NATURAL FLAVONOIDS: A NOVEL APPROACH TO BREAST CANCER (REVIEW)
Abstract
Cancer is a hereditary disease and is caused due to the abnormal growth of the cells. Cancer can be of many forms but the most prevalent is the breast cancer. Breast cancer is the most common among women and can be treated by radiation therapy, surgery, hormone therapy, chemotherapy and natural therapy. The present review presents an overview about the role of flavonoids in curing cancer. This review gives a detailed account of classification of flavonoids. The in vivo and in vitro studies show the action of flavonoids on cancer. Various natural flavonoids can be extracted and can be used for various therapeutic effects apart from cancer.
Keywords: Flavanoids , Cancer, Breast Cancer, Classification of flavanoids
References
Cancer; Malcolm R Alison, Imperial College School of Medicine, London, UK. ENCYCLOPEDIA OF LIFE SCIENCES / & 2001 Nature Publishing Group / www.els.net.
Breast Cancer and the Environment A Life Course Approach, http://iom.nationalacademies.org/~/media/Files/Report%20Files/2011/Breast-Cancer-Environment/breastcancerreportbrief_2.pdf
Breast Cancer Treatment Options: Surgery and Radiation Therapy: A Literature Review. Breast cancer treatment options: a literarure review, December 2012
Effects of Flavonoids on Prolferation of Breast Cancer Cells and Vascular Smooth Muscle Cells Liu Po Shiu Jackie, A thesis submitted for the degree of Master of Medical Sciences (2007), THE UNIVERSITY OF HONG KONG.
Http://files.rushim.ru/books/mechanizms/the-science-of-flavonoids.pdf
The Science of Flavonoids, THE STEREOCHEMISTRY OF FLAVONOIDS, Jannie P.J. Marais, Bettina Deavours, Richard A. Dixon, and Daneel Ferriera. Springer, ISBN-13: 978-0387-28821-5, 2006 Springer Science Business Media, Inc.
Middleton EJ, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease and cancer. Pharmacol Rev. 2000;52:673–751.Pubmed
Galati G, Teng S, Moridani MY, Chan TS, O Brien PJ. Cancer chemoprevention and apoptosis mechanisms induced by dietary polyphenolics. Drug Metabol Drug Interact. 2000;17:311–49. Pubmed
Yang CS, Landau JM, Huang MT, Newmark HL. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu Rev Nutr. 2001;21:381–406. Pubmed
Birt DF, Hendrich S, Wang W. Dietary agents in cancer prevention Flavonoids and isoflavonoids.Pharmacol Ther. 2001; 90:157–77. Pubmed
Flavonoids: A versatile source of anticancer drugs, Maheep K Chahar, Neelu Sharma, Mahabeer P Dobhal, Yogesh C Joshi , Review Article , Year : 2011 ,Volume : 5,Issue : 9, Page : 1-12. DOI: 10.4103/0973-7847.79093. PMC
Pourmorad F, Hosseinimehr SJ, Shahabimajd N. Antioxidant activity, phenol and flavonoid contents of some selected Iranian medicinal plants. The African Journal of Biotechnology. 2006;5(11):1142–1145.
Kumar S, Pandey AK. Antioxidant, lipo-protective and antibacterial activities of phytoconstituents present in Solanum xanthocarpum root. International Review of Biophysical Chemistry. 2012;3(3):42–47.
Mignet N, Seguin J, Ramos Romano M, Brulle L, Touil YS, Scherman D, et al. Development of a liposomal formulation of the natural flavonoid fisetin. Int J Pharm.2012;423:69–76. Pubmed
Kim JH, Jung CH, Jang BH, Go HY, Park JH, Choi YK, et al. Selective cytotoxic effects on human cancer cell lines of phenolic-rich ethyl-acetate fraction from Rhus verniciflua Stokes.Am J Chin Med. 2009;37:609–20.Pubmed
Li YL, Gan GP, Zhang HZ, Wu HZ, Li CL, Huang YP, et al. A flavonoid glycoside isolated from Smilax china L. Rhizome in vitro anticancer effects on human cancer cell lines. J Ethnopharmacol. 2007;113:115–24. Pubmed
Attoub S, Hassan AH, Vanhoecke B, Iratni R, Takahashi T, Gaben AM, et al. Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells. Eur J Pharmacol. 2011;651:18–25. Pubmed
Total Phenolics and Total Flavonoids in Selected Indian Medicinal Plants, C. T. Sulaiman* and Indira Balachandran , Indian J Pharm Sci. 2012 May-Jun; 74(3): 258–260.PMC.
Lopez M, Martinez F, Del Valle C, Orte C, Miro M. Analysis of phenolic constituents of biological interest in red wines by high-performance liquid chromatography. Journal of Chromatography A.2001;922(1-2):359–363. [pubmed]
Hara Y, Luo SJ, Wickremasinghe RL, Yamanishi T. Special issue on tea. Food Reviews International.1995;11:371–542.
