• IKE SUSANTI Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia
  • NISA SAFITRI Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia
  • RIMADANI PRATIWI Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia
  • ALIYA NUR HASANAH Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia, Drug Development Study Center, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia



Salbutamol, Molecularly imprinted, Suspension polymerization, Separation


Objective: This study aims to determine the analytical performances and characteristics of MIP salbutamol made with methacrylic acid (MAA) monomer and trimethylpropane trimethacrylate (TRIM) cross-linker through suspension polymerization.

Methods: The MIP salbutamol was synthesized using suspension polymerization. The analytical performances of MIP, such as the adsorption ability, adsorption capacity and selectivity, were evaluated by Spectrophotometer UV-Vis. The physical characterization of MIP and NIP were evaluated using FTIR, TEM-EDS, Brunauer-Emmett-Teller (BET) method and Barret-Joyner-Halenda (BJH) method.

Results: Molecular Imprinted Polymer (MIP) showed better analytical performance than Non-Imprinted Polymer (NIP), the adsorption ability of MIP and NIP reached about 90.43% and 53.92%, respectively. The MIP was selective for salbutamol when compared to terbutaline and salmeterol xinafoate with an imprinting factor (IF) of 1.2841. The MIP has spherical shape particles with diameters in the range of 10-100 µm with a surface area of 185.546 m2/g, pore volume of 0.257 cm3/g, and pore size of 16.599 Å.

Conclusion: The Based on these results, MIP salbutamol, has the potential to be developed as a method for the preparation of salbutamol analysis from biological samples.


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