DETERMINATION OF THE STABILITY OF CATECHIN FROM GAMBIR (UNCARIA GAMBIR (HUNTER) ROXB) THROUGH SOLUBILIZATION MECHANISM

SEFRIANITA KAMAL; FEBRIYENTI; ERIZAL ZAINI; DACHRIYANUS HAMIDI

doi:10.22159/ijap.2022.v14s1.01

Authors

SEFRIANITA KAMAL Faculty of Pharmacy, Andalas University, Limau Manis, Pauh, Padang, West Sumatera, 25163, Pharmacy Study Program, Dharma Andalas University, Sawahan 103 A, Simpang Haru Padang, West Sumatera, 25127
FEBRIYENTI Faculty of Pharmacy, Andalas University, Limau Manis, Pauh, Padang, West Sumatera, 25163
ERIZAL ZAINI Faculty of Pharmacy, Andalas University, Limau Manis, Pauh, Padang, West Sumatera, 25163
DACHRIYANUS HAMIDI Faculty of Pharmacy, Andalas University, Limau Manis, Pauh, Padang, West Sumatera, 25163

DOI:

https://doi.org/10.22159/ijap.2022.v14s1.01

Keywords:

Solubility, Catechin, Solubilization, Stability

Abstract

Objective: This study aims to obtain the solubility of catechins in water through the solubilization mechanism and determine their stability.

Methods: The research was conducted using the method of making spontaneous solubilization.

Results: Thermodynamically stable 0.5% catechin W/O solubilization formulation can be formulated using the oil phase, namely Tween 80 (15% and 10%) as a surfactant, 15% propylene glycol and 10% glycerin and is quite stable against shaking (centrifugation) and testing. freeze-thaw or cycling test.

Conclusion: Good solubility of catechins in water by solubilization mechanism. Based on the characterization and stability testing of the formed catechin solubilization system, the solubilization system of catechins was obtained which was more stable.

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