FORMULATION AND EVALUATION OF SODIUM DICLOFENAC SLOW-RELEASE TABLET USING A COMBINATION OF MANGROVE FRUIT STARCH (BRUGUIERA GYMNORRHIZA) AND SODIUM CARBOXY METHYL CELLULOSE (CMC) AS MATRIX

SETYO NURWAINI; ANITA FITRI ANGGRAINI; ANITA SUKMAWATI; TEGUH IMANTO; WAHYU UTAMI

doi:10.22159/ijap.2024.v16s6.52795

Authors

SETYO NURWAINI Pharmaceutic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy Universitas Muhammadiyah Surakarta Jl Ahmad Yani Kartasura, Surakarta, Indonesia https://orcid.org/0000-0002-3166-7348
ANITA FITRI ANGGRAINI Pharmaceutic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy Universitas Muhammadiyah Surakarta Jl Ahmad Yani Kartasura, Surakarta, Indonesia
ANITA SUKMAWATI Pharmaceutic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy Universitas Muhammadiyah Surakarta Jl Ahmad Yani Kartasura, Surakarta, Indonesia https://orcid.org/0000-0002-9438-955X
TEGUH IMANTO FORMULATION AND EVALUATION OF SODIUM DICLOFENAC SLOW-RELEASE TABLET USING A COMBINATION OF MANGROVE FRUIT STARCH (BRUGUIERA GYMNORRHIZA) AND SODIUM CARBOXY METHYL CELLULOSE (CMC) AS MATRIX https://orcid.org/0000-0002-6171-925X
WAHYU UTAMI Pharmaceutical chemistry laboratory, Faculty of Pharmacy Universitas Muhammadiyah Surakarta Jl Ahmad Yani Kartasura, Surakarta, Indonesia https://orcid.org/0000-0002-3156-3645

DOI:

https://doi.org/10.22159/ijap.2024.v16s6.52795

Keywords:

Mangrove fruit starch (Bruguiera gymnorrhiza), CMC, Sodium diclofenac, Optimization, Simplex lattice design

Abstract

Objective: Mangrove fruit (Bruguiera gymnorrhiza) has a high starch content that potential as a matrix for slow-release tablets. This study aims to determine the optimum formula for diclofenac sodium tablets using a matrix combination of mangrove fruit starch and sodium Carboxy Methyl Cellulose (CMC).

Methods: Optimization of the formula was carried out using the Simplex Lattice Design method. Evaluation of the tablet includes the physical properties of the granules, tablet, and dissolution profile.

Results: The combination of mangrove fruit starch of 15-45% and 0-30% CMC fulfilled the requirements for granule flow properties and the release of active substances. The optimum formula obtained was a combination of mangrove fruit starch 32.30% (193.80 mg) and 12.70% Na-CMC (76.20 mg) with a desirability value of 0.805.

Conclusion: The results of this study clearly showed that the combination of mangrove starch and CMC was successfully used in the slow-release tablet formulation of diclofenac sodium

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References

Wikantyasning ER, Setiyadi G, Pramuningtyas R, Kurniawati MD, Ho CY. Formulation of nanoemulgel containing extract of Impatients balsamina L. and its antibacterial activity. International Journal of Applied Pharmaceutics. 2023; 15(3), 67–70. https://doi.org/10.22159/ijap.2023v15i3.46670

Jacoeb AM, Nugraha R, Putu S, and Dia S. Production of edible film from lindur fruit starch with the addition of glycerol and carageenan. Jphpi. 2014; vol 17, 14–21.

Amin MN, Pralebda S, Hasan M, Zakariya Z, Subekti S, Saputra E, Andriyono S, Pramono H, and Alamsjah M. Physicochemical properties of (Bruguiera gymnorrhiza) flour (BGF). International Food Research Journal. 2018; 25 (October); 1852–1857.

Afandi I, Siagian II, and Putri RC. Formulation design of mangrove sonneratia caseolaris fruit powder as a disintegrant in paracetamol tablet formulations. Jurnal Seminar Nasional Kelautan XIII. 2018; p33–38.

Talib A, Tamrin A, and Deni S. Study about potential fruit mangrove as a food alternative in the future. International Journal of Agronomy and Tropical Plants. 2018; 1–8.

