FORMULATIONS AND CHARACTERIZATIONS OF TELANG FLOWER EXTRACT (CLITORIA TERNATEA L.) GEL USING HYDROXY PROPYL METHYL CELLULOSE (HPMC) AS GELLING AGENT AND ITS ANTIOXIDANT ACTIVITY

SETYO NURWAINI; ARUNIYAL ALIMATUS SADIAH; RIZA MAULANA; TEGUH IMANTO

doi:10.22159/ijap.2024.v16s6.SE2030

Authors

SETYO NURWAINI Pharmaceutic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy Universitas Muhammadiyah Surakarta Jl Ahmad Yani Kartasura, Surakarta, Indonesia https://orcid.org/0000-0002-3166-7348
ARUNIYAL ALIMATUS SADIAH Pharmaceutic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy Universitas Muhammadiyah Surakarta Jl Ahmad Yani Kartasura, Surakarta, Indonesia
RIZA MAULANA Pharmaceutic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy Universitas Muhammadiyah Surakarta Jl Ahmad Yani Kartasura, Surakarta, Indonesia https://orcid.org/0009-0000-9491-3262
TEGUH IMANTO Pharmaceutic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy Universitas Muhammadiyah Surakarta Jl Ahmad Yani Kartasura, Surakarta, Indonesia

DOI:

https://doi.org/10.22159/ijap.2024.v16s6.SE2030

Keywords:

Telang flowers extract, HPMC, Antioxidant

Abstract

Objective: Telang flowers (Clitoria ternatea L.) are plants that contain a natural source of antioxidants that can be formulated in gel preparation with a variation of concentration of gelling agent Hydroxy Propyl Methyl Cellulose (HPMC). The purpose of this research was to know the difference in the levels of HPMC as a gelling agent against the physical properties and antioxidant activity of preparation of telang flower extract gel.

Methods: The extraction of telang flowers is done by a maceration method with a 96% ethanol solvent. The gel was formulated with HPMC concentration variations of 2%, 2.5% and 3% respectively. The physical properties of the gel that were determined were organoleptic, pH, stickiness, spreadability, viscosity, and homogeneity. Antioxidant activity was determined using DPPH (2,2-diphenyl-1-picrylhydrazyl). Data was analyzed statistically using a one-way ANOVA test with a 95% confidence level.

Results: The results of the research showed that the best formula was formula II with a concentration of HPMC of 2.5%. The gel of extract telang flower has characteristics with a typical scent of the telang flower, the blue-purple color, homogeneous, pH was 6.393±0.01, stickiness was 1.203±0.7 s, spreadability was 4.17±0.1 cm, and viscosity was 3000±100 cP. The antioxidant activity (IC₅₀) the gel was 101.42 ppm belongs to the category of moderate antioxidants.

Conclusion: Gel extract of telang flowers with concentration gelling agent HPMC concentration of 2.5% had the best physical properties.

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