Kreft S, Knapp M, Kreft I. Extraction of rutin from buckwheat (Fagopyrum esculentum Moench) seeds and determination by capillary electrophoresis. Journal of Agricultural and Food Chemistry.1999;47(11):4649–4652. [pubmed]
Stewart AJ, Bozonnet S, Mullen W, Jenkins GI, Lean ME, Crozier A. Occurrence of flavonols in tomatoes and tomato-based products. Journal of Agricultural and Food Chemistry. 2000;48(7):2663–2669.[pubmed]
Hertog MGL, Hollman PCH, Katan MB. Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. Journal of Agricultural and Food Chemistry. 1992;40(12):2379–2383.
Miyake Y, Shimoi K, Kumazawa S, Yamamoto K, Kinae N, Osawa T. Identification and antioxidant activity of flavonoid metabolites in plasma and urine of eriocitrin-treated rats. Journal of Agricultural and Food Chemistry. 2000;48(8):3217–3224. [pubmed]
. Rousseff RL, Martin SF, Youtsey CO. Quantitative survey of narirutin, naringin, hesperidin, and neohesperidin in citrus. Journal of Agricultural and Food Chemistry. 1987;35(6):1027–1030.
Reinli K, Block G. Phytoestrogen content of foods: a compendium of literature values. Nutrition and Cancer. 1996;26(2):123–148. [pubmed]
Plant Phytochemicals as Epigenetic Modulators: Role in Cancer Chemoprevention, Vijay S. Thakur, Gauri Deb, Melissa A. Babcook, and Sanjay Gupta ,AAPS J. 2014 Jan; 16(1): 151–163.PMC
Kunnumakkara AB, Anand P, Aggarwal BB. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett.2008;269:199–225. [pubmed]
Multi-targeted prevention of cancer by sulforaphane (review).,Clarke JD, Dashwood RH, Ho E Cancer Lett. 2008 Oct 8; 269(2):291-304.[pubmed]
Banerjee S, Kong D, Wang Z, Bao B, Hillman GG, Sarkar FH. Attenuation of multi-targeted proliferation-linked signaling by 3,30-diindolylmethane (DIM): from bench to clinic. Mutat Res.2011;728:47–66. [PMC free article] [pubmed]
Multi-targeted therapy of cancer by genistein (review). Banerjee S, Li Y, Wang Z, Sarkar FH Cancer Lett. 2008 Oct 8; 269(2):226-42. [pubmed]
Review, Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention. Cheung KL, Kong AN AAPS J. 2010 Mar; 12(1):87-97(PUBMED)
Resveratrol and cancer: a review.Savouret JF, Quesne M Biomed Pharmacother. 2002 Mar; 56(2):84-7 .(PMC)
Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. Giovannucci E J Natl Cancer Inst. 1999 Feb 17; 91(4):317-31.(Pubmed)
Wine, alcohol, platelets, and the French paradox for coronary heart disease. Renaud S, de Lorgeril M Lancet. 1992 Jun 20; 339(8808):1523-6 pubmed.
Flavonoids: a review of probable mechanisms of action and potential applications. Nijveldt RJ, van Nood E, van Hoorn DE, Boelens PG, van Norren K, van Leeuwen PA Am J Clin Nutr. 2001 Oct; 74(4):418-25. (pubmed)
Anti-helicobacter pylori flavonoids from licorice extract. Fukai T, Marumo A, Kaitou K, Kanda T, Terada S, Nomura T.. Life Sci 2002; 71:1449–1463.
Http://www.allcancerguide.com/2015/07/flavonoids-in-breast-cancer.html
Http://dmd.aspetjournals.org/content/33/3/341.full
Breast Cancer and Flavonoids - A Role in Prevention. Hitomi Takemura, Hiroyuki Sakakibara, Shunsuke Yamazaki and Kayoko Shimoi Current Pharmaceutical Design, 19(34):6125-6132.
Flavonoid intake and breast cancer risk: a case–control study in Greece. J Peterson et.al Br J Cancer. 2003 Oct 6; 89(7): 1255–1259.
Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells. Hirano T, Gotoh M, Oka K. Life Sci 1994;55:1061–1069.
Cytotoxicities of some flavonoid analogues. Cushman M, Nagarathnam D. J Nat Prod 1991;54:1656– 1660.
Inhibitory effects of bifidobacterium-fermented soy milk on 2-amino-1-methyl-6-phenylimidaz [4,5-b]pyridine-induced rat mammary carcinogenesis, with a partial contribution of its component isoflavones. Ohta T, Nakatsugi S, Watanabe K, Kawamori T, Ishikawa F, Morotomi M, Sugie S, Toda T, Sugimura T, Wakabayashi K Carcinogenesis 2000;21:937–941.
Anti-cancer potential of flavonoids: recent trends and future perspectives. Priya Batra• Anil K. Sharma. Review,3 Biotech(2013),3:439-459.