PREPARATION AND EVALUATION OF PROPRANOLOL HCL AND CARBAMAZEPINE RELEASE PROFILES FROM POLY(Є-CAPROLACTONE) MICROPARTICLE BLENDS SYSTEM

MUHAIMIN MUHAIMIN; ANIS YOHANA CHAERUNISAA; AGHNIA HAZRINA

doi:10.22159/ijap.2023v15i5.48574

Authors

MUHAIMIN MUHAIMIN Departmentof Pharmaceutical Biology, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21, Jatinangor-45363, Indonesia. Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21, Jatinangor-45363, Indonesia https://orcid.org/0000-0002-6269-5931
ANIS YOHANA CHAERUNISAA Departmentof Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21, Jatinangor-45363, Indonesia. Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21, Jatinangor-45363, Indonesia
AGHNIA HAZRINA Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21, Jatinangor-45363, Indonesia

DOI:

https://doi.org/10.22159/ijap.2023v15i5.48574

Keywords:

Microparticle blends, Propranolol HCl, Carbamazepine, Poly(є-caprolactone), FBRM, Solvent evaporation method

Abstract

Objective: The goal of this research was to look into the physicochemical properties of poly(-caprolactone) microparticle blends that contained medicines of various solubilities (Propranolol HCl [Pro] and carbamazepine [CBZ]).

Methods: W/O/W emulsion for Pro and O/W emulsion for CBZ were used to create microparticle blends. With dispersion time intervals (DTI) of 0 and 60 min, the Pro emulsion (W/O) and CBZ oil phase (O) were dispersed in an external aqueous phase (W). Scanning electron microscopy was used to examine the morphology of microparticle blends (SEM). Focused beam reflectance measurements were utilized to monitor the particle size mean of emulsion droplets/hardened microparticles (FBRM). In phosphate buffer (pH 7.4), encapsulation efficiency (EE) and in vitro drug release were also examined.

Results: The final microparticle blends generated by solvent evaporation method were spherical and had two populations, according to the findings. The size of microparticle blends prepared with DTI 60 min and stirring duration 4 h was bigger than those prepared with DTI 0 min, according to FBRM data. In microparticle blends, encapsulation efficiency ranged from 62.05±3.74 percent to 66.38±4.16 percent for Pro and 70.56±4.62 percent to 73.85±4.11 percent for CBZ. After 28 d, drug release in phosphate buffer revealed that Pro release (33%) was shorter than CBZ release (60%) from microparticle blends with DTI 60 min. This was related to the interaction of the oil phase (CBZ) with hard particles from the primary emulsion (Pro), in which the oil phase occluded and covered surface structure of the harsh particles from the primary emulsion.

Conclusion: Novel microparticle blends comprising drugs/medicines with varying solubilities (e. g. propranolol HCl and carbamazepine) have a lot of promise as controlled-release drug delivery systems. The physical properties of microparticle blends were impacted by the type of dispersion time interval used.

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