EFFECTIVENESS OF CORK FISH EXTRACT GEL ON FIBROBLAST PROLIFERATION IN SOCKET WOUND AFTER TOOTH EXTRACTION

OLIVIA AVRIYANTI HANAFIAH; DENNY SATRIA; ZAFIRA ALFAN MADHY; NURINZIVA ZAHRA WARDHANI; AFIFAH AYUNI H. G.; TASYFINA HANNAN FAJAR; M. YUDHA ABDILLAH LUBIS; MUHAMMAD RASYAD AKRAMSYAH

doi:10.22159/ijap.2024.v16s2.08

Authors

OLIVIA AVRIYANTI HANAFIAH Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Universitas Sumatera Utara, Medan, North Sumatra, Indonesia
DENNY SATRIA Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, North Sumatra, Indonesia
ZAFIRA ALFAN MADHY Faculty of Dentistry, Universitas Sumatera Utara, Medan, North Sumatra, Indonesia https://orcid.org/0009-0009-3206-394X
NURINZIVA ZAHRA WARDHANI Faculty of Dentistry, Universitas Sumatera Utara, Medan, North Sumatra, Indonesia https://orcid.org/0009-0009-5632-688X
AFIFAH AYUNI H. G. Postgraduate Student, Faculty of Dentistry, Universitas Sumatera Utara, Medan, North Sumatra, Indonesia
TASYFINA HANNAN FAJAR Faculty of Dentistry, Universitas Sumatera Utara, Medan, North Sumatra, Indonesia https://orcid.org/0009-0004-9364-7467
M. YUDHA ABDILLAH LUBIS Faculty of Dentistry, Universitas Sumatera Utara, Medan, North Sumatra, Indonesia https://orcid.org/0009-0000-1586-1565
MUHAMMAD RASYAD AKRAMSYAH Faculty of Dentistry, Universitas Sumatera Utara, Medan, North Sumatra, Indonesia https://orcid.org/0009-0001-8310-0597

DOI:

https://doi.org/10.22159/ijap.2024.v16s2.08

Keywords:

Cork fish extract, Wound healing, Tooth extraction, Fibroblasts

Abstract

Objective: Socket wound healing involves soft tissue cells that play an important role, namely fibroblasts. In the wound-healing process, proteins are needed that can accelerate wound healing, one of which is albumin. Cork fish contains the highest albumin than other fish. Albumin contains natural proteins and collagen that make up the extracellular matrix, which has the role of inducing growth factors, cell migration and adhesion, and tissue regeneration. The purpose of this study was to examine the effect of 1%, 3%, 5% and 7% cork fish extract gel on fibroblast cell proliferation in socket wound healing after tooth extraction.

Methods: This study was a laboratory experimental study with 30 Wistar rats that were grouped into 5 groups. The treatment group was given cork fish extract gel, namely 1%, 3%, 5% and 7%, and the negative control group was only given base gel was then the tissue was tested using Hematoxylin Eosin to observe fibroblasts on the 3^rd, 7^th and 14^th day.

Results: Based on the results of the one-way ANOVA test, it showed that cork fish extract with a concentration of 1%, 3%, 5% and 7% has an effect on fibroblast proliferation in socket wound healing after tooth extraction.

Conclusion: Based on the results of the one-way ANOVA test, it showed that 3% cork fish extract had an influence on fibroblast proliferation in healing socket wounds after tooth extraction.

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