• Silvia Surini Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia
  • Mutiah Rakhma Wisnu Wardani Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia.
  • Erny Sagita Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia.




Effervescent tablets, Nutraceutical, Grape seed


Objective: Grape is one of the most well-known fruits. People usually consume only the fruit and the skin; however, the seed is the part of the fruit
that contains important antioxidant rich polyphenol. However, grape seed and its extract have an unpleasant taste. Therefore, this study aimed to
formulate effervescent tablets containing grape seed extract (GSE) to overcome the unpleasant taste.
Methods: Effervescent tablets of GSE were formulated using three formulas, each with a different percentage of the effervescent mix. The tablets were
prepared using wet granulation method at 40% relative humidity (RH) (the ratio of the partial pressure of water vapor to the equilibrium vapor pressure of
water) and 25°C temperature. The effervescent granules and the tablets were evaluated for various characteristics in term of granules flowability, moisture
content, as well as tablets appearance, size and weight uniformity, hardness, friability, effervescence time, pH, and total phenol content. In addition, all three
formulations of the effervescent tablets and solutions were evaluated for appearance, taste, and flavor using the hedonic test that involved 30 panelists.
Results: The evaluation of the effervescent granules and tablets showed that they had good characteristics. The disintegration time of the three
formulations was within the acceptable range, between 3.67 minutes and 4.69 minutes. The pH of the effervescent solution was between 5.18 and
5.80. Based on the hedonic test, all the effervescent solutions had favorable appearance, taste, and flavor.
Conclusions: Clinical Streptococcus salivarius isolates from the dorsum of the tongue had greater potential for inhibiting Enterococcus faecalis growth
compared to the saliva isolates and control bacteria. Therefore, we can conclude that the effervescent tablets containing grape seed extract are
potential be used as a nutraceutical dosage form.


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Rajat S, Manisha S, Robin S, Sunil K. Nutraceuticals: A review. Int Res

J Pharm 2012;3:95-9.

Kruger MJ, Neil D, Myburgh KH, Sandrine L. Proanthocyanidins,

anthocyanins, and cardiovascular diseases. Food Res Int 2014;59:41‑52.

Robinson M, Lu B, Edrisinghe I, Kappagoda CT. Effect of grape seed

extract on blood pressure in subjects with pre-hypertension. J Pharm

Nutr Sci 2012;2:155-9.

Lachman L, Lieberman HA. Theory and Practice of Pharmaceutical

Industry. 3rd ed. Jakarta: Universitas Indonesia Press; 1994.

Rowe RC, Sheskey PJ, Quinn ME. Handbook of Pharmaceutical

Excipients. United States of America: Pharmaceutical Press and

American Pharmacist Association; 2009.

Ministry of Health Republic of Indonesia. Pharmacopoeia Indonesia.

th ed. Jakarta: Ministry of Health Republic of Indonesia; 2015.

Srinath KR, Chowdary CP, Palanisamy P, Vamsy KA, Aparna S, Ali SS,

et al. Formulation and evaluation of effervescent tablets of paracetamol.

Int J Pharm Res Dev 2011;3(3):76-104.

Lachman L, Lieberman HA, Kanig JL. The Theory and Practice of

Industrial Pharmacy. 3rd ed. Philadelphia, PA: Lea and Febriger; 1986.

Dewi R, Iskandarsyah I, Octarina D. Tablet effervescent of extract

belimbing wuluh (Averrhoa bilimbi L.) with various sweetener of

aspartam. Pharm Sci Res 2014;1:116-32.

Lee RE. Effervescent Tablets: Keys Facts about a Unique Effective

Dosage Form. New Hope: Amerilab Technologies; 2005.

Al-Saeedi AH, Asma H, Mohammad AH. Total phenols, total flavonoids

contents and free radical scavenging activity of seeds crude extracts

of pigeon pea traditionally used in Oman for the treatment of several

chronic diseases. Asian Pac J Trop Dis 2015;5(4):316-21.

Liangli Y. Antioxidant properties and phenolic components of grape

seeds. Glob Sci Books 2009;3:60-8.

Xia EQ, Deng GF, Guo YJ, Li HB. Biological activities of polyphenols

from grapes. Int J Mol Sci 2010;11(2):622-46.



How to Cite

Surini, S., Wardani, M. R. W., & Sagita, E. (2017). EVALUATING OF EFFERVESCENT TABLETS CONTAINING GRAPE SEED (VITIS VINIFERA L.) EXTRACT AS A NUTRACEUTICAL. International Journal of Applied Pharmaceutics, 9, 150–153. https://doi.org/10.22159/ijap.2017.v9s1.76_83



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