• Febriyanti Wulandari Herbal Master Program, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia.
  • Joshita Djajadisastra Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia.
  • Berna Elya Department of Phytochemical and Pharmacognosy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia.




Erythema, Selaginella sp, Lagenaria sp, Flavonoids, Amino acids, Fraction of ethanol, Lotion


Objective: The aim of this study is to evaluate the physical stability of two lotion formulations containing Selaginella plana and Lagenaria siceraria
(Molina) Standl. and investigated their safety and efficacy to relieve erythema due to exposure to the sun.
Methods: We conducted a randomized controlled trial consisting of five treatment groups: Negative control, positive control, neutral control, formula
A test group (containing a 1% ethanolic fraction of S. plana and a 0.5% ethanolic fraction of L. siceraria [Molina] Standl.), and formula B test group
(containing a 0.5% ethanolic fraction of S. plana and a 1% ethanolic fraction of L. siceraria [Molina] Standl.). Each group had erythema induced by
exposure to sunlight for 30 min between 10:00 and 16:00. The severities of erythema 1, 3, and 24 h after application were assessed.
Results: Formula A was significantly better than formula B (p<0.05) at reducing the severity of erythema.
Conclusion: Formula A containing a 1% ethanol fraction of S. plana and a 0.5% ethanol fraction of L. siceraria (Molina) Standl. showed the greatest
reduction in the level of erythema (p<0.05). S. plana may reduce the prostaglandin synthesis caused by sun exposure.


Download data is not yet available.


Han A, Maibach HI. Management of acute sunburn. Am J Clin Dermatol


D’Orazio J, Jarrett S, Amaro-Ortiz AA, Scott T. UV radiation and the

skin. Int J Mol Sci 2013;14:12222-48.

Lopes DM, McMahon SB. Ultraviolet radiation on the skin: A Painful

experience? CNS Neurosci Ther 2016;22:118-26.

Diffey BL. Sources and measurement of ultraviolet radiation. Methods


Schwarz T. Mechanisms of UV-induced immunosuppression. Keio J

Med 2005;54:165-71.

Tabassum N, Hamdani M. Plants used to treat skin diseases. Pharmacogn

Rev 2014;8:52-60.

Shweta K, Swarnlata S. Formulation and evaluation of moisturizer

containing herbal extracts for the management of dry skin. Phcog Net


Puvabanditsin P, Vongtongsri R. Efficacy of Aloe vera cream in

prevention and treatment of sunburn and suntan. J Med Assoc Thai

;88 Suppl 4:S173-6.

Tadokoro T, Yamaguchi Y, Batzer J, Coelho SG, Zmudzka BZ,

Miller SA, et al. Mechanisms of skin tanning in different racial/

ethnic groups in response to ultraviolet radiation. J Invest Dermatol


Brenner M, Hearing VJ. The protective role of melanin against UV

damage in human skin. Photochem Photobiol 2008;84:539-49.

Shah BN, Seth AK. Pharmacognostic studies of the Lagenaria siceraria

(MOLINA) standley. Int J Pharm Tech Res 2010;2:121-4.

Prajapati RP, Kalaria MV, Karkare VP, Parmar SK, Sheth NR. Effect

of methanolic extract of Lagenaria siceraria (Molina) standley fruits

on marble-burying behavior in mice: Implications for obsessivecompulsive

disorder. Pharmacognosy Res 2011;3:62-6.

Mashilo J, Shimelis H, Odindo A. Phenotypic and genotypic

characterization of bottle gourd [Lagenaria siceraria (Molina) Stabdl.]

and implications for breeding: A review. Sci Horticult 2017;222:136‑44.

Pourmorad F, Hosseinimehr SJ, Shahabimajd N. Antioxidant activity,

phenol and flavonoid contents of some selected Iranian medicinal

plants. Afr J Biotechnol 2006;5:1142-5.

Reuter J, Jocher A, Stump J, Grossjohann B, Franke G, Schempp CM,

et al. Investigation of the anti-inflammatory potential of Aloe vera

gel (97.5%) in the ultraviolet erythema test. Skin Pharmacol Physiol


Sayre RM, Agin PP, LeVee GJ, Marlowe E. A comparison of in vivo

and in vitro testing of sunscreening formulas. Photochem Photobiol




How to Cite

Wulandari, F., Djajadisastra, J., & Elya, B. (2018). EFFICACY OF LOTION CONTAINING FRACTIONS OF SELAGINELLA PLANA LEAVES AND LAGENARIA SICERARIA (MOLINA) STANDL. FRUIT FOR RELIEF OF SKIN ERYTHEMA. International Journal of Applied Pharmaceutics, 10(1), 182–184. https://doi.org/10.22159/ijap.2018.v10s1.40



Original Article(s)

Most read articles by the same author(s)

1 2 3 > >>