FORMULATION AND EVALUATION OF SODIUM DICLOFENAC SLOW-RELEASE TABLET USING A COMBINATION OF MANGROVE FRUIT STARCH (BRUGUIERA GYMNORRHIZA) AND SODIUM CARBOXY METHYL CELLULOSE (CMC) AS MATRIX

SETYO NURWAINI; ANITA FITRI ANGGRAINI; ANITA SUKMAWATI; TEGUH IMANTO; WAHYU UTAMI

doi:10.22159/ijap.2024.v16s6.TY2040

Authors

SETYO NURWAINI Pharmaceutic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy Universitas Muhammadiyah Surakarta Jl Ahmad Yani Kartasura, Surakarta, Indonesia https://orcid.org/0000-0002-3166-7348
ANITA FITRI ANGGRAINI Pharmaceutic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy Universitas Muhammadiyah Surakarta Jl Ahmad Yani Kartasura, Surakarta, Indonesia
ANITA SUKMAWATI Pharmaceutic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy Universitas Muhammadiyah Surakarta Jl Ahmad Yani Kartasura, Surakarta, Indonesia https://orcid.org/0000-0002-9438-955X
TEGUH IMANTO Pharmaceutic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy Universitas Muhammadiyah Surakarta Jl Ahmad Yani Kartasura, Surakarta, Indonesia https://orcid.org/0000-0002-6171-925X
WAHYU UTAMI Pharmaceutical chemistry laboratory, Faculty of Pharmacy Universitas Muhammadiyah Surakarta Jl Ahmad Yani Kartasura, Surakarta, Indonesia https://orcid.org/0000-0002-3156-3645

DOI:

https://doi.org/10.22159/ijap.2024.v16s6.TY2040

Keywords:

Mangrove fruit starch (Bruguiera gymnorrhiza), CMC, Sodium diclofenac, Optimization, Simplex lattice design

Abstract

Objective: Mangrove fruit (Bruguiera gymnorrhiza) has a high starch content that potential as a matrix for slow-release tablets. This study aims to determine the optimum formula for diclofenac sodium tablets using a matrix combination of mangrove fruit starch and sodium Carboxy Methyl Cellulose (CMC).

Methods: Optimization of the formula was carried out using the Simplex Lattice Design method. Evaluation of the tablet includes the physical properties of the granules, tablet, and dissolution profile.

Results: The combination of mangrove fruit starch of 15-45% and 0-30% CMC fulfilled the requirements for granule flow properties and the release of active substances. The optimum formula obtained was a combination of mangrove fruit starch 32.30% (193.80 mg) and 12.70% Na-CMC (76.20 mg) with a desirability value of 0.805.

Conclusion: The results of this study clearly showed that the combination of mangrove starch and CMC was successfully used in the slow-release tablet formulation of diclofenac sodium

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