3D PRINTING FOR THE FUTURE OF PHARMACEUTICALS DOSAGES FORMS

Authors

  • Monisha Bansal University School of Pharmaceutical Sciences, Rayat Bahra University, Saharuan, Kharar, Mohali, Punjab, 140104 India
  • Varun Sharma University School of Pharmaceutical Sciences, Rayat Bahra University, Saharuan, Kharar, Mohali, Punjab, 140104 India
  • Gurfateh Singh University School of Pharmaceutical Sciences, Rayat Bahra University, Saharuan, Kharar, Mohali, Punjab, 140104 India
  • S. L. Harikumar

DOI:

https://doi.org/10.22159/ijap.2018v10i3.25024

Keywords:

3D, Computer aided design, FDM, Spritam, FDA

Abstract

With the rapid pace of development in industrial sector, the pharma sector and researchers involved are equally contributing in developing the latest technology for the growth and development. The computer-aided designs and manufacturing that provides 3 Dimensional printed dosage forms is the new step being taken into consideration. With the FDA approval to first 3D printed tablet in August 2015, Spritam, 3 Dimensional printing (3DP) has become the all new method for preparation of drug delivery system. 3D printing has the capability of dispensing the drug more accurately, precisely, and the layer by layer assembly helps in forming complex composition and geometries. 3D printing enables the preparation of personalised dosage form and tailored release profiles. 3D printing can be seen as future of solid dosage forms produced on demand, with customised dose and possibly lower in cost. It can help in reducing side effects caused by excessive doses. This review highlights the 3D printing technology and its applications in growth of pharmaceutical sector. An overview of reviews was conducted to locate published literature between 2000 and 2017.

Downloads

Download data is not yet available.

References

Wohlers TT, Caffrey T. Wohlers report 2015: 3D printing and additive manufacturing state of the industry annual worldwide progress report: Wohlers Associates; 2015.

Yu DG, Zhu LM, Branford White CJ, Yang XL. Three-dimensional printing in pharmaceutics: promises and problems. J Pharm Sci 2008;97:3666-90.

Sethia S, Squillante E. Solid dispersions: revival with greater possibilities and applications in oral drug delivery. Crit Rev Ther Drug Carrier Syst 2003;20:215-47.

Ventola CL. Medical applications for 3D printing: current and projected uses. Pharm Ther 2014;39:704-11.

Marzuka SK, Kulsum JU. 3D Printing: a new avenue in pharmaceuticals. World J Pharm Res 2016;5:1686-701.

Maulvi FA, Shah JM, Solanki BS, Patel AS, Soni TG, Shah DO. Application of 3D printing technology in the development of novel drug delivery systems. Int J Drug Dev Res 2017;9:44-9.

United States Food and Drug Administration. Additive manufacturing of medical devices public workshop–transcript; 2014. Available from: http://www.fda.gov/downloads/-MedicalDevices/NewsEvents/WorkshopsConferences/UC M425399.pdfG. [Last accessed on 20 Dec 2017]

Borukhovich E. How 3d printing will change the pharmaceutical world forever. Insider; 2016.

Bala R, Madaan R, Kaur A, Mahajan K. 3D printing: basic role in pharmacy. Eur J Biomed Pharm Sci 2017;4:242-7.

Bhusnure OG, Gholve SV, Sugave BK, Dongre RC, Gore SA, Giram PS. 3D Printing and pharmaceutical manufacturing: opportunities and challenges. Int J Bioassays 2016;5:4723-38.

Schubert C, Van Langeveld MC, Donoso LA. Innovations in 3D printing: a 3D overview from optics to organs. Br J Ophthalmol 2014;98:159–61.

Gosnear T, Brettler D. Three big risks in 3D printing pharmaceuticals are the risks of leveraging this new technology outweighing the benefits for drug makers? Ran Pharmaceutical Manufacturing; 2016.

Acosta-Velez GF, Wu BM. 3D pharming: direct printing of personalized pharmaceutical tablets. Polym Sci 2016;2:1-10.

Sundaramurthi D, Rauf S, Hauser CAE. 3D bioprinting technology for regenerative medicine applications. Int J Bioprint 2016;2:9–26.

Jassim Jaboori AH, Oyewumi MO. 3D printing technology in pharmaceutical drug delivery: prospects and challenges. J Biomol Res Ther 2015;4:1-3.

Patil PA, Dange VN, Shid SJ. 3D printing a revolutionary approach in medicinal science review. Int J Res Methodol 2016;1:1-11.

Bose S, Vahabzadeh S, Bandyopadhyay A. Bone tissue engineering using 3D printing. Mater Today 2013;16:496-504.

