FELODIPINE-REVIEW OF ANALYTICAL METHODS DEVELOPED FOR PHARMACEUTICAL DOSAGE FORMS AND BIOLOGICAL FLUIDS

KIRAN MALLI; LALIT KUMAR; RUCHI VERMA

doi:10.22159/ijap.2023v15i6.49211

Authors

KIRAN MALLI Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, Udupi, Karnataka, India https://orcid.org/0009-0001-6419-4196
LALIT KUMAR Department of Pharmaceutics, National Institute of Pharmaceutical Education, Hajipur-844102, Vaishali, Bihar, India https://orcid.org/0000-0002-2418-9712
RUCHI VERMA Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, Udupi, Karnataka, India https://orcid.org/0000-0002-1279-7243

DOI:

https://doi.org/10.22159/ijap.2023v15i6.49211

Keywords:

Felodipine, Analytical methods, Pharmaceutical dosage forms, Biological fluids

Abstract

Felodipine (FDP) is a vascular selective L-type calcium channel blocker, in hypertension patients FDP significantly lowers systolic and diastolic blood pressure (BP). It is a lipophilic drug molecule that contains a dihydropyridine ring responsible to show pharmacological activity, it is mainly used to control and prevent essential hypertension. This review article provides a summary of various analytical techniques for determining felodipine in pure form, pharmaceutical formulations, and biological fluids. Various analytical techniques are developed and validated, such as ultraviolet/visible spectrophotometry, high-performance liquid chromatography (HPLC), high-performance thin layer chromatography (HPTLC), and bioanalytical techniques. Estimated validation parameters such as linearity, LOD (Limit of Detection), and LOQ (Limit of Quantification) are discussed for each method. The wavelength of detection (λmax), mobile phase, columns, flow rate, retention time (Rt) and sample preparation techniques are all important quality elements for calculating Felodipine via analytical procedures.

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Author Biography

LALIT KUMAR, Department of Pharmaceutics, National Institute of Pharmaceutical Education, Hajipur-844102, Vaishali, Bihar, India

Assistant Professor, Department of Pharmaceutics

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