14):7533-49. doi: 10.1039/c7ra13510f, PMID 35539132.

Shao W, Wu J, Wang S, Huang M, Liu X, Zhang R. Construction of silver sulfadiazine loaded chitosan composite sponges as potential wound dressings. Carbohydr Polym. 2017;157:1963-70. doi: 10.1016/j.carbpol.2016.11.087, PMID 27987918.

Wang L, Khor E, Wee A, Lim LY LL. Chitosan-alginate PEC membrane as a wound dressing: assessment of incisional wound healing. J Biomed Mater Res. 2002;63(5):610-8. doi: 10.1002/jbm.10382, PMID 12209908.

Wang X, Yu X, Yan Y, Zhang R ZR. Liver tissue responses to gelatin and gelatin/chitosan gels. J Biomed Mater Res A. 2008;87(1):62-8. doi: 10.1002/jbm.a.31712. PMID 18080311.

Dantas MDM, Cavalcante DRR, Araujo FEN. Improvement of dermal burn healing by combining sodium alginate/chitosan-based films and low-level laser therapy. J Photochem Photobiol B Biol. 2011;105(1):51-9. doi: 10.1016/j.jphotobiol.2011.06.009, PMID 21803596. doi: 10.1016/j.jphotobiol.2011.06.009.

Behera SS, Das U, Kumar A, Bissoyi A, Singh AK. Chitosan/TiO2 composite membrane improves proliferation and survival of L929 fibroblast cells: application in wound dressing and skin regeneration. Int J Biol Macromol. 2017;98:329-40. doi: 10.1016/j, PMID 28174079.

Lin WC, Lien CC, Yeh HJ, Yu CM, Hsu SH. Bacterial cellulose and bacterial cellulose-chitosan membranes for wound dressing applications. Carbohydr Polym. 2013;94(1):603-11. doi: 10.1016/j.carbpol.2013.01.076, PMID 23544580.

Anisha BS, Biswas R, Chennazhi KP, Jayakumar R. Chitosan-hyaluronic acid/nanosilver composite sponges for drug-resistant bacteria infected diabetic wounds. Int J Biol Macromol. 2013;62:310-20. doi: 10.1016/j.ijbiomac.2013. 09.011, PMID 24060281.

Zhang Y, Jiang M, Zhang Y, Cao Q, Wang X, Han Y. Novel lignin–chitosan–PVA composite hydrogel for wound dressing. Mater Sci Eng C Mater Biol Appl. 2019;104:110002. doi: 10.1016/j.msec.2019.110002. PMID 31499949.

Du X, Liu Y, Wang X, Yan H, Wang L, Qu L. Injectable hydrogel composed of hydrophobically modified chitosan/oxidized-dextran for wound healing. Mater Sci Eng C Mater Biol Appl. 2019;104:109930. doi: 10.1016/j.msec.2019.109930. PMID 31500069.

Cai ZX, Mo XM, Zhang KH, Fan LP, Yin AL, He CL. Fabrication of chitosan/silk fibroin composite nanofibers for wound-dressing applications. Int J Mol Sci. 2010;11(9):3529-39. doi: 10.3390/ijms11093529, PMID 20957110.

Diez Pascual AM, Diez Vicente AL. Wound healing bionanocomposites based on castor oil polymeric films reinforced with chitosan-modified ZnO nanoparticles. Biomacromolecules. 2015;16(9):2631-44. doi: 10.1021/acs.biomac.5b00447. PMID 26302315.

Rahimi M, Ahmadi R, Samadi Kafil H, Shafiei Irannejad V. A novel bioactive quaternized chitosan and its silver-containing nanocomposites as a potent antimicrobial wound dressing: structural and biological properties. Mater Sci Eng C Mater Biol Appl. 2019;101:360-9. doi: 10.1016/j.msec.2019.03.092, PMID 31029329.

Gao S, Jiang J, Li X, Ye F, Fu Y, Zhao L. Electrospun polymer-free nanofibers incorporating hydroxypropyl-β-cyclodextrin/ difenoconazole via supramolecular assembly for antifungal activity. J Agric Food Chem. 2021;69(21):5871-81. doi: 10.1021/acs.jafc.1c01351. PMID 34013730.

Published

26-11-2022

How to Cite

GOZALI, D., HUDAYA, A. R., & SUHARYANI, I. (2022). A REVIEW ON CHITOSAN-BASED MATERIALS AS POTENTIAL WOUND DRESSING MATERIALS. International Journal of Applied Pharmaceutics, 14(4), 27–32. https://doi.org/10.22159/ijap.2022.v14s4.PP23

Issue

Section

Review Article(s)

Most read articles by the same author(s)