Zhang YS, Duchamp M, Oklu R, Ellisen LW, Langer R. Bio printing the cancer microenvironment. ACS Biomater Sci Eng 2016;2:1710-21.

Mok SW, Nizak R, Fu SC, Ho KWK, Qin L. From the printer: potential of three-dimensional printing for orthopaedic applications. J Orthopaedic Translation 2016;6:42-9.

Lee SJ, Lee D, Yoon TR, Kim HK, Jo HH. Surface modification of 3D-printed porous scaffolds via mussel-inspired polydopamine and effective immobilization of rhBMP-2 to promote osteogenic differentiation for bone tissue engineering. Acta Biomater 2016;40:182-91.

Xu Y, Wang X. Application of 3D biomimetic models in drug delivery and regenerative medicine. Curr Pharm Des 2015;21:1618-26.

Liu L, Zhou X, Xu Y, Zhang W, Liu CH. Controlled release of growth factors for regenerative medicine. Curr Pharm Des 2015;21:1627-32.

Wang X. Drug delivery design for regenerative medicine. Curr Pharm Des 2015;21:1503.

Rijal G, Li W. 3D scaffolds in breast cancer research. Biomaterials 2016;81:135-56.

King SM, Gorgen V, Presnell SC, Nguyen DG, Shepherd BR. Development of 3D bio printed human breast cancer for in vitro screening of therapeutics targeted against cancer progression. American Soceity of Biology, New Orleans, LA; 2013.

Katstra W, Palazzolo R, Rowe C, Giritlioglu B, Teung P. Oral dosage forms fabricated by three dimensional printing. J Controlled Release 2000;66:1-9.

Rowe C, Katstra W, Palazzolo R, Giritlioglu B, Teung P. Multi mechanism oral dosage forms fabricated by three dimensional printing. J Controlled Release 2000;66:11-7.

Santini JT, Cima MJ, Langer R. A controlled-release microchip. Nature 1999;397:335-8.

Cima LG, Cima MJ. Preparation of medical devices by solid free-form fabrication methods. Google Patents; 1996.

Monkhouse D, Sandeep K, Rowe C, Yoo J. A complex-aided fabrication process for rapid designing, prototyping and manufacturing. WO Patent 2000. p. 29202.

Monkhouse D, Yoo J, Sherwood JK, Cima MJ, Bornancini E. Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof; 2003.

Maraie NK, Salman ZD, Yousif NZ. Design and characterization of oroslippery buoyant tablets for ranitidine hydrochloride. Asian J Pharm Clin Res 2018;11:143-9.

Panda N, Reddy AV, Reddy GVS, Sultana A. Formulation design and in vitro evaluation of bilayer sustained release matrix tablets of doxofylline. Int J Pharm Pharm Sci 2015;7:74-83.

Salem HF, Tamam SM, Lotayef SM. Biodegradable liposomes for acyclovir-gold nanoparticles as an efficient carrierfor enhanced topical delivery. Int J Pharm Pharm Sci 2017;9:60-4.

Shah H, Patel J. Bicelle: a lipid nanostructure for transdermal delivery. J Crit Rev 2016;3:17-22.

Wang X, Mäkitie AA, Partanen J, Tuomi J, Paloheimo KS. The integrations of biomaterials and rapid prototyping techniques for intelligent manufacturing of complex organs. INTECH Open Access Publisher; 2013.

Le HP. Progress and trends in ink-jet printing technology. J Imaging Sci Technol 1998;42:49-62.

Subramanian V, Frechet JM, Chang PC, Huang DC, Lee JB, et al. Progress toward development of all-printed RFID tags: materials, processes, and devices. Proc IEEE 2005;93:1330-8.

Melchels FP, Feijen J, Grijpma DW. A review on stereolithography and its applications in biomedical engineering. Biomaterials 2010;31:6121-30.

Kolakovic R, Viitala T, Ihalainen P, Genina N, Peltonen J, Sandler N. Printing technologies in fabrication of drug delivery systems. Expert Opin Drug Delivery 2013;10:1711-23.

Preis M, Breitkreutz J, Sandler N. Perspective: concepts of printing technologies for oral film formulations. Int J Pharm 2015;494:578-84.

Genina N, Kolakovic R, Palo M, Fors D, Juvonen H. Fabrication of printed drug-delivery systems. NIP and Digital Fabrication Conference: Society for Imaging Science and Technology; 2013. p. 236-8.

Ihalainen P, Maattanen A, Sandler N. Printing technologies for biomolecule and cell-based applications. Int J Pharm 2015;494:585-92.

