LOZENGES FORMULATION OF CIPLUKAN (PHYSALIS ANGULATA L.) FRUIT EXTRACT AS AN ANTIOXIDANT WITH COMBINATION OF FILLER AGENTS AVICEL PH 102–LUDIPRESS

YENNI PUSPITA TANJUNG; TUBAGUS AKMAL; ANDI IKA JULIANTI; AMANINA FAUZIYYAH; APEP RIKI

doi:10.22159/ijap.2023.v15s2.14

Authors

YENNI PUSPITA TANJUNG Bumi Siliwangi Academy of Pharmacy, Bandung-40286, West Java, Indonesia https://orcid.org/0000-0002-1503-7856
TUBAGUS AKMAL Bumi Siliwangi Academy of Pharmacy, Bandung-40286, West Java, Indonesia
ANDI IKA JULIANTI Bumi Siliwangi Academy of Pharmacy, Bandung-40286, West Java, Indonesia https://orcid.org/0009-0007-5775-3395
AMANINA FAUZIYYAH Bumi Siliwangi Academy of Pharmacy, Bandung-40286, West Java, Indonesia https://orcid.org/0000-0002-1503-7856
APEP RIKI Bumi Siliwangi Academy of Pharmacy, Bandung-40286, West Java, Indonesia

DOI:

https://doi.org/10.22159/ijap.2023.v15s2.14

Keywords:

Ciplukan fruit extract, Lozenges, Avicel PH 102, Ludipress, Antioxidant

Abstract

Objective: This research aimed to determine the effect of variations in the concentration of filler agents Avicel PH 102-Ludipress on the evaluation results of granules and tablets and to determine the antioxidant activity of ciplukan (Physalis angulata L.) fruit extract lozenges.

Methods: The extract was obtained by the soxhletation method using ethanol 96%. The lozenges were made by direct compression, and the formula was divided into 3 concentration variations of Avicel PH 102 and Ludipress, namely F1 (1:2), F2 (1:1), and F3 (2:1). The best lozenges were tested for their antioxidant activity using the DPPH method.

Results: The results of statistical analysis using the One Way Anova test formulation of ciplukan fruit extract lozenges with variations in concentrations of Avicel PH 102 and Ludipress had a significant effect (p<0.05) on the angle of repose, bulk density, tapped density, Carr's index, Hausner's ratio, thickness, friability, and disintegration time, but no significant effect (p>0.05) on diameter, weight variation, and hardness. The best ciplukan fruit extract (F1) lozenge formula has a concentration ratio of Avicel PH 102 and Ludipress (1:2) with an IC50 value of 28.46 ppm and is classified as a very strong antioxidant.

Conclusion: Ciplukan fruit extract formulated in the form of lozenges with varying concentrations of the filler Avicel PH 102: Ludipress (1:2) has very strong antioxidant activity.

Downloads

Download data is not yet available.

References

Sumekar H. Pengaruh cara pengeringan terhadap kapasitas antioksidan ekstrak etanol daun dewandaru (Eugenia uniflora) dengan metode DPPH (1,1-difenil-2-pikrilhidrazil); 2019.

Larsen P, Ahmed M. Evaluation of antioxidant potential of honey drops and honey lozenges. Food Chem Adv. 2022;1:100013. doi: 10.1016/j.focha.2022.100013.

Fitriani DDWI, Kesehatan K, Indonesia R, Palembang PK, Farmasi J. Aktivitas antioksidan ekstrak asparagus (Asparagus officinalis L.) dengan Metode DPPH. Politeknik Kesehatan Palembang; 2019.

Nuranda A, Saleh C, Yusuf B. Potensi tumbuhan ciplukan (Physalis angulata Linn.) sebagai antioksidan alami. J At. 2016;01:5-9.

Celestino MT, Magalhães Ude O, Fraga AGM, do Carmo FA, Lione V, Castro HC. Rational use of antioxidants in solid oral pharmaceutical preparations. Braz J Pharm Sci. 2012;48:405-15. doi: 10.1590/S1984-82502012000300007.

Departemen kesehatan republik Indonesia. Farmakope Indoesia Edisi; 2020.

Sulaiman TNS, Sulaiman S. Excipients for tablet manufacturing with direct compression method. J Pharm Sci. 2020;3:64-76.

Budaya UD, Hazael A. Avicel PH 102 and manitol concentration variations on physical characters of suction tablets of Ekinase root extract (Echinacea purpurea (Herb.)) in direct compress; 2018;3:1-14.

Da Gama SKJ. J Jamu Kusuma. Comparison method of extraction to total flavonoid convention of 70% ethanol extract of gaharu leaves (Aquilaria microcarpa Baill.); 2021. p. 51-6. doi: 10.37341/jurnaljamukusuma.v1i2.11.

Bansal M, Gulati M, Singh SK, Duggal S. Antibacterial, antitussive, antioxidant and toxicological evaluation of Joshanda lozenges. J App Pharm Sci. 2015;5:64-70. doi: 10.7324/JAPS.2015.50711.

