• YESI DESMIATY Faculty of Pharmacy, Pancasila University, Jakarta, Indonesia
  • BERNA ELYA Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia




Raspberry, Nutricosmetics, Anti-wrinkle, DPPH, Soxhlet extraction


Objective: This research aimed to examine the anti-oxidant activity, antielastase activity, and the content of total phenolic and total flavonoid of R. fraxinifolius unripe fruit.

Methods: The dried unripe fruit was extracted using Soxhlet apparatus with sequence solvent: n-hexane, ethyl acetate, and methanol. Each extract was determined the anti-oxidant and antielastase activity, total phenolic, and total flavonoid content.

Result: The result showed the extracts (n-hexane, ethyl acetate, and methanol) gave anti-oxidant IC50>200; 186.84; and 19.74 ppm, and the ability of elastase inhibition was 6.84+0.9%; 52.23+7.1%; and 57.81+5.5% at 100 ppm, respectively. The methanolic extract contained phenolic 202.2 mg GAE/g extract and flavonoid 43.89 mg QE/g extract.

Conclusion: R. fraxinifolius unripe fruit has shown potential as a DPPH (α, α-diphenyl-β-picrylhydrazyl) radical scavenger and anti-elastase. This study provides an excellent effect to underline the importance of R. fraxinifolius unripe fruit, and it can be developed as nutricosmetics, nutraceuticals, or herbal anti-wrinkle cosmetics.


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How to Cite

DESMIATY, Y., & ELYA, B. (2021). UNRIPE FRUIT OF RUBUS FRAXINIFOLIUS AS A POTENTIAL SOURCE OF ANTIOXIDANT AND ANTIELASTASE AGENT. International Journal of Applied Pharmaceutics, 13(2), 78–81. https://doi.org/10.22159/ijap.2021.v13s2.15



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