Pawar H, Varkhade C, Jadhav P, Mehra K. Development and evaluation orodispersible tablets using a natural polysaccharide isolated from Cassia toraseeds. Integr Med Res. 2014;3(2):91-8.

Ameen MSM, Ibrahim, NJ, & Omar, TA. Design and evaluation of sustained release bilayer tablets of oxcarbazepine. J Pharm Innov. 2023. https://doi.org/10.1007/s12247-022-09694-2

Quinten T, De Beer T, Onofre FO, Mendez-Montealvo G, Wang YJ, Remon JP, Vervaet C. Sustained-release and swelling characteristics of xanthan gum/ethylcellulose-based injection moulded matrix tablets: in vitro and in vivo evaluation. J Pharm Sci. 2011 Jul;100(7):2858-70. doi: 10.1002/jps.22480. Epub 2011 Jan 19. PMID: 21254067.

Nurwaini S, Yuliani R, Jannah W, Sinaka A, Yulistyanti DU. Formulation and antibacterial activity of Ceremai (Phyllanthus acidus) lozenges using three different binders. International Journal of Pharmaceutical Research. 2020 Jan-March; 12(1):485-489

Sirisolla J, Ramanamurthy KV. Formulation and Evaluation of Cefixime Trihydrate Matrix Tablets Using HPMC, Sodium CMC, Ethyl Cellulose. Indian J Pharm Sci. 2015 May-Jun;77(3):321-7. doi: 10.4103/0250-474x.159663

Varghese N, Komala M. Analysis of in vitro disintegration and dissolution effect of Cucurbita maxima starch in losartan FDT. Int J App Pharm. 2022 Jul 7;14(4):163-70. https://innovareacademics.in/journals/index.php/ijap/article/view/43852

Ministry of Health of the Republic of Indonesia. Indonesian Pharmacopoeia Edition VI, Ministry of Health of the Republic of Indonesia. Jakarta; 2020

Sulistyawati, Wignyanto, and Kumalaningsih S. Low tannins and HCN of lindur fruit flour products as an alternative food. Jurnal Teknologi Pertanian. 2012; 13(3), 187–198.

Rowe RC, Sheskey PJ, Owen SC. Handbook of Pharmaceutical Excipients. Pharmaceutical Press; 2006

Swastawati F, Surti T, Agustini TW, and Riyadi PH. Quality Characteristics of Smoked Fish Processed Using Different Methods and Types of Fish, Jurnal Aplikasi Teknologi Pangan. 2013; 2 (3), 1–7

Burhan L, Yamlean PVY, and Supriati HS. Formulation of effervescent granules of soursop fruit juice (Annona muricata L). Pharmacon. 2012; 1 (2), 72–78.

Lachman L, Lieberman HA. and Kanig JL. The Theory and Practice of Industrial Pharmacy By Lachman and Lieberman (3Rd Edition); 1986

Sari NI. Optimization of red cabbage extract ethanol tablet formula (Brassica oleracea var. Capitata l.) with CMC sod binder and methyl cellulose disintegrating material using the simplex lattice design method. Thesis. Muhammadiyah University Surakarta; 2017

Suprapto S, and Setiyadi S. Formulation of theophylline sustained release matrix tablets: optimization study of the effect of compression pressure and ethylcellulose matrix and HPMC with a factorial design model. Journal of Science & Technology Research. 2010; 2 :100-116.

Alita, G. S. and Suprapto, S. Optimization of captopril slow-release tablets using PVP as a binder and talc-magnesium stearate as a lubricant using the simplex lattice design method. Usadha Journal of Pharmacy. 2023; 2(1), 86–107. https://doi.org/10.1234/ujp.v2i1.121

Herzanti, A. and Suprapto, S. Optimization of captopril slow-release tablets using gelatin as a binding agent and talc-magnesium stearate as a lubricating agent with the simplex lattice design method. Usadha Journal of Pharmacy. 2023; 2(2), 218–235. https://doi.org/10.1234/ujp.v2i2.148

Widhiardani FAF, and Setiyadi G. Optimization of glycerol as a humectant and HPMC as a geling agent in the antioxidant gel formula of carrot extract (Daucus carota L.). Usadha Journal of Pharmacy. 2023;2(3):278–290. https://doi.org/10.23917/ujp.v2i3.86