Putri YD, Tristiyanti D, Teresia M. Formulasi dan evaluasi tablet hisap Triamsinolon Asetonida dengan variasi Pengikat Maltodekstrin dan pvp. JSTFI. 2018;7(2):1-12. doi: 10.58327/jstfi.v7i2.76.

Raykar M, Velraj M. Design, development and evaluation of mouth dissolving tablets of tofacitinib citrate. Int J App Pharm. 2022;14:238-45. doi: 10.22159/ijap.2022v14i1.42810.

Shrivastav S, Rathore KS, Prasad N. Formulation and evaluation of dispersible tablets of flavonoid Pgal isolated from Saraca Asoca leaves. Int J App Pharm. 2023;15:125-30. doi: 10.22159/ijap.2023v15i4.47855.

Kumar I, Chaudhary D, Thakur B, Pandit V. Formulation and evaluation of piroxicam fast dissolving tablets using direct compression and sublimation method. J Drug Delivery Ther 2020;10(3-s):17-25. doi: 10.22270/jddt.v10i3-s.4063.

Thoke SB, Sharma YP, Rawat SS, Nangude SL. Formulation development and evaluation of effervescent tablet of alendronate sodium with vitamin D3. J Drug Deliv Ther. 2013;3:65-74. doi: 10.22270/jddt.v3i5.623.

Shanmugam S, Senthil D, Ventrichelvan T. Formulation and evaluation of loratadine mouth dissolving tablet. Bangladesh J Sci Ind Res. 2013;48(2):137-42. doi: 10.3329/bjsir.v48i2.15745.

Raheem A, Singh R, Hiremath A, Nayak N, Kamath KSS. Formulation and comparative evaluation of ondansetron hydrochloride mouth dissolving tablets in India. Int J Pharm Pharm Sci. 2019;11(9):57-64. doi: 10.22159/ijpps.2019v11i9.33840.

Anand B, Thomas I, Elessey Abraham BP. Formulation and evaluation of herbal lozenges containing eucalyptus oil and coleus aromaticus oil. Am J PharmTech Res. 2018;8:316-22. doi: 10.46624/ajptr.2018.

Astuti S, Ekstrak Kloroform UAA, Daun. Uji akt antioksidan ekstrak kloroform daun tomat (Solanum Lycopersicum L.), daun cabai merah (Capsicum Annu L) dan daun ciplukan (Physalis angulata L.) dengan metod dpph; 2016.

Najihudin A, Nuari DA, Caroline D, Sriarumtias FP. Formulasi dan evaluasi tablet hisap ekstrak etanol daun cincau hijau (Premna oblongata Miq) sebagai antioksidan. Fitofarmaka JIF 2021;11(1):76-86. doi: 10.33751/jf.v11i1.2665.

Tanjung Yp, Julianti Ai, Isnayanti I RA. Formulation and evaluation of peel off gel facial mask from arabica coffee fruit peel extract (Coffea arabica L.). Int J Appl Pharm. 2021;13:148-51. doi: 10.22159/ijap.2021.v13s4.43845.

Budiman A, Zelika MR, Nadiatul KY, Aulifa DL. Peel-off mask formulation from black mulberries (Morus nigra L.) leaves extract as a tyrosinase inhibitor. Int J Drug Deliv Technol. 2019;9:525-9. doi: 10.25258/ijddt.v9i4.3.

Raj AR, KN. Formulation and evaluation of meloxicam crystals using spherical crystallization for solubility enhancement. Res Rev A J Drug Formul Dev Prod. Com. 2016;3:15-35.

Rifani FA. Optimasi formula fast disintegrating tablet (FDT) metoklopramid HCl dengan superdisintefrant sodium starch glycolate dan filler-binder ludipress dengan metode simplex lattice design. Progress in retinal and eye research. Universitas Setia Budi Surakarta; 2019.

Moghbel A, Abbaspour H. Study of compressibility properties of yogurt powder in order to prepare a complementary formulation. Iran J Pharm Res. 2013;12(3):231-7. PMID 24250628.

Barde L, Suruse P, Agrawal S, Kalkotwar R, Sable V, Tare H. Design, development and fabrication of mouth-dissolving tablets containing extract of Tribulus terrestris for the treatment of hypertension. Int J App Pharm. 2023;15:234-41. doi: 10.22159/ijap.2023v15i3.47662.

Handayani R, Auliasari N, Hasanah HU, Farmasi D. Formulasi dan evaluasi sediaan tablet hisap dari ekstrak etanol biji kopi arabika (Coffea arabica l.) java preanger sebagai antioksidan. J Ilm Manuntung. 2022;8(1):82-8. doi: 10.51352/jim.v8i1.496.

Elkhodairy KA, Hassan MA, Afifi SA. Formulation and optimization of orodispersible tablets of flutamide. Saudi Pharm J. 2014;22(1):53-61. doi: 10.1016/j.jsps.2013.01.009, PMID 24493974.

Molyneux P. The use of the stable free radical diphenylpicryl-hydrazyl (DPPH) for estimating antioxidant activity. Songklanakarin J Sci Technol. 2004;26:211-9.