Latief A, Suhardi P, Badri C. Three-dimensional model printing in oral and maxillofacial reconstructive surgery: comparison of three-dimensional models and multislice computed tomography scans. Int J Appl Pharm 2017;9:74-8.

Gu BK, Choi DJ, Park SJ, Kim MS, Kang CM, Kim CH. 3-dimensional bioprinting for tissue engineering applications. Biomater Res 2016;20:1-8.

Lewis JA. Direct ink writing of 3D functional materials. Adv Funct Mater 2006;16:2193–204.

Yu DG, Yang XL, Xu HB, ZENG FD. Application of three-dimensional printing in pharmaceutics. Chinese New Drugs J 2005;14:843.

Katakam P, Dey B, Assaleh FH, Hwisa NT, Adiki SK. Top-down and bottom-Up approaches in 3D printing technologies for drug delivery challenges. Crit Rev Ther Drug Carrier Syst 2015;32:61-87.

Aprecia Pharmacuticals. FDA approves the first 3D printed drug product aprecia introduces its first product using the ZipDose® formulation platform for the treatment of epilepsy; 2015.

Buanz AB, Saunders MH, Basit AW, Gaisford S. Preparation of personalized-dose salbutamol sulphate oral films with thermal ink-jet printing. Pharm Res 2011;28:2386-92.

Melendez PA, Kane KM, Ashvar CS, Albrecht M, Smith PA. Thermal inkjet application in the preparation of oral dosage forms: dispensing of prednisolone solutions and polymorphic characterization by solid-state spectroscopic techniques. J Pharm Sci 2008;97:2619-936.

Gibson I, Rosen D, Stucker B. Additive manufacturing technologies: 3D printing, rapid prototyping, and direct digital manufacturing. Johnson Matthey Technol Rev 2015;59:193–8.

Norman J, Madurawe RD, Moore CMV, Khan MA, Khairuzzaman A. A new chapter in pharmaceutical manufacturing: 3D printed drug products. Adv Drug Delivery Rev 2017;108:39-50.

Alhnan A, Mohamed, Okwuosa, Tochukwu, Sadia, Muzna, et al. Emergence of 3D printed dosage forms: opportunities and challenges. Pharm Res 2016;33:1817­32.

Centers for Disease Control and Prevention. Epilepsy Fast Facts; 2015. Available from: http://www.cdc.gov/epilepsy/ basics/fast-facts.htm. [Last accessed 29 Jul 2015]

Sandler N, Salmela I, Fallarero A, Rosling A, Khajeheian M, Kolakovic R, et al. Towards fabrication of 3D printed medical devices to prevent biofilm formation. Int J Pharm 2014;459:62-4.

Masood SH. Application of fused deposition modelling in controlled drug delivery devices. Assembly Automation 2007;27:215-21.

Weisman JA, Nicholson JC, Tappa K, Jammalamadaka U, Wilson CG, Mills DK. Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications. Int J Nanomed 2015;10:357-70.

Water JJ, Bohr A, Boetker J, Aho J, Sandler N, Nielson HM, et al. Three Dimensional printing of drug eluting implants: preparation of an antimicrobial polylactide feedstock material. J Pharm Sci 2015;104:1099-107.

Melocchi A, Parietti F, Loreti G, Maroni A, Gazzaniga A, Zema L. 3D printing by fused deposition modeling (FDM) of a swellable/erodible capsular device for oral pulsatile release of drugs. J Drug Delivery Sci Technol 2015;30:360-7.

Goyanes A, Chang H, Sedough D, Hatton GB, Wang J, Buanz A, et al. Fabrication of controlled-release budesonide tablets via desktop (FDM) 3D printing. Int J Pharm 2015;496:414-20.

Khaled SA, Burley JC, Alexander MR, Yang J, Roberts CJ. 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles. J Controlled Release 2015;217:308-14.

Goyanes A, Buanz AB, Basit AW, Gaisford S. Fused-filament 3D printing (3DP) for fabrication of tablets. Int J Pharm 2014;476:88-92.

Goyanes A, Buanz AB, Hatton GB, Gaisford S, Basit AW. 3D printing of modified-release aminosalicylate (4-ASA and 5-ASA) tablets. Eur J Pharm Biopharm 2015;89:157-62.

Genina N, Holländer J, Jukarainen H, Mäkilä E, Salonen J et al. Ethylene vinyl acetate (EVA) as a new drug carrier for 3D printed medical drug delivery devices. Eur J Pharm Sci 2016;90:53-63.

Sadia M, Sośnicka A, Arafat B, Isreb A, Ahmed W, et al. Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient tailored immediate release tablets. Int J Pharm 2016;513:659-68.

Meléndez PA, Kane KM, Ashvar CS, Albrecht M, Smith PA. Thermal inkjet application in the preparation of oral dosage forms: Dispensing of prednisolone solutions and polymorphic characterization by solid-state spectroscopic techniques. J P Sci 2008;97:2619-636.

Buanz AB, Saunders MH, Basit AW, Gaisford S. Preparation of personalized-dose salbutamol sulphate oral films with thermal ink-jet printing. Pharm Res 2011;28:2386-92.

Gross BC, Erkal JL, Lockwood SY. Evaluation of 3D printing and its potential impact on biotechnology and the chemical sciences. Anal Chem 2014;86:3240–53.

Scoutaris N, Alexander MR, Gellert PR, Roberts CJ. Inkjet printing as a novel medicine formulation technique. J Controlled Release 2011;156:179-85.

Pardeike J, Strohmeier DM, Schrödl N, Voura C, Gruber M. Nano suspensions as advanced printing ink for accurate dosing of poorly soluble drugs in personalized medicines. Int J Pharm 2011;420:93-100.

Cramer JA, Glassman M, Rienzi V. The relationship between poor medication compliance and seizures. Epilepsy Behavior 2002;3:338-42.

Jacob J, Coyle N, West TG, Monkhouse DC, Surprenant HL, Jain NB. Rapid disperse dosage form containing levetiracetam. WO2014144512 A1; 2014.

Thomas D, Tehrani Z, Redfearn B. 3-D printed composite microfluidic pump for wearable biomedical applications. Additive Manufacturing 2016;9:30-8.

Yu DG, Shen XX, Branford WC, Zhu LM, White K, Yang XL. Novel oral fast disintegrating drug delivery devices with predefined inner structure fabricated by three dimensional printing. J Pharm Pharmacol 2009;61:323-9.

Wang JC, Chang MW, Ahmad Z, Li JS. Fabrication of patterned polymer antibiotic composite fibers via electrohydrodynamic (EHD) printing. J Drug Delivery Sci Technol 2016;35:114-23.

Wang J, Goyanes A, Gaisford S, Basit AW. Stereolithographic (SLA) 3D printing of oral modified-release dosage forms. Int J Pharm 2016;503:207-12.

Goyanes A, Wang J, Buanz A, Martinez-Pacheco R, Telford R. 3D printing of medicines: engineering novel oral devices with unique design and drug release characteristics. Mol Pharm 2015;12:4077-84.

Yi HG, Choi YJ, Kang KS, Hong JM, Pati RG. A 3D-printed local drug delivery patch for pancreatic cancer growth suppression. J Controlled Release 2016;238:231-41.

Gbureck U, Vorndran E, Müller FA, Barralet JE. Low temperature direct 3D printed bioceramics and biocomposites as drug release matrices. J Controlled Release 2007;122:173-80.

Rowe C, Katstra W, Palazzolo R, Giritlioglu B, Teung P. Multi mechanism oral dosage forms fabricated by three dimensional printing. J Controlled Release 2000;66:11-7.

Rattanakit P, Moulton SE, Santiago KS, Liawruangrath S, Wallace GG. Extrusion printed polymer structures: a facile and versatile approach to tailored drug delivery platforms. Int J Pharm 2012;422:254-63.

Goyanes A, Det-Amornrat U, Wang J, Basit AW, Gaisford S. 3D scanning and 3D printing as innovative technologies for fabricating personalized topical drug delivery systems. J Controlled Release 2016;234:41-8.

Goyanes A, Martinez PR, Buanz A, Basit AW, Gaisford S. Effect of geometry on drug release from 3D printed tablets. Int J Pharm 2015;494:657-63.

Lee BK, Yun YH, Choi JS, Choi YC, Kim JD. Fabrication of drug loaded polymer microparticles with arbitrary geometries using a piezoelectric inkjet printing system. Int J Pharm 2012;427:305-10.

Published

07-05-2018

How to Cite

Bansal, M., Sharma, V., Singh, G., & Harikumar, S. L. (2018). 3D PRINTING FOR THE FUTURE OF PHARMACEUTICALS DOSAGES FORMS. International Journal of Applied Pharmaceutics, 10(3), 1–7. https://doi.org/10.22159/ijap.2018v10i3.25024

Issue

Section

Review Article(s)

Similar Articles

<< < 31 32 33 34 35 > >> 

You may also start an advanced similarity